Chromosomal Roadblocks in Male Fertility: Mechanisms, Risk Factors and Syndromes. [PDF]
Mitrakas AG +6 more
europepmc +1 more source
Molecular profile of atypical Leydig cell tumours
Copy number variations by themselves are not sufficient to discriminate between benign and potential malignant Leydig cell tumours (LCTs). Genomic instability was only detected in malignant and atypical cases, and not in any benign tumours. Currently, the presence of metastasis remains the only malignant criterion for LCTs.
Muhammad F.K. Choudhry +6 more
wiley +1 more source
Single-cell aneuploidy and chromosomal arm imbalances define subclones with divergent transcriptomic phenotypes. [PDF]
Bai X +5 more
europepmc +1 more source
Analysis of chromosomes 9 and 11 aneuploidy frequency in pleural effusions of patients with and without malignancy: By interphase FISH technique [PDF]
Tülin Çora +3 more
openalex +1 more source
Investigation of the Telomere Length in PERI‐Implant Oral Mucosa Cells
ABSTRACT Background The biological effects of dental implants on peri‐implant tissues have been widely investigated. Recent reports of oral squamous cell carcinoma (OSCC) cases adjacent to dental implants have raised concerns regarding the potential impact of implant materials on cellular aging and oncogenic transformation.
Fernando Costa Giffoni +13 more
wiley +1 more source
Detection of Chromosomal Aneuploidy Using Exome Sequencing. [PDF]
Al-Hamed MH +9 more
europepmc +1 more source
Clinical Features Associated With Malignant Transformation of Low‐Grade Dysplasia
ABSTRACT Background Inferring risk for malignant transformation (MT) in patients with lesions diagnosed as mild or moderate oral epithelial dysplasia (low‐grade OED) remains challenging. We developed two models assessing the risk of progression to high‐grade OED (severe dysplasia or carcinoma in situ) or OSCC in patients with low‐grade OED lesions ...
Denise M. Laronde +6 more
wiley +1 more source
Approximate Bayesian computation supports a high incidence of chromosomal mosaicism in blastocyst-stage human embryos. [PDF]
Yang Q, Carioscia SA, Isada M, McCoy RC.
europepmc +1 more source
The Origin of Abnormalities in Recurrent Aneuploidy/Polyploidy [PDF]
Wendy P. Robinson +2 more
openalex +1 more source
ABSTRACT Background Oral leukoplakia (OL) is a potentially malignant disorder of the oral mucosa. Accurate prediction of malignant transformation (MT) remains a clinical challenge. This study aimed to develop and evaluate a machine learning model that integrates histopathological, demographic, and DNA content features to predict MT risk in OL.
Guilherme Iani Pontes +7 more
wiley +1 more source

