Results 31 to 40 of about 305,020 (386)
Combined Transcriptomics and Metabolomics Analyses in Grass Carp Under Anesthetic Stress
Frontiers in Cellular and Infection Microbiology, 2022 Ctenopharyngodon Idella, as a common freshwater bony fish, is more susceptible to various diseases than other carp species, so it has been proposed as a test organism for toxicological analysis In this study, C. idella were anesthetized with MS-222 and 2-
Tianwei Wang +14 more
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Effect of two-week continuous epidural administration of 2% lidocaine on mechanical allodynia induced by spinal nerve ligation in rats [PDF]
Anesthesia and Pain Medicine, 2020 Background Lidocaine is an effective against certain types of neuropathic pain. This study aimed to investigate whether timing of initiating continuous epidural infusion of lidocaine affected the glial activation and development of neuropathic pain ...
Yuseon Cheong +3 more
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Adjuvants to local anesthetics: Current understanding and future trends
World Journal of Clinical Cases, 2017 Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by its duration of action and the dose dependent adverse effects on the cardiac and central nervous system.
A. Swain +3 more
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Are Local Anesthetics and General Anesthetics Different? [PDF]
Biophysical Journal, 2014 It is widely believed that general and local anesthetics act by different mechanisms. While there is general agreement that the mode of action of general anesthetics is poorly understood, local anesthetics are believed to block voltage-gated sodium channels and thereby affect action potentials in nerves.
Sasse-Middelhoff, Henrike +2 more
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Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
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A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal Brain
Brain Sciences, 2014 The use of volatile anesthetics, a group of general anesthetics, is an exceedingly common practice. These anesthetics may have neuroprotective effects. Over the last decade, anesthetic induced neurotoxicity in pediatric populations has gained a certain ...
Sunny Chiao, Zhiyi Zuo
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Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]
, 2014 BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
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Effects of local anesthetics on breast cancer cell viability and migration
BMC Cancer, 2018 Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery.
Ru Li +5 more
semanticscholar +1 more source
Sympathomimetic anesthetics [PDF]
Canadian Anaesthetists’ Society Journal, 1973 The characteristic anaesthetic and other pharmacological properties of phencyclidine, ketamine, dexoxadrol and etoxadrol and the structure-activity relationship of these compounds have been described. Their possible mode of action is discussed in reference to the central depressant actions of the sympathomimetic amines.
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Frontiers in Surgery, 2023 BackgroundThoraco-abdominal surgery cuts through muscle, disrupting the normal structure and function of the respiratory muscles, resulting in lower lung volumes and a higher risk of developing post-operative pulmonary complications (PPC). PPC remains an
Biruk Adie Admass +3 more
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