Results 1 to 10 of about 367,784 (212)
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms. [PDF]
PLoS Computational Biology, 2014 Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
Alan E Bilsland +6 more
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TERT—Regulation and Roles in Cancer Formation
Frontiers in Immunology, 2020 Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase complex plays a key role in cancer formation by telomere dependent or independent mechanisms.
Marta Dratwa +2 more
exaly +3 more sources
Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration
Cell Reports, 2017 Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert+ intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (TertTCE/+) mouse model, we
Moon Jong Kim +2 more
exaly +3 more sources
Two co-inherited SNPs of the telomerase reverse transcriptase (TERT) gene are associated with Iraqi patients with lung cancer [PDF]
Journal of Medical Biochemistry, 2023 Background: The telomerase reverse transcriptase (TERT) gene is essential polymorphic loci linked to most malignant tumors. This study assessed the association between the TERT gene and non-small cell lung carcinoma (NSCLC) in Iraq.
Lawi Zahraa K. +4 more
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Acta Medica Bulgarica, 2021 Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development.
Vidinov K. +8 more
doaj +1 more source
Türk Patoloji Dergisi, 2023 Objective: Primary anorectal melanomas (AMs) are uncommon neoplasms with aggressive behavior. Molecular profile and clinicopathologic features of AMs are still not well established.
Orhun Cig TASKIN +6 more
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Indian Journal of Ophthalmology, 2022 Purpose: Mutations in human telomerase reverse transcriptase (TERT) are associated with increased telomerase activity in cutaneous melanomas. Conjunctival squamous cell carcinoma, also referred to as ocular surface squamous cell carcinoma, is cancer on ...
Perumal Jayaraj +7 more
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tert-Butoxytriphenylsilane [PDF]
Acta Crystallographica Section E Structure Reports Online, 2010 The title compound, C(22)H(24)OSi or Ph(3)SiO(t)Bu, shows a distorted tetra-hedral coordination sphere around the Si atom. The C-O-Si angle is 135.97 (12)° and the O-Si distance is 1.6244 (13) Å. The mol-ecules are held together by weak inter-actions only. An H⋯H distance of 2.2924 (7) Å is found between aryl H atoms and is the shortest inter-molecular
Jonathan O. Bauer, Carsten Strohmann
openaire +3 more sources
European Thyroid Journal, 2023 Background: Successful radioiodine treatment of differentiated thyroid canc er requires iodine avidity: that is, the concentration and retention of iodine in cancer tissue. Several parameters have previously been linked with lower iodine avidity. However,
Joachim N Nilsson +7 more
doaj +1 more source
Polish Journal of Pathology, 2021 Gray zone thyroid tumors for which benignity or malignancy cannot be assessed are constantly increasing and accurate prediction of their malignant behavior is vital to avoid both violent surgical intervention for benign tumors and lax treatment of ...
Mohamed A. Alabiad +5 more
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