Results 71 to 80 of about 97,243 (292)

Adaptation to high ethanol reveals complex evolutionary pathways [PDF]

, 2015
Tolerance to high levels of ethanol is an ecologically and industrially relevant phenotype of microbes, but the molecular mechanisms underlying this complex trait remain largely unknown.
Arslan, Ahmed, Das, Anupam, De Maeyer, Dries, DeLuna, Alexander, Espinosa-Cantú, Adriana, Jelier, Rob, Kominek, Jacek, Marchal, Kathleen, Meert, Wim, van der Zande, Elisa, Van Noort, Vera, Van Pee, Michiel, Verstrepen, Kevin J, Voordeckers, Karin, Yang, Yudi, Zhu, Bp   +15 more
core   +4 more sources

Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity

Animal Models and Experimental Medicine, EarlyView.
Brefeldin A (BFA) significantly inhibits oocyte release and induces apoptosis in ovarian granulosa cells by disrupting follicular development. It downregulates proliferation‐associated genes, reduces SIRT1/SIRT6 proteins, and upregulates cell cycle inhibitors P21 and P16. Additionally, BFA impairs estrogen synthesis and affects ovarian function through
Yao Jiang, Meng Lv, Haidan Fan, Yonghua Shi, Tao Wang, Penghao Wang, Xiaolong Yuan, Fei Gao, Bin Ma   +8 more
wiley   +1 more source

Separase prevents genomic instability by controlling replication fork speed [PDF]

, 2016
Proper chromosome segregation is crucial for preserving genomic integrity, and errors in this process cause chromosome mis-segregation, which may contribute to cancer development.
Cucco, Francesco, Palumbo, Elisa, Camerini, Serena, D'Alessio, Barbara, Quarantotti, Valentina, Casella, Maria Luisa, Rizzo, Ilaria Maria, Cukrov, Dubravka, Delia, Domenico, Russo, Antonella, Crescenzi, Marco, Musio, Antonio   +11 more
core   +6 more sources

Understanding aneuploidy in cancer through the lens of system inheritance, fuzzy inheritance and emergence of new genome systems

Molecular Cytogenetics, 2018
Background In the past 15 years, impressive progress has been made to understand the molecular mechanism behind aneuploidy, largely due to the effort of using various -omics approaches to study model systems (e.g.
Christine J. Ye, Sarah Regan, Guo Liu, Sarah Alemara, Henry H. Heng   +4 more
doaj   +1 more source

Prognostic value of lupus anticoagulant and anti‐β2 glycoprotein I antibody in adverse pregnancy outcomes.

Arthritis &Rheumatology, Accepted Article.
Objective International criteria for antiphospholipid syndrome (APS) include lupus anticoagulant (LA), anticardiolipin (aCL) immunoglobulin (Ig) G and IgM, and anti‐β2‐glycoprotein I (β2GPI) IgG and IgM. However, evidence supporting their prognostic value or treatment efficacy in improving live birth rates is limited.
Megumi Nonobe, Takahiro Otani, Hiroyuki Yoshihara, Shinobu Goto, Tamao Kitaori, Naomi Nishikawa, Yuichiro Fujieda, Tatsuya Atsumi, Mayumi Sugiura‐Ogasawara   +8 more
wiley   +1 more source

Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. [PDF]

PLoS ONE, 2011
A change in chromosome number, known as aneuploidy, is a common characteristic of cancer. Aneuploidy disrupts gene expression in human cancer cells and immortalized human epithelial cells, but not in normal human cells.
Hisakatsu Nawata, Genro Kashino, Keizo Tano, Kazuhiro Daino, Yoshiya Shimada, Hiroyuki Kugoh, Mitsuo Oshimura, Masami Watanabe   +7 more
doaj   +1 more source

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Clinical and molecular correlates of tumor aneuploidy in metastatic non-small cell lung cancer

Scientific Reports
Recent studies have linked elevated tumor aneuploidy to anti-tumor immune suppression and adverse survival following immunotherapy. Herein, we provide supportive evidence for tumor aneuploidy as a biomarker of response to immunotherapy in patients with ...
Liam F. Spurr, Sean P. Pitroda
doaj   +1 more source

Preimplantation genetic testing for aneuploidy in uterus transplant patients

Therapeutic Advances in Reproductive Health, 2021
Uterus transplantation is an emerging treatment for uterine factor infertility. In vitro fertilization with cryopreservation of embryos prior is required before a patient can be listed for transplant.
Rhea Chattopadhyay, Elliott Richards, Valerie Libby, Rebecca Flyckt   +3 more
doaj   +1 more source

Short- and long-term effects of chromosome mis-segregation and aneuploidy [PDF]

, 2015
Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a ...
Amon, Angelika B, Santaguida, Stefano
core   +1 more source