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The Origin of Aneuploidy in Humans
1985Aneuploidy is the most common class of chromosome abnormality in humans and is considered by some to be the most important genetic hazard facing man (2). No less than 0.3% of all newborns are aneuploid (12), most with significant physical, intellectual, and behavioral abnormalities. Furthermore, these individuals are the least affected of all aneuploid
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2012
The low reproductive potential of the human species is mainly caused by aneuploidies affecting embryo o fetal development. Although some of these aneuploidies may be paternally inherited or generated mitotically during preimplantation development, the vast majority of aneuploid karyotypes are generated at fertilization as an effect of meiotic errors ...
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The low reproductive potential of the human species is mainly caused by aneuploidies affecting embryo o fetal development. Although some of these aneuploidies may be paternally inherited or generated mitotically during preimplantation development, the vast majority of aneuploid karyotypes are generated at fertilization as an effect of meiotic errors ...
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Effects of aneuploidy on cell behaviour and function
Nature Reviews Molecular Cell Biology, 2022Jin Zhu
exaly
Aneuploidy in mammalian oocytes and the impact of maternal ageing
Nature Reviews Molecular Cell Biology, 2022Chloe Charalambous +2 more
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Short- and long-term effects of chromosome mis-segregation and aneuploidy
Nature Reviews Molecular Cell Biology, 2015Stefano Santaguida +2 more
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