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Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation [PDF]
Biomedicines, 2023 Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template.
Anastasia I. Palamarchuk +2 more
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LARP7 family proteins have conserved function in telomerase assembly [PDF]
Nature Communications, 2018 The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.
Laura C. Collopy +11 more
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Telomerase reverse transcriptase and neurodegenerative diseases [PDF]
Frontiers in Immunology, 2023 Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS).
Xin Yu +5 more
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The regulations of telomerase reverse transcriptase (TERT) in cancer [PDF]
Cell Death and DiseaseAbnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu +7 more
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Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage [PDF]
PeerJ, 2022 Background Angiogenesis is an endogenous repair mechanism following hypoxic-ischemic brain damage (HIBD). Interestingly, recent studies have shown that angiogenesis can be regulated by telomerase reverse transcriptase (TERT), a critical component of ...
Jiao Li +4 more
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Mitochondrial Telomerase Reverse Transcriptase, a Target for Cardiovascular Disease? [PDF]
Function, 2022 Keiichi Torimoto, Satoru Eguchi
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TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly
Cell Reports, 2023 Summary: Localization of a variety of RNAs to non-membrane-bound cellular compartments such as nucleoli and Cajal bodies is critical for their stability and function.
Basma M. Klump +7 more
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Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]
Jichu yixue yu linchuang, 2021 Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
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Nature Communications, 2022 Most eukaryotes maintain telomeres using a specialized reverse transcriptase. Here the authors report that Thc1 (Telomerase Holoenzyme Component 1) and Bmc1 (Bin3/MePCE 1) form a complex with Pof8, a constitutive member of telomerase in fission yeast.
Diego J. Páez-Moscoso +7 more
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Bangabandhu Sheikh Mujib Medical University Journal, 2016 Retinol molecule was modified to predict the inhibitors of telomerase reverse transcriptase for the treatment of arsenical cancer through in silico study. Telomerase activity is expressed in the cancerous conditions which can be the target for anticancer
Kipchu Tshering, Mir Misbahuddin
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