Multi-layered cancer chromosomal instability phenotype
Frontiers in Oncology, 2013 Whole chromosomal instability (W-CIN) – unequal chromosome distribution during cell division - is a characteristic feature of a majority of cancer cells distinguishing them from their normal counterparts.
Anna V Roschke, Ester eRozenblum
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A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables. [PDF]
, 2011 Breast cancer in younger patients often presents with adverse histopathological features, including increased frequency of estrogen receptor negative and lymph node positive disease status.
Endesfelder, David +6 more
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Cytogenetic studies of Myodes glareolus from the natural populations of the Chornobyl Exclusion Zone in the remote post-accident period [PDF]
Ядерна фізика та енергетика, 2022 The results of cytogenetic studies of bank voles (Myodes glareolus) carried out during 2009 - 2016 in the areas of the Chornobyl Exclusion Zone with different levels of radionuclide contamination are presented.
N. M. Riabchenko +2 more
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Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly [PDF]
, 2017 Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors.
Alessandra Maria Adelaide, Chiotto +21 more
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Telomere-Dependent Chromosomal Instability [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2005 Telomeres are specialized DNA-protein structures at the ends of the linear chromosomes. In mammalian cells, they are composed of multifold hexameric TTAGGG repeats and a number of associated proteins. The double-stranded telomeric DNA ends in a 3' single stranded overhang of 150 to 300 base pair (bp) which is believed to be required for a higher order ...
Boukamp, Petra +2 more
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The extent of error-prone replication-restart by homologous recombination is controlled by Exo1 and checkpoint proteins [PDF]
, 2014 Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components ...
Ahn +80 more
core +7 more sources
Molecular Cancer, 2003 Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability.
Cin Paola +3 more
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High-grade serous ovarian carcinoma organoids as models of chromosomal instability
eLife, 2023 High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity.
Maria Vias +13 more
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DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]
, 2014 Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Abdel-Rahman +44 more
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Mechanisms of Chromosomal Instability [PDF]
Current Biology, 2010 Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by ...
Thompson, Sarah L. +2 more
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