Results 21 to 30 of about 85,648 (260)
Molecular Cancer, 2003 Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability.
Cin Paola +3 more
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High-grade serous ovarian carcinoma organoids as models of chromosomal instability
eLife, 2023 High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity.
Maria Vias +13 more
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Scientific Reports, 2021 Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye +9 more
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Neoplasia: An International Journal for Oncology Research, 2008 Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell population.
Anna V. Roschke +5 more
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Epigenetic Instability and Chromosomal Instability in Hepatocellular Carcinoma [PDF]
The American Journal of Pathology, 2006 The aim of this study was to clarify the association between the epigenetic instability phenotype and the chromosomal instability phenotype in primary hepatocellular carcinoma (HCC). Sixty primary HCC tumors were examined. Methylation status for nine CpG islands (the p16, COX2, GSTP1, RASSF1A, E-cadherin, and APC gene promoters, and the MINT 1, 25, and
Hiroto, Katoh +6 more
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In silico pathway analysis based on chromosomal instability in breast cancer patients
BMC Medical Genomics, 2020 Background Complex genomic changes that arise in tumors are a consequence of chromosomal instability. In tumor cells genomic aberrations disrupt core signaling pathways involving various genes, thus delineating of signaling pathways can help understand ...
Akeen Kour +6 more
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Studying chromosome instability in the mouse [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2008 Aneuploidy has long been recognized as one of the hallmarks of cancer. It nonetheless remains uncertain whether aneuploidy occurring early in the development of a cancer is a primary cause of oncogenic transformation, or whether it is an epiphenomenon that arises from a general breakdown in cell cycle control late in tumorigenesis.
Floris, Foijer +2 more
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EMBO Molecular Medicine, 2020 Oncogene‐addicted tumors present a valuable target for therapeutic intervention and an opportunity to achieve a wide therapeutic window. Nonetheless, resistance to targeted therapies is frequently observed and it arises through multiple mechanisms ...
Daniel Bronder, Samuel F Bakhoum
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Causes of Chromosomal Instability
, 2015 The majority of human cancer cells are highly aneuploid harboring chromosome numbers deviating from the modal number of 46. In cancer, aneuploidy is a consequence of an increased rate of whole chromosome missegregation during mitosis, a process known as chromosomal instability (CIN).
Bastians, Holger +2 more
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Chromosomal Instability in Gastric Cancer Biology
Neoplasia: An International Journal for Oncology Research, 2017 Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the total cancer incidence. The prognosis of GC is dismal in Western countries due to late diagnosis: approximately 70% of the patients die within 5 years following ...
Saffiyeh Saboor Maleki +1 more
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