Mechanisms of chromosomal instability and carcinogenesis [PDF]
, 2013 Most carcinomas present some form of genetic instability, either as a shortening or lengthening of PCR markers termed microsatellite instability or as a change in the relative intensity of paternal and maternal alleles termed chromosomal instability ...
Van Wely, Karel H. M.
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Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells [PDF]
, 2010 Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this ...
Valeri, Antonio +71 more
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Chromosomal instability in adult-type diffuse gliomas
Acta Neuropathologica Communications, 2022 Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying mechanism of tumorigenesis and malignant progression, and has been documented in a wide variety of cancers, including colorectal carcinoma with mutations in genes such
Timothy E. Richardson +8 more
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DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy [PDF]
, 2014 Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN).
Ilyas, Mohammad +13 more
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Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. [PDF]
PLoS ONE, 2012 Chromosomal instability is the major form of genomic instability in cancer cells. Amongst various forms of chromosomal instability, pericentromeric or centromeric instability remains particularly poorly understood.
Wen Deng +3 more
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Multi-layered cancer chromosomal instability phenotype
Frontiers in Oncology, 2013 Whole chromosomal instability (W-CIN) – unequal chromosome distribution during cell division - is a characteristic feature of a majority of cancer cells distinguishing them from their normal counterparts.
Anna V Roschke, Ester eRozenblum
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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]
, 2007 Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Newton, Ian P. +32 more
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Cytogenetic studies of Myodes glareolus from the natural populations of the Chornobyl Exclusion Zone in the remote post-accident period [PDF]
Ядерна фізика та енергетика, 2022 The results of cytogenetic studies of bank voles (Myodes glareolus) carried out during 2009 - 2016 in the areas of the Chornobyl Exclusion Zone with different levels of radionuclide contamination are presented.
N. M. Riabchenko +2 more
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Molecular Cancer, 2003 Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instability.
Cin Paola +3 more
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High-grade serous ovarian carcinoma organoids as models of chromosomal instability
eLife, 2023 High-grade serous ovarian carcinoma (HGSOC) is the most genomically complex cancer, characterized by ubiquitous TP53 mutation, profound chromosomal instability, and heterogeneity.
Maria Vias +13 more
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