Results 201 to 210 of about 50,865 (308)

P-168. Analysis of aneuploidy in unfertilized ICSI oocytes with two rounds of triple FISH [PDF]

open access: bronze, 1997
Elena Martini   +4 more
openalex   +1 more source

USP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53

open access: yesCell Proliferation, EarlyView.
Our findings demonstrated that USP33 deubiquitinates p53 and regulates its stability, and moreover, DNA damage can stabilise p53 through enhancing its association with USP33, leading to strong DNA damage response (DDR). However, USP33 deficiency results in defective DDR, facilitating DEN‐induced hepatocarcinogenesis in hepatocyte‐specific USP33 KO mice.
Yuqi Zhu   +8 more
wiley   +1 more source

AR alterations inform circulating tumor DNA detection in metastatic castration resistant prostate cancer patients. [PDF]

open access: yesNat Commun
Knutson TP   +15 more
europepmc   +1 more source

Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells

open access: yesCell Proliferation, EarlyView.
hESCsdel18q exhibit delayed and impaired anterior neuroectoderm induction, leading to deficient RPE specification. hESCsdel18q lines showed dysregulation of TGFβ signalling, and endogenous overactivation of activin/nodal/TGFβ in hESCsdel18q leads to improper anterior/posterior neuroectodermal fate commitments.
Yingnan Lei   +9 more
wiley   +1 more source

Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging

open access: yesCell Proliferation, EarlyView.
Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi   +6 more
wiley   +1 more source

APCAD Part 2: A Novel Method for Detection of Meiotic Aneuploidy in Preimplantation Embryos. [PDF]

open access: yesGenes (Basel)
Verdyck P   +5 more
europepmc   +1 more source

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