Results 71 to 80 of about 93,154 (303)

Neuroblastoma Patients’ Outcome and Chromosomal Instability

, 2023
Chromosomal instability (CIN) induces a high rate of losses or gains of whole chromosomes or parts of chromosomes. It is a hallmark of most human cancers and one of the causes of aneuploidy and intra-tumor heterogeneity.
Stefano Parodi, Annalisa Pezzolo, De Marco, Patrizia, Pezzolo, Annalisa, Martina Fragola, Zara, Federico, Parodi, Stefano, Patrizia De Marco, Loredana Amoroso, Ognibene, Marzia, Fragola, Martina, Marzia Ognibene, Federico Zara, Amoroso, Loredana   +13 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Chromosomal aberrations after induced pluripotent stem cells reprogramming

Genetics and Molecular Biology, 2021
Induced pluripotent stem cells (iPSCs) are generated from adult cells that have been reprogrammed to pluripotency. However, in vitro cultivation and genetic reprogramming increase genetic instability, which could result in chromosomal abnormalities ...
Isadora May Vaz, Tamara Borgonovo, Tais Hanae Kasai-Brunswick, Danúbia Silva dos Santos, Fernanda Cristina Paccola Mesquita, Juliana Ferreira Vasques, Fernanda Gubert, Carmen Lúcia Kuniyoshi Rebelatto, Alexandra Cristina Senegaglia, Paulo Roberto Slud Brofman   +9 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

Cell Reports, 2015
Numerical chromosomal instability is a ubiquitous feature of human neoplasms. Due to experimental limitations, fundamental characteristics of karyotypic changes in cancer are poorly understood.
Ashley M. Laughney, Sergi Elizalde, Giulio Genovese, Samuel F. Bakhoum   +3 more
doaj   +1 more source

The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.

PLoS ONE, 2022
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis.
Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers   +10 more
doaj   +1 more source

Deadly role of chromosomal instability in metastasis

, 2018
Chromosomal instability produces cytosolic micronuclei that rupture and activate a viral response pathway, driving metastasis.
Tríona Ní Chonghaile
core   +1 more source

CINflammatory: the multi-layered relationship between chromosomal instability and inflammation [PDF]

, 2022
Chromosomal instability (CIN) is characterized by continuous errors in chromosome segregation during mitosis and is observed frequently in cancer. The process of CIN most of the time leads to structural and numerical chromosome abnormalities, a state ...
Hong, Christy
core   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source