Results 51 to 60 of about 93,154 (303)
, 2022 Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
Sebastián Cepeda (12130440) +6 more
core +1 more source
Tetraploidy causes chromosomal instability in acentriolar mouse embryos
Nature Communications, 2019 During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability
Lia Mara Gomes Paim, Greg FitzHarris
doaj +1 more source
A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. [PDF]
PLoS ONE, 2008 BackgroundPolyploidy is a prominent feature of many human cancers, and it has long been hypothesized that polyploidy may contribute to tumorigenesis by promoting genomic instability.
Meejeon Roh +4 more
doaj +1 more source
Mechanisms of chromosomal instability in melanoma [PDF]
Environmental and Molecular Mutagenesis, 2014 A systems biology approach was applied to investigate the mechanisms of chromosomal instability in melanoma cell lines. Chromosomal instability was quantified using array comparative genomic hybridization to identify somatic copy number alterations (deletions and duplications).
William K, Kaufmann +8 more
openaire +2 more sources
, 2022 Pesticides are a group of environmental pollutants widely used in agriculture to protect crops, and their indiscriminate use has led to a growing public awareness about the health hazards associated with exposure to these substances. In fact, exposure to
Sebastián Cepeda (12130440) +6 more
core +1 more source
Nucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer
npj Genomic Medicine, 2022 Fragmentation patterns of plasma cell-free DNA (cfDNA) are known to reflect nucleosome positions of cell types contributing to cfDNA. Based on cfDNA fragmentation patterns, the deviation in nucleosome footprints was quantified between diagnosed ovarian ...
Adriaan Vanderstichele +20 more
doaj +1 more source
Drug Targeting of Genomic Instability in Multiple Myeloma
Frontiers in Genetics, 2020 Genomic instability can be observed at both chromosomal and chromatin levels. Instability at the macro level includes centrosome abnormalities (CA) resulting in numerical as well as structural chromosomal changes, whereas instability at the micro level ...
Meral Beksac +2 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
, 2008 Uterine cervical cancer, the second most frequently occurring cancer in women worldwide, is tightly associated with the expression of high-risk human papillomavirus [mainly human papillomavirus (HPV)-16 and HPV18] oncogenes E6 and E7 and ...
Hui, YL +11 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source