Results 1 to 10 of about 93,154 (303)

Characterization of Chromosomal Instability in Glioblastoma [PDF]

Frontiers in Genetics, 2022
Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system (CNS). The poor prognosis of GBM due to resistance to therapy has been associated with high chromosomal instability (CIN).
Elisa Balzano, Elisa Balzano, Elena Di Tommaso, Elena Di Tommaso, Antonio Antoccia, Franca Pelliccia, Simona Giunta   +6 more
doaj   +3 more sources

Chromosomal instability, aneuploidy, and cancer [PDF]

Frontiers in Oncology, 2014
The link between aneuploidy and cancer has been recognized overa century ago (1). Abnormalities in chromosome copy numbersarise from persistent errors in chromosome segregation dur-ing cell division, a process known as chromosomal instability(CIN) (2).
Samuel F Bakhoum, Charles eSwanton
doaj   +3 more sources

Pervasive chromosomal instability drives the karyotypic evolution of hypodiploid tumours [PDF]

Genome Medicine
Background Tumours frequently exhibit extreme levels of aneuploidy. While increases in ploidy are well-characterised, the opposite phenomenon—extensive chromosome loss leading to hypodiploidy—remains underexplored.
Elle Loughran, Aoife McLysaght, Máire Ní Leathlobhair   +2 more
doaj   +3 more sources

Chromosomal Instability and Periodontal Disease in Idiopathic Infertility: Evidence of a Possible Association [PDF]

Biology
Background: Chromosomal instability (CIN) may underlie a subset of idiopathic infertility, and chronic periodontitis could contribute to genomic fragility.
Cristina-Crenguţa Albu, Ştefan-Dimitrie Albu, Claudia Florina Bogdan-Andreescu, Cristian-Viorel Poalelungi, Constantin Marian Damian, Alexandru Burcea, Andreea-Mariana Bănățeanu, Emin Cadar, Dan Alexandru Slăvescu, Anca Daniela Brăila   +9 more
doaj   +2 more sources

CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability [PDF]

PeerJ, 2023
Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological ...
Vishal H. Oza, Jennifer L. Fisher, Roshan Darji, Brittany N. Lasseigne   +3 more
doaj   +2 more sources

Profile of Chromosomal Alterations, Chromosomal Instability and Clonal Heterogeneity in Colombian Farmers Exposed to Pesticides

Frontiers in Genetics, 2022
Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
María Paula Meléndez-Flórez, Duvan Sebastián Valbuena, Sebastián Cepeda, Nelson Rangel, Maribel Forero-Castro, María Martínez-Agüero, Milena Rondón-Lagos   +6 more
doaj   +1 more source

Effect of chromosomal instability on the mutation-selection balance in unicellular populations. [PDF]

PLoS ONE, 2012
This paper develops a mathematical model describing the evolutionary dynamics of a unicellular, asexually replicating population exhibiting chromosomal instability.
Eran Itan, Emmanuel Tannenbaum
doaj   +1 more source

Chromosome instability syndromes [PDF]

Nature Reviews Disease Primers, 2019
Fanconi anaemia (FA), ataxia telangiectasia (A-T), Nijmegen breakage syndrome (NBS) and Bloom syndrome (BS) are clinically distinct, chromosome instability (or breakage) disorders. Each disorder has its own pattern of chromosomal damage, with cells from these patients being hypersensitive to particular genotoxic drugs, indicating that the underlying ...
Taylor, A. Malcolm R., Rothblum-Oviatt, Cynthia, Ellis, Nathan A., Hickson, Ian D., Meyer, Stefan, Crawford, Thomas O., Smogorzewska, Agata, Pietrucha, Barbara, Weemaes, Corry, Stewart, Grant S.   +9 more
openaire   +10 more sources

Genomic signatures of past and present chromosomal instability in Barrett’s esophagus and early esophageal adenocarcinoma

Nature Communications, 2023
The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood.
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang   +17 more
doaj   +1 more source

Chromosomal Instability in Meningiomas [PDF]

Journal of Neuropathology & Experimental Neurology, 2005
Approximately 60% of sporadic meningiomas are caused by inactivation of the NF2 tumor suppressor gene on chromosome 22. No causative gene is known for the remaining 40%. Cytogenetic analysis shows that meningiomas caused by inactivation of the NF2 gene can be divided into tumors that show monosomy 22 as the sole abnormality and tumors with a more ...
Tilborg, Angela, Al Allak, B, Velthuizen, Sandra, de Vries, A (Annie), Kros, J.M., Avezaat, CJJ, de Klein, Annelies, Beverloo, Berna, Zwarthoff, Ellen   +8 more
openaire   +3 more sources