Results 11 to 20 of about 85,648 (260)

Pervasive chromosomal instability drives the karyotypic evolution of hypodiploid tumours [PDF]

Genome Medicine
Background Tumours frequently exhibit extreme levels of aneuploidy. While increases in ploidy are well-characterised, the opposite phenomenon—extensive chromosome loss leading to hypodiploidy—remains underexplored.
Elle Loughran, Aoife McLysaght, Máire Ní Leathlobhair   +2 more
doaj   +3 more sources

Chromosomal Instability and Periodontal Disease in Idiopathic Infertility: Evidence of a Possible Association [PDF]

Biology
Background: Chromosomal instability (CIN) may underlie a subset of idiopathic infertility, and chronic periodontitis could contribute to genomic fragility.
Cristina-Crenguţa Albu, Ştefan-Dimitrie Albu, Claudia Florina Bogdan-Andreescu, Cristian-Viorel Poalelungi, Constantin Marian Damian, Alexandru Burcea, Andreea-Mariana Bănățeanu, Emin Cadar, Dan Alexandru Slăvescu, Anca Daniela Brăila   +9 more
doaj   +2 more sources

Chromosomal instability, aneuploidy, and cancer [PDF]

Frontiers in Oncology, 2014
The link between aneuploidy and cancer has been recognized overa century ago (1). Abnormalities in chromosome copy numbersarise from persistent errors in chromosome segregation dur-ing cell division, a process known as chromosomal instability(CIN) (2).
Samuel F Bakhoum, Charles eSwanton
doaj   +3 more sources

Chromosome instability syndromes [PDF]

Nature Reviews Disease Primers, 2019
Fanconi anaemia (FA), ataxia telangiectasia (A-T), Nijmegen breakage syndrome (NBS) and Bloom syndrome (BS) are clinically distinct, chromosome instability (or breakage) disorders. Each disorder has its own pattern of chromosomal damage, with cells from these patients being hypersensitive to particular genotoxic drugs, indicating that the underlying ...
Taylor, A. Malcolm R., Rothblum-Oviatt, Cynthia, Ellis, Nathan A., Hickson, Ian D., Meyer, Stefan, Crawford, Thomas O., Smogorzewska, Agata, Pietrucha, Barbara, Weemaes, Corry, Stewart, Grant S.   +9 more
openaire   +10 more sources

Chromosomal Instability in Meningiomas [PDF]

Journal of Neuropathology & Experimental Neurology, 2005
Approximately 60% of sporadic meningiomas are caused by inactivation of the NF2 tumor suppressor gene on chromosome 22. No causative gene is known for the remaining 40%. Cytogenetic analysis shows that meningiomas caused by inactivation of the NF2 gene can be divided into tumors that show monosomy 22 as the sole abnormality and tumors with a more ...
Tilborg, Angela, Al Allak, B, Velthuizen, Sandra, de Vries, A (Annie), Kros, J.M., Avezaat, CJJ, de Klein, Annelies, Beverloo, Berna, Zwarthoff, Ellen   +8 more
openaire   +3 more sources

Telomeres and chromosome instability [PDF]

DNA Repair, 2006
Genomic instability has been proposed to play an important role in cancer by accelerating the accumulation of genetic changes responsible for cancer cell evolution. One mechanism for chromosome instability is through the loss of telomeres, which are DNA-protein complexes that protect the ends of chromosomes and prevent chromosome fusion.
Bailey, Susan M, Murnane, John P
openaire   +6 more sources

Mechanisms of Chromosomal Instability [PDF]

Current Biology, 2010
Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by ...
Thompson, Sarah L., Bakhoum, Samuel F., Compton, Duane A.   +2 more
openaire   +2 more sources

Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells. [PDF]

PLoS ONE, 2012
Chromosomal instability is the major form of genomic instability in cancer cells. Amongst various forms of chromosomal instability, pericentromeric or centromeric instability remains particularly poorly understood.
Wen Deng, Sai Wah Tsao, Xin-Yuan Guan, Annie L M Cheung   +3 more
doaj   +1 more source

Multi-layered cancer chromosomal instability phenotype

Frontiers in Oncology, 2013
Whole chromosomal instability (W-CIN) – unequal chromosome distribution during cell division - is a characteristic feature of a majority of cancer cells distinguishing them from their normal counterparts.
Anna V Roschke, Ester eRozenblum
doaj   +1 more source

Cytogenetic studies of Myodes glareolus from the natural populations of the Chornobyl Exclusion Zone in the remote post-accident period [PDF]

Ядерна фізика та енергетика, 2022
The results of cytogenetic studies of bank voles (Myodes glareolus) carried out during 2009 - 2016 in the areas of the Chornobyl Exclusion Zone with different levels of radionuclide contamination are presented.
N. M. Riabchenko, O. O. Burdo, A. I. Lypska   +2 more
doaj   +1 more source