Results 1 to 10 of about 57,792 (238)
Targeting Telomerase in Cancer: Vaccine-Based Strategies, Clinical Evidence, and Synergy with Immunotherapy [PDF]
DiseasesWith each replication cycle, telomeres shorten. Telomerase can slow or reverse the rate of telomere shortening. In the era of cancer immunotherapy, telomerase is a promising tumor-associated antigen due to its widespread and specific expression in cancer
Stella Baliou +9 more
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Early differential responses elicited by BRAFV600E in adult mouse models
Cell Death and Disease, 2022 The BRAF gene is frequently mutated in cancer. The most common genetic mutation is a single nucleotide transition which gives rise to a constitutively active BRAF kinase (BRAFV600E) which in turn sustains continuous cell proliferation.
Giuseppe Bosso +5 more
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Nature Communications, 2022 Telomere dysfunction induced by TRF1 depletion in fibroblasts, club and basal cells did not lead to interstitial lung fibrosis, underscoring alveolar type II cells as the relevant cell type in pulmonary fibrosis.
Sergio Piñeiro-Hermida +7 more
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Molecular Oncology, 2021 Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere‐independent functions of human TERT have been described.
Manuel Bernabé‐García +8 more
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Cost-Effective Trap qPCR Approach to Evaluate Telomerase Activity: an Important Tool for Aging, Cancer, and Chronic Disease Research [PDF]
Clinics, 2021 OBJECTIVES: Telomeres are a terminal “DNA cap” that prevent chromosomal fusion and degradation. However, aging is inherent to life, and so is the loss of terminal sequences.
Thalyta Nery Carvalho Pinto +4 more
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The mTOR pathway is necessary for survival of mice with short telomeres
Nature Communications, 2020 Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.
Iole Ferrara-Romeo +10 more
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eLife, 2019 The mechanisms that regulate pluripotency are still largely unknown. Here, we show that Telomere Repeat Binding Factor 1 (TRF1), a component of the shelterin complex, regulates the genome-wide binding of polycomb and polycomb H3K27me3 repressive marks to
Rosa María Marión +7 more
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Molecular Oncology, 2023 Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively ...
Jing Wang +8 more
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Nature Communications, 2016 Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing ...
Elisa Varela +4 more
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Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation
Cell Reports, 2014 Sox4 expression is restricted in mammals to embryonic structures and some adult tissues, such as lymphoid organs, pancreas, intestine, and skin. During embryogenesis, Sox4 regulates mesenchymal and neural progenitor survival, as well as lymphocyte and ...
Miguel Foronda +7 more
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