Results 11 to 20 of about 157,687 (296)

Chromosome instability syndromes

Best Practice & Research Clinical Haematology, 2001
The chromosome instability syndromes, ataxia telangiectasia (A-T), Fanconi anaemia (FA) and Bloom syndrome (BS) have been known for many years. More recently Nijmegen breakage syndrome (NBS) and ataxia telangiectasia-like disorder (ATLD) have been identified.
Orlando J. Miller, Eeva Therman
  +6 more sources

Short-term molecular consequences of chromosome mis-segregation for genome stability

Nature Communications, 2023
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, Martina Galli, Marie Dumont, Yonatan Eliezer, René Wardenaar, Marica Rosaria Ippolito, Divya Ramalingam Iyer, Andréa E. Tijhuis, Diana C. J. Spierings, Michael Schubert, Silvia Taglietti, Chiara Soriani, Simon Gemble, Renata Basto, Nick Rhind, Floris Foijer, Uri Ben-David, Daniele Fachinetti, Ylli Doksani, Stefano Santaguida   +21 more
doaj   +1 more source

Chromosomal Instability in Meningiomas [PDF]

Journal of Neuropathology & Experimental Neurology, 2005
Approximately 60% of sporadic meningiomas are caused by inactivation of the NF2 tumor suppressor gene on chromosome 22. No causative gene is known for the remaining 40%. Cytogenetic analysis shows that meningiomas caused by inactivation of the NF2 gene can be divided into tumors that show monosomy 22 as the sole abnormality and tumors with a more ...
Tilborg, Angela, Al Allak, B, Velthuizen, Sandra, de Vries, A (Annie), Kros, J.M., Avezaat, CJJ, de Klein, Annelies, Beverloo, Berna, Zwarthoff, Ellen   +8 more
openaire   +3 more sources

Inferring chromosomal instability from copy number aberrations as a measure of chromosomal instability across human cancers

Cancer Reports, 2023
Background Cancer is a complex disease that is the second leading cause of death in the United States. Despite research efforts, the ability to manage cancer and select optimal therapeutic responses for each patient remains elusive.
Sasha Taluri, Vishal H. Oza, Tabea M. Soelter, Jennifer L. Fisher, Brittany N. Lasseigne   +4 more
doaj   +1 more source

Characterization of Chromosomal Instability in Glioblastoma

Frontiers in Genetics, 2022
Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system (CNS). The poor prognosis of GBM due to resistance to therapy has been associated with high chromosomal instability (CIN).
Elisa Balzano, Elisa Balzano, Elena Di Tommaso, Elena Di Tommaso, Antonio Antoccia, Franca Pelliccia, Simona Giunta   +6 more
doaj   +1 more source

Genome-wide chromosomal instability by cell-free DNA sequencing predicts survival in patients with metastatic breast cancer

Breast, 2020
Background: Genome-wide chromosomal instability, instead of specific somatic mutations or copy-number alterations in selected genes, is a significant property of cancer and may suggest a new strategy for treatment.
Hongnan Mo, Xiaobing Wang, Fei Ma, Ziliang Qian, Xiaoying Sun, Zongbi Yi, Xiuwen Guan, Lixi Li, Binliang Liu, Binghe Xu   +9 more
doaj   +1 more source

Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis [PDF]

, 2015
Cyclin D1 is an important molecular driver of human breast cancer but better understanding of its oncogenic mechanisms is needed, especially to enhance efforts in targeted therapeutics.
Addya, Sankar, Arnold, Andrew, Cardiff, Robert D, Casimiro, Mathew C, Crosariol, Marco, Dampier, William, Di Sante, Gabriele, Ertel, Adam, FORTINA, PAOLO, Knudsen, Erik S, Li, Zhiping, Lisanti, Michael P, Loro, Emanuele, Papanikolaou, Alexandros, Pestell, Richard G., Saria, Elizabeth A, Tozeren, Aydin, Wang, Chenguang, Yu, Zuoren   +18 more
core   +1 more source

Chromosomal instability in adult-type diffuse gliomas

Acta Neuropathologica Communications, 2022
Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying mechanism of tumorigenesis and malignant progression, and has been documented in a wide variety of cancers, including colorectal carcinoma with mutations in genes such
Timothy E. Richardson, Jamie M. Walker, Kalil G. Abdullah, Samuel K. McBrayer, Mariano S. Viapiano, Zarmeen M. Mussa, Nadejda M. Tsankova, Matija Snuderl, Kimmo J. Hatanpaa   +8 more
doaj   +1 more source

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects. [PDF]

, 2018
Genome instability is associated with tumorigenesis. Here, we identify a role for the histone Htz1, which is deposited by the Swr1 chromatin-remodeling complex (SWR-C), in preventing genome instability in the absence of the replication fork/replication ...
Branzei, Dana, Kolodner, Richard D, Li, Bin-Zhong, Putnam, Christopher D, Srivatsan, Anjana, Szakal, Barnabas   +5 more
core   +2 more sources

Stem-Like Adaptive Aneuploidy and Cancer Quasispecies [PDF]

, 2013
We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms
Napoletani, Domenico, Signore, Michele, Struppa, Daniele C.   +2 more
core   +4 more sources