Results 1 to 10 of about 28,516 (233)

The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies

Balkan Medical Journal, 2013
Background: Telomeres are essential for the function and stability of eukaryotic chromosomes. Telomerase consists of three subunits: human telomerase reverse transcriptase (hTERT), human telomerase RNA (hTR), and telomerase protein 1 (TP1).
İlhami Gül, Özgür Dündar, Levent Tütüncü, Serkan Bodur, Yusuf Tunca   +4 more
doaj   +1 more source

Telomerase reverse transcriptase gene amplification in hematological malignancies

Egyptian Journal of Medical Human Genetics, 2019
Background Telomere is a complex DNA–protein structure located at the end of all eukaryotic chromosomes. The major role of human telomerase is to catalyze the addition of telomeric repeat sequences TTAGGG onto chromosome ends for stabilization of ...
Amany H. Abdelrahman, Maha M. Eid, Mirhane Hassan, Ola M. Eid, Rania M. A. AbdelKader, Nevin M. AlAzhary, Rasha Y. Shahin, Mohamed T. Sallam   +7 more
doaj   +1 more source

Alternative Splicing of Human Telomerase Reverse Transcriptase May Not Be Involved in Telomerase Regulation During all-trans-Retinoic Acid-Induced HL-60 Cell Differentiation

Journal of Pharmacological Sciences, 2004
Alternative splicing of the human telomerase reverse transcriptase subunit (hTERT) suppresses telomerase activity during the development of human fetal kidney cells into mature cells.
Wei-Jun Liu, Yong-Wei Zhang, Zhi-Xiang Zhang, Jian Ding   +3 more
doaj   +1 more source

Proteomic identification of proteins differentially expressed following overexpression of hTERT (human telomerase reverse transcriptase) in cancer cells. [PDF]

PLoS ONE, 2017
Reverse transcriptase activity of telomerase adds telomeric repeat sequences at extreme ends of the newly replicated chromosome in actively dividing cells.
Rishi Kumar Jaiswal, Pramod Kumar, Amod Sharma, Deepak Kumar Mishra, Pramod Kumar Yadava   +4 more
doaj   +1 more source

Study on immortalization of Mongolian sheep fibroblast cells

Animal Biotechnology
This study aims to establish an immortalized fibroblast cell line from Mongolian sheep. Primary Mongolian sheep fibroblasts (SSF) were isolated using tissue explant and enzymatic digestion methods, followed by microscopic observation, growth curve ...
Bin. Liu, Shichao. Wang, Fanhua. Meng, Bei. Wu, Yanru Zhang, Junwei. Cao   +5 more
doaj   +1 more source

The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth

Neoplasia: An International Journal for Oncology Research, 2013
Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies.
Agni Christodoulidou, Christina Raftopoulou, Maria Chiourea, George K. Papaioannou, Hirotoshi Hoshiyama, Woodring E. Wright, Jerry W. Shay, Sarantis Gagos   +7 more
doaj   +1 more source

Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle

Nature Communications
In most eukaryotes, the reverse transcriptase telomerase counteracts telomere shortening by processively adding telomeric DNA repeat sequences to chromosome ends.
Sebastian Balch, Elsa Franco-Echevarría, George E. Ghanim, Rachael C. Kretsch, Rhiju Das, Thi Hoang Duong Nguyen   +5 more
doaj   +1 more source

Telomerase: An exploration toward the end of cancer

Indian Journal of Dental Research, 2017
Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells.
Deepika Bablani Popli, Keya Sircar, Aman Chowdhry   +2 more
doaj   +1 more source

The T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase wild-type A case report

Acta Radiologica Open, 2023
We present a case of the T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase (IDH )-wild type. The T2-FLAIR mismatch sign is known as a highly specific imaging finding of astrocytoma, IDH -mutant.
Shunsuke Nishimura, Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Hidetaka Yamamoto, Koji Yoshimoto, Kousei Ishigami   +7 more
doaj   +1 more source

The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo [PDF]

PeerJ, 2016
Telomerase core enzyme minimally consists of the telomerase reverse transcriptase domain-containing protein (Est2 in budding yeast S. cerevisiae) and telomerase RNA, which contains the template specifying the telomeric repeat sequence synthesized.
Tet Matsuguchi, Elizabeth Blackburn
doaj   +2 more sources