Results 41 to 50 of about 93,154 (303)
EMBO Molecular Medicine, 2020 Oncogene‐addicted tumors present a valuable target for therapeutic intervention and an opportunity to achieve a wide therapeutic window. Nonetheless, resistance to targeted therapies is frequently observed and it arises through multiple mechanisms ...
Daniel Bronder, Samuel F Bakhoum
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The mitotic origin of chromosomal instability [PDF]
Current Biology, 2014 SummaryChromosomal instability (CIN) is a common feature of most human neoplasms and was defined, in a seminal study by Vogelstein and colleagues [1], as persistently elevated rates of whole chromosome mis-segregation. Since then, it was shown that certain errors in mitosis, including defects in the spindle assembly checkpoint [2], sister chromatid ...
Bakhoum, Samuel F. +5 more
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, 2022 Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
Sebastián Cepeda (12130440) +6 more
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Chromosomal Instability in Gastric Cancer Biology
Neoplasia: An International Journal for Oncology Research, 2017 Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the total cancer incidence. The prognosis of GC is dismal in Western countries due to late diagnosis: approximately 70% of the patients die within 5 years following ...
Saffiyeh Saboor Maleki +1 more
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Chromosome instability in neuroblastoma.
Oncology letters, 2018 Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of
Fusco, Pina +2 more
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Evidence of chromosomal instability in neurofibromatosis [PDF]
Cancer, 1985 Blood lymphocytes from six unrelated patients with neurofibromatosis and three normal controls were examined for their response to different doses (0, 75, 150, 300, 400 rad) of x-radiation, as measured by chromosome aberrations (gaps, breaks, dicentrics, centric rings, acentric ring, fragments, and minutes).
M, Hafez +3 more
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, 2022 Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
Sebastián Cepeda (12130440) +6 more
core +1 more source
Chromosomal instability drives metastasis through a cytosolic DNA response [PDF]
, 2018 Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is a major driver of tumour evolution, its role in metastasis has not been established.
LaPlant, Quincey +98 more
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Molecular mechanism in a rare autosomal recessive case of xeroderma pigmentosum - a case report
National Journal of Clinical Anatomy, 2014 Chromosomal instability syndromes are a special group of disorders of cytogenetic interest which comprises of several rare, autosomal recessive conditions.
Vijaya Ramanathan, Anand Ramanathan
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DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF. [PDF]
PLoS Genetics, 2018 DNA replication stress (DRS) leads to the accumulation of stalled DNA replication forks leaving a fraction of genomic loci incompletely replicated, a source of chromosomal rearrangements during their partition in mitosis.
Rémy Bétous +5 more
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