Results 81 to 90 of about 63,250 (285)

Clinical practice. Prenatal screening for aneuploidy.

, 2009
http://dx.doi.org/10.1056 ...
Driscoll, Deborah A., Gross, Susan
core   +1 more source

Image1_Systematic Elucidation of the Aneuploidy Landscape and Identification of Aneuploidy Driver Genes in Prostate Cancer.TIF

, 2022
Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa
Yun Peng (464975), Yuxuan Song (725984), Haitao Wang (165102)   +2 more
core   +1 more source

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source

Embryo aneuploidy and ivf outcomes in patients with different spermatozoa aneuploidy rates

Гинекология, 2013
Our goal was to study the 13, 18, 21, X, Y chromosomes aneuploidy rate in the embryos of the couples with different spermatozoa aneuploidy rate.In prospective cohort study 56 infertile couples were divided into 3 groups by the spermatozoa aneuploidy rate
S A Sokur, N V Dolgushina, Zh I Glinkina, A G Gorshkova, E A Kalinina   +4 more
doaj  

The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1α

Cell Reports, 2018
Summary: Deviating from the normal karyotype dramatically changes gene dosage, in turn decreasing the robustness of biological networks. Consequently, aneuploidy is poorly tolerated by normal somatic cells and acts as a barrier to transformation ...
Susana Simões-Sousa, Samantha Littler, Sarah L. Thompson, Paul Minshall, Helen Whalley, Bjorn Bakker, Klaudyna Belkot, Daniela Moralli, Daniel Bronder, Anthony Tighe, Diana C.J. Spierings, Nourdine Bah, Joshua Graham, Louisa Nelson, Catherine M. Green, Floris Foijer, Paul A. Townsend, Stephen S. Taylor   +17 more
doaj   +1 more source

Longitudinal genome-wide aneuploidy measurements in circulating cell-free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer. [PDF]

Mol Oncol
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Salhi Y, Makrodimitris S, van Wilpe S, Te Paske I, de Weerd V, Beaufort CM, Westgeest HM, Voortman J, Aarts MJB, Rijnders M, van der Veldt AAM, de Wit R, Mehra N, Wilting SM, Robbrecht DGJ.   +14 more
europepmc   +2 more sources

High incidence of Y‐chromosome mosaicism in male and female individuals with mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy

Epilepsia, EarlyView.
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini, Till Hartlieb, Ahmed Gaballa, Katja Kobow, Mitali Katoch, Paraskevi Chasani, Georgia Vasileiou, Wiebke Hofer, Lea M. Reisch, Manfred Kudernatsch, Christian G. Bien, Roland Coras, Ingmar Blümcke, Lucas Hoffmann   +13 more
wiley   +1 more source

Impact of donor mare and stallion identity on the likelihood of pregnancy after transfer of in vitro produced embryos

Equine Veterinary Journal, EarlyView.
Abstract Background The success of in vitro embryo production (IVEP) is influenced by donor mare and stallion. Objectives To determine whether donor mare and stallion influence the pregnancy rate after transfer of in vitro produced (IVP) blastocysts and to identify factors influencing the likelihood of obtaining one or more pregnancies from a single ...
M. Papas, T. A. E. Stout, J. C. M. Vernooij, B. Leemans, L. Arnold, M. M. Beitsma, L. I. Wijnands, M. de Ruijter‐Villani, S. Colleoni, G. Lazzari, C. Galli, A. Claes   +11 more
wiley   +1 more source

First‐trimester maternal abdominal subcutaneous and perirenal fat thickness and early identification of gestational diabetes: A prospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate whether first‐trimester abdominal subcutaneous fat thickness (ASFT) and renal fat thickness (RFT) provide incremental value for early identification of gestational diabetes mellitus (GDM) and their association with obstetric complications.
Giulia Palla, Maria M. Montt‐Guevara, Tiziana Fidecicchi, Giulia Cappellini, Stella Zandri, Chiara Ietto, Deborah Garaffa, Giulia Posar, Elena Pisacreta, Amerigo Ferrari, Marta Caretto, Francesca Monacci, Tommaso Simoncini   +12 more
wiley   +1 more source

Aneuploidy in stem cells

World Journal of Stem Cells, 2016
Stem cells hold enormous promise for regenerative medicine as well as for engineering of model systems to study diseases and develop new drugs. The discovery of protocols that allow for generating induced pluripotent stem cells (IPSCs) from somatic cells has brought this promise steps closer to reality.
Jorge, Garcia-Martinez, Bjorn, Bakker, Klaske M, Schukken, Judith E, Simon, Floris, Foijer   +4 more
openaire   +2 more sources