Telomerase reverse transcriptase and neurodegenerative diseases [PDF]
Frontiers in Immunology, 2023 Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS).
Xin Yu +5 more
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Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation [PDF]
Biomedicines, 2023 Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template.
Anastasia I. Palamarchuk +2 more
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The regulations of telomerase reverse transcriptase (TERT) in cancer [PDF]
Cell Death and DiseaseAbnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu +7 more
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Human telomerase reverse transcriptase supports respiratory syncytial virus replication [PDF]
Communications BiologyRespiratory syncytial virus (RSV), discovered in 1956 and identified in children in 1957, is the major respiratory pathogen of infants and children under the age of 5 worldwide.
HoangDinh Huynh +2 more
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Template definition by Tetrahymena telomerase reverse transcriptase [PDF]
EMBO Journal, 2000 The ribonucleoprotein enzyme telomerase extends chromosome ends by copying a specific template sequence within its integral RNA component. An active recombinant telomerase RNP is minimally composed of this RNA and the telomerase reverse transcriptase (TERT) protein, which contains sequence motifs conserved among viral reverse transcriptases (RTs ...
Kathleen Collins
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Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage [PDF]
PeerJ, 2022 Background Angiogenesis is an endogenous repair mechanism following hypoxic-ischemic brain damage (HIBD). Interestingly, recent studies have shown that angiogenesis can be regulated by telomerase reverse transcriptase (TERT), a critical component of ...
Jiao Li +4 more
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Mitochondrial Telomerase Reverse Transcriptase, a Target for Cardiovascular Disease? [PDF]
Function, 2022 Keiichi Torimoto, Satoru Eguchi
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TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly
Cell Reports, 2023 Summary: Localization of a variety of RNAs to non-membrane-bound cellular compartments such as nucleoli and Cajal bodies is critical for their stability and function.
Basma M. Klump +7 more
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The telomerase reverse transcriptase: components and regulation [PDF]
Genes & Development, 1998 The idea that chromosomes have special terminal structures first arose as a consequence of experiments conducted by Muller, who found that treatment of Drosophila with X-rays rarely resulted in terminal deletions or inversions of the chromosomes (Muller 1938).
C I, Nugent, V, Lundblad
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Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]
Jichu yixue yu linchuang, 2021 Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
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