Perceived Stress Levels, Chemotherapy, Radiation Treatment and Tumor Characteristics Are Associated with a Persistent Increased Frequency of Somatic Chromosomal Instability in Women Diagnosed with Breast Cancer: A One Year Longitudinal Study. [PDF]
PLoS ONE, 2015 While advances in therapeutic approaches have resulted in improved survival rates for women diagnosed with breast cancer, subsets of these survivors develop persistent psychoneurological symptoms (fatigue, depression/anxiety, cognitive dysfunction) that ...
Noran Aboalela +6 more
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Chromosomal instability, aneuploidy, and cancer [PDF]
Frontiers in Oncology, 2014 The link between aneuploidy and cancer has been recognized overa century ago (1). Abnormalities in chromosome copy numbersarise from persistent errors in chromosome segregation dur-ing cell division, a process known as chromosomal instability(CIN) (2).
Samuel F Bakhoum, Charles eSwanton
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Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. [PDF]
PLoS ONE, 2012 Chromosomal instability is the major form of genomic instability in cancer cells. Amongst various forms of chromosomal instability, pericentromeric or centromeric instability remains particularly poorly understood.
Wen Deng +3 more
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Chromosomal Instability and Periodontal Disease in Idiopathic Infertility: Evidence of a Possible Association. [PDF]
Biology (Basel)Background: Chromosomal instability (CIN) may underlie a subset of idiopathic infertility, and chronic periodontitis could contribute to genomic fragility.
Albu CC +9 more
europepmc +2 more sources
Breast tumor copy number aberration phenotypes and genomic instability [PDF]
BMC Cancer, 2006 Background Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g.
Ljung Britt +18 more
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CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability [PDF]
PeerJ, 2023 Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological ...
Vishal H. Oza +3 more
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Chromosome instability syndromes [PDF]
Nature Reviews Disease Primers, 2019 Fanconi anaemia (FA), ataxia telangiectasia (A-T), Nijmegen breakage syndrome (NBS) and Bloom syndrome (BS) are clinically distinct, chromosome instability (or breakage) disorders. Each disorder has its own pattern of chromosomal damage, with cells from these patients being hypersensitive to particular genotoxic drugs, indicating that the underlying ...
Taylor, A. Malcolm R. +9 more
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Frontiers in Genetics, 2022 Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
María Paula Meléndez-Flórez +6 more
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Effect of chromosomal instability on the mutation-selection balance in unicellular populations. [PDF]
PLoS ONE, 2012 This paper develops a mathematical model describing the evolutionary dynamics of a unicellular, asexually replicating population exhibiting chromosomal instability.
Eran Itan, Emmanuel Tannenbaum
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Nature Communications, 2023 The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood.
Chunyang Bao +17 more
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