Results 51 to 60 of about 85,648 (260)

Telomere-Dependent Chromosomal Instability [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2005
Telomeres are specialized DNA-protein structures at the ends of the linear chromosomes. In mammalian cells, they are composed of multifold hexameric TTAGGG repeats and a number of associated proteins. The double-stranded telomeric DNA ends in a 3' single stranded overhang of 150 to 300 base pair (bp) which is believed to be required for a higher order ...
Boukamp, Petra, Popp, Susanne, Krunic, Damir   +2 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Chromosomal aberrations after induced pluripotent stem cells reprogramming

Genetics and Molecular Biology, 2021
Induced pluripotent stem cells (iPSCs) are generated from adult cells that have been reprogrammed to pluripotency. However, in vitro cultivation and genetic reprogramming increase genetic instability, which could result in chromosomal abnormalities ...
Isadora May Vaz, Tamara Borgonovo, Tais Hanae Kasai-Brunswick, Danúbia Silva dos Santos, Fernanda Cristina Paccola Mesquita, Juliana Ferreira Vasques, Fernanda Gubert, Carmen Lúcia Kuniyoshi Rebelatto, Alexandra Cristina Senegaglia, Paulo Roberto Slud Brofman   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.

PLoS ONE, 2022
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis.
Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers   +10 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

Cell Reports, 2015
Numerical chromosomal instability is a ubiquitous feature of human neoplasms. Due to experimental limitations, fundamental characteristics of karyotypic changes in cancer are poorly understood.
Ashley M. Laughney, Sergi Elizalde, Giulio Genovese, Samuel F. Bakhoum   +3 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Evaluation of predictive biomarkers for late radiation toxicity in breast cancer patients

Scientific Reports
Radiotherapy is administered to 70% of breast cancer patients, but late complications such as breast fibrosis remain a significant clinical concern. Individual variability significantly influences radiosensitivity, underscoring the need for predictive ...
Ángela Solana-Peña, Monica Pujol-Canadell, Miquel Macià, Evelyn Martínez Pérez, Isabel Linares, Milica Stefanovic, Héctor Pérez-Montero, Javier González-Viguera, Marina Arangüena Peñacoba, Montse Ventura, Ferran Guedea, Nadina Erill, Víctor González-Rumayor, Gemma Armengol, Joan Francesc Barquinero Estruch   +14 more
doaj   +1 more source