Results 1 to 10 of about 2,052,365 (293)
Newborn telomere length predicts later life telomere length: Tracking telomere length from birth to child- and adulthood [PDF]
EBioMedicine, 2021 Background: Telomere length (TL) is considered a biological marker of aging and may indicate age-related disease susceptibility. Adults and children show a fixed ranking and tracking of TL over time.
Dries S. Martens +5 more
doaj +8 more sources
Inheritance of telomere length in a bird. [PDF]
PLoS ONE, 2011 Telomere dynamics are intensively studied in human ageing research and epidemiology, with many correlations reported between telomere length and age-related diseases, cancer and death. While telomere length is influenced by environmental factors there is
Thorsten Horn +5 more
doaj +6 more sources
Frontiers in Oncology, 2022 The number of (TTAGGG)n repeats at the ends of chromosomes is highly variable between individual chromosomes, between different cells and between species. Progressive loss of telomere repeats limits the proliferation of pre-malignant human cells but also
Peter Lansdorp, Peter Lansdorp
doaj +3 more sources
Telomeres and Telomere Length: A General Overview [PDF]
Cancers, 2020 Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Rajiv Kumar +2 more
exaly +3 more sources
Telomere Length Measurement by Molecular Combing
Frontiers in Cell and Developmental Biology, 2020 Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks.
Vivian F. S. Kahl +7 more
doaj +3 more sources
A mechanism for telomere-specific telomere length regulation. [PDF]
Nucleic Acids ResSUMMARY Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases.
Teplitz GM +8 more
europepmc +7 more sources
PLoS Genetics, 2006 Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes and pathways that regulate telomere length. We found 72 genes that when deleted confer short telomeres, and 80 genes that confer long telomeres relative ...
Tonibelle Gatbonton +7 more
doaj +4 more sources
Telomere Length and Male Fertility [PDF]
International Journal of Molecular Sciences, 2021 Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters.
Gentiluomo M. +8 more
openaire +4 more sources
Open Biology, 2022 Telomeres are nucleoprotein structures that cap the ends of linear chromosomes. Telomeric DNA comprises terminal tracts of G-rich tandem repeats, which are inherently difficult for the replication machinery to navigate.
Robert Lu, Hilda A. Pickett
doaj +1 more source
Nursing Research, 2014 The exciting discovery that telomere shortening is associated with many health conditions and that telomere lengths can be altered in response to social and environmental exposures has underscored the need for methods to accurately and consistently quantify telomere length.The purpose of this article is to provide a comprehensive summary that compares ...
Alison J, Montpetit +10 more
openaire +5 more sources