Results 11 to 20 of about 93,154 (303)

Telomere-Dependent Chromosomal Instability [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2005
Telomeres are specialized DNA-protein structures at the ends of the linear chromosomes. In mammalian cells, they are composed of multifold hexameric TTAGGG repeats and a number of associated proteins. The double-stranded telomeric DNA ends in a 3' single stranded overhang of 150 to 300 base pair (bp) which is believed to be required for a higher order ...
Boukamp, Petra, Popp, Susanne, Krunic, Damir   +2 more
openaire   +3 more sources

Mechanisms of Chromosomal Instability [PDF]

Current Biology, 2010
Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by ...
Thompson, Sarah L., Bakhoum, Samuel F., Compton, Duane A.   +2 more
openaire   +3 more sources

Chromosomal instability and human hepatocarcinogenesis. [PDF]

Histology and histopathology, 2003
Recently, many studies have identified losses and gains of several chromosomal loci in human hepatocellular carcinoma (HCC) with fine microsatellite analysis and comparative genomic hybridization. Although distribution of aberrant chromosomal arms differs among HCCs, loss of 1p, 4q, 6q, 8p, 9p, 10q, 13q, 16q and 17p, and gain of 1q, 6p, 8q, 17q and 20q
Nishida, N., Nishimura, T., Ito, T., Komeda, T., Fukuda, Y., Nakao, K.   +5 more
openaire   +4 more sources

Short-term molecular consequences of chromosome mis-segregation for genome stability

Nature Communications, 2023
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, Martina Galli, Marie Dumont, Yonatan Eliezer, René Wardenaar, Marica Rosaria Ippolito, Divya Ramalingam Iyer, Andréa E. Tijhuis, Diana C. J. Spierings, Michael Schubert, Silvia Taglietti, Chiara Soriani, Simon Gemble, Renata Basto, Nick Rhind, Floris Foijer, Uri Ben-David, Daniele Fachinetti, Ylli Doksani, Stefano Santaguida   +21 more
doaj   +1 more source

Telomeres and chromosome instability [PDF]

DNA Repair, 2006
Genomic instability has been proposed to play an important role in cancer by accelerating the accumulation of genetic changes responsible for cancer cell evolution. One mechanism for chromosome instability is through the loss of telomeres, which are DNA-protein complexes that protect the ends of chromosomes and prevent chromosome fusion.
Bailey, Susan M, Murnane, John P
openaire   +6 more sources

Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers

Cancer Reports, 2023
Background Cancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive.
Sasha Taluri, Vishal H. Oza, Tabea M. Soelter, Jennifer L. Fisher, Brittany N. Lasseigne   +4 more
doaj   +1 more source

Genome-wide chromosomal instability by cell-free DNA sequencing predicts survival in patients with metastatic breast cancer

Breast, 2020
Background: Genome-wide chromosomal instability, instead of specific somatic mutations or copy-number alterations in selected genes, is a significant property of cancer and may suggest a new strategy for treatment.
Hongnan Mo, Xiaobing Wang, Fei Ma, Ziliang Qian, Xiaoying Sun, Zongbi Yi, Xiuwen Guan, Lixi Li, Binliang Liu, Binghe Xu   +9 more
doaj   +1 more source

Perceived Stress Levels, Chemotherapy, Radiation Treatment and Tumor Characteristics Are Associated with a Persistent Increased Frequency of Somatic Chromosomal Instability in Women Diagnosed with Breast Cancer: A One Year Longitudinal Study. [PDF]

PLoS ONE, 2015
While advances in therapeutic approaches have resulted in improved survival rates for women diagnosed with breast cancer, subsets of these survivors develop persistent psychoneurological symptoms (fatigue, depression/anxiety, cognitive dysfunction) that ...
Noran Aboalela, Debra Lyon, R K Elswick, Debra Lynch Kelly, Jenni Brumelle, Harry D Bear, Colleen Jackson-Cook   +6 more
doaj   +1 more source

Chromosomal instability of purebred and crossbred dairy cows

, 2022
The article presents the results of research on the karyotype characteristics variability in purebred and crossbred dairy cows. The material for the research was peripheral blood samples of purebred firstborn cows of the Ukrainian red-spotted dairy and ...
V. Dzitsiuk, L. Starodub, T. Dyman
core   +1 more source

Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes [PDF]

, 2010
Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division.
Chaplin Tracy, Teh, MT, Muy-Teck Teh, Young Bryan D, Gemenetzidis, E, Teh Muy-Teck, Bryan D Young, Philpott Michael P, Emilios Gemenetzidis, Gemenetzidis Emilios, Chaplin, T, Young, BD, Michael P Philpott, Philpott, MP, Tracy Chaplin   +14 more
core   +1 more source