Results 1 to 10 of about 78,599 (266)

Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

eLife, 2016
We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways.
Jacob M Vogan, Xiaozhu Zhang, Daniel T Youmans, Samuel G Regalado, Joshua Z Johnson, Dirk Hockemeyer, Kathleen Collins   +6 more
doaj   +1 more source

Therapeutic inhibition of TRF1 impairs the growth of p53‐deficient K‐RasG12V‐induced lung cancer by induction of telomeric DNA damage

EMBO Molecular Medicine, 2015
Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer‐prone mouse models, however, only decreased tumor growth after several mouse generations when ...
María García‐Beccaria, Paula Martínez, Marinela Méndez‐Pertuz, Sonia Martínez, Carmen Blanco‐Aparicio, Marta Cañamero, Francisca Mulero, Chiara Ambrogio, Juana M Flores, Diego Megias, Mariano Barbacid, Joaquín Pastor, Maria A Blasco   +12 more
doaj   +1 more source

The role of telomere and telomerase in cancer and novel therapeutic target: narrative review

Frontiers in Oncology
Telomeres are dynamic complexes at the ends of chromosomes that are made up of protective proteins and tandem repeating DNA sequences. In the large majority of cancer cells, telomere length is maintained by telomerase, an enzyme that elongates telomeres.
Temesgen Baylie, Mohammed Jemal, Gelagay Baye, Mamaru Getinet, Gashaw Azanaw Amare, Adane Adugna, Desalegn Abebaw, Zigale Hibstu, Bantayehu Addis Tegegne, Endalkachew Gugsa, Tadegew Adane, Gedefaw Getie, Baye Ashenef, Deresse Sinamaw   +13 more
doaj   +1 more source

Recent progress in human telomerase structure and its therapeutic targeting

Frontiers in Molecular Biosciences
Most cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori, Abdulrahman Awad, Sarah Dhaiban, Mohammed Turki Alduhoori, Humayun Sharif, Abdulrahim Sajini   +5 more
doaj   +1 more source

The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation

Scientific Reports, 2017
Telomerase activity is not readily detected in resting human T lymphocytes, however upon antigen presentation, telomerase is transiently upregulated. Presently, it is not known if telomerase activation is necessary for the proliferation of T cells or for
Ejun (Elijah) Huang, Enzo Tedone, Ryan O’Hara, Crystal Cornelius, Tsung-Po Lai, Andrew Ludlow, Woodring E. Wright, Jerry W. Shay   +7 more
doaj   +1 more source

Modulation of telomere protection by the PI3K/AKT pathway

Nature Communications, 2017
Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.
Marinela Méndez-Pertuz, Paula Martínez, Carmen Blanco-Aparicio, Elena Gómez-Casero, Ana Belen García, Jorge Martínez-Torrecuadrada, Marta Palafox, Javier Cortés, Violeta Serra, Joaquin Pastor, Maria A. Blasco   +10 more
doaj   +1 more source

Telomerase – future drug target enzyme?

Zdravniški Vestnik, 2012
Eucaryotic chromosome endings (telomeres) replication problem was solved in the 1980’s by discovery of the telomerase enzyme. The Nobel Prize in Physiology or Medicine was awarded in 2009 for the discovery of telomerase.
Tomaž Langerholc
doaj  

Extracellular vesicles for delivery of functional telomerase

Cell Communication and Signaling
Background Telomerase, essential for maintaining chromosomal telomere integrity and preventing cellular senescence, represents a promising therapeutic target.
Yingying He, Yumeng Cui, Lijuan Wang, Wen Yang, Ruping Wang, Yanghua Li, Yue Ma, Yanli Lin, Xiaojie Wu, Long Cheng, Chengjiang Zhou, Youliang Wang   +11 more
doaj   +1 more source

Telomerase activity in human hematopoietic progenitor cells

Haematologica, 1997
BACKGROUND AND OBJECTIVE: Telomerase is the enzyme that stabilizes and elongates the telomeric ends of chromosomes. It is expressed in germline and malignant cells and absent in most human somatic cells.
S Hohaus, MT Voso, E Orta-La Barbera, S Cavallo, A Bellacosa, S Rutella, C Rumi, M Genuardi, G Neri, G Leone   +9 more
doaj  

Alternative lengthening of telomeres is dependent on RAD52 and RAD51 gene function in the budding yeast Naumovozyma castellii. [PDF]

G3 (Bethesda)
Itriago H, Cohn M.
europepmc   +1 more source