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Characterization of Chromosomal Instability in Glioblastoma [PDF]
Frontiers in Genetics, 2022 Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system (CNS). The poor prognosis of GBM due to resistance to therapy has been associated with high chromosomal instability (CIN).
Elisa Balzano +6 more
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CINmetrics: an R package for analyzing copy number aberrations as a measure of chromosomal instability [PDF]
PeerJ, 2023 Genomic instability is an important hallmark of cancer and more recently has been identified in others like neurodegenrative diseases. Chromosomal instability, as a measure of genomic instability, has been used to characterize clinical and biological ...
Vishal H. Oza +3 more
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Frontiers in Genetics, 2022 Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
María Paula Meléndez-Flórez +6 more
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Effect of chromosomal instability on the mutation-selection balance in unicellular populations. [PDF]
PLoS ONE, 2012 This paper develops a mathematical model describing the evolutionary dynamics of a unicellular, asexually replicating population exhibiting chromosomal instability.
Eran Itan, Emmanuel Tannenbaum
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Nature Communications, 2023 The progression of precancerous lesions to malignancy is often accompanied by increasing complexity of chromosomal alterations but how these alterations arise is poorly understood.
Chunyang Bao +17 more
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Short-term molecular consequences of chromosome mis-segregation for genome stability
Nature Communications, 2023 Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Lorenza Garribba +21 more
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Cancer Reports, 2023 Background Cancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive.
Sasha Taluri +4 more
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Breast, 2020 Background: Genome-wide chromosomal instability, instead of specific somatic mutations or copy-number alterations in selected genes, is a significant property of cancer and may suggest a new strategy for treatment.
Hongnan Mo +9 more
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Perceived Stress Levels, Chemotherapy, Radiation Treatment and Tumor Characteristics Are Associated with a Persistent Increased Frequency of Somatic Chromosomal Instability in Women Diagnosed with Breast Cancer: A One Year Longitudinal Study. [PDF]
PLoS ONE, 2015 While advances in therapeutic approaches have resulted in improved survival rates for women diagnosed with breast cancer, subsets of these survivors develop persistent psychoneurological symptoms (fatigue, depression/anxiety, cognitive dysfunction) that ...
Noran Aboalela +6 more
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Chromosomal instability in adult-type diffuse gliomas
Acta Neuropathologica Communications, 2022 Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying mechanism of tumorigenesis and malignant progression, and has been documented in a wide variety of cancers, including colorectal carcinoma with mutations in genes such
Timothy E. Richardson +8 more
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