Results 1 to 10 of about 241,247 (399)
A complete telomere-to-telomere assembly of the maize genome
Nature Genetics, 2023 A complete telomere-to-telomere genome assembly of the maize Mo17 inbred line uncovers structural features of the highly complex maize genome. A complete telomere-to-telomere (T2T) finished genome has been the long pursuit of genomic research.
Jian Chen +15 more
semanticscholar +1 more source
Polygenic basis and biomedical consequences of telomere length variation
Nature Genetics, 2021 Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture of naturally occurring variation in leukocyte telomere length (LTL) and identify causal links between LTL ...
V. Codd +27 more
semanticscholar +1 more source
Open Biology, 2022 Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate.
Robert Lu, Hilda A. Pickett
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Stress and telomere shortening: Insights from cellular mechanisms
Ageing Research Reviews, 2021 Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead to disease through many pathways, and research from in vitro studies to human longitudinal studies has pointed to stress-induced telomere damage as an important ...
Jue Lin, E. Epel
semanticscholar +1 more source
Telomere Length Measurement by Molecular Combing
Frontiers in Cell and Developmental Biology, 2020 Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks.
Vivian F. S. Kahl +7 more
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Telomere-to-telomere gapless chromosomes of banana using nanopore sequencing
Communications Biology, 2021 Long-read technologies hold the promise to obtain more complete genome assemblies and to make them easier. Coupled with long-range technologies, they can reveal the architecture of complex regions, like centromeres or rDNA clusters.
Caroline Belser +13 more
semanticscholar +1 more source
eLife, 2020 Telomeres are a significant challenge to DNA replication and are prone to replication stress and telomere fragility. The shelterin component TRF1 facilitates telomere replication but the molecular mechanism remains uncertain.
Rosa Maria Porreca +8 more
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Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. [PDF]
PLoS ONE, 2010 Leukocyte telomere length, an emerging marker of biological age, has been shown to predict cardiovascular morbidity and mortality. However, the natural history of telomere length in patients with coronary artery disease has not been studied. We sought to
Ramin Farzaneh-Far +5 more
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Telomere reprogramming and maintenance in porcine iPS cells. [PDF]
PLoS ONE, 2013 Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases.
Guangzhen Ji +15 more
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Telomere maintenance in African trypanosomes
Frontiers in Molecular Biosciences, 2023 Telomere maintenance is essential for genome integrity and chromosome stability in eukaryotic cells harboring linear chromosomes, as telomere forms a specialized structure to mask the natural chromosome ends from DNA damage repair machineries and to ...
Bibo Li, Bibo Li, Bibo Li, Bibo Li
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