Results 31 to 40 of about 28,516 (233)

Regulation of the human telomerase reverse transcriptase gene [PDF]

Oncogene, 2002
Most somatic human cells lack telomerase activity because they do not express the telomerase reverse transcriptase (hTERT) gene. Conversely, most cancer cells express hTERT and are telomerase positive. For most tumors it is not clear whether hTERT expression is due to their origin from telomerase positive stem cells or to reactivation of the gene ...
Anne-Lyse, Ducrest, Henrietta, Szutorisz, Joachim, Lingner, Markus, Nabholz   +3 more
openaire   +2 more sources

Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer

Balkan Medical Journal, 2017
Aims: To investigate the changes in mRNA expression levels of telomerase-related significant proteins in several types of cancer. Methods: Human telomerase reverse transcriptase, pontin, reptin and dyskerin expressions were measured in normal and tumour
Emel Çalışkan Can, M. Can Atalay, Ece Miser Salihoğlu, Ülkü Yalçıntaş Arslan, H. Bolkan Şimşek, Sevgi Yardım Akaydın   +5 more
doaj   +1 more source

Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis

, 2021
Telomeres protect genomic stability and shortening is one of the hallmarks of ageing. Telomerase reverse transcriptase (TERT) is the major protein component of telomerase, which elongates telomeres.
Denham, Joshua, Sellami, Maha
core   +1 more source

AZT as a telomerase inhibitor

Frontiers in Oncology, 2012
Telomerase is a highly specialized reverse transcriptase and the maintenance of telomeric length is determined by this specific enzyme. The human holoenzyme telomerase is a ribonucleoprotein composed by a catalytic subunit, hTERT, an RNA component, hTR ...
Daniel E Gomez, Romina G Armando, Daniel F. eAlonso   +2 more
doaj   +1 more source

CDK1 dependent phosphorylation of hTERT contributes to cancer progression

Nature Communications, 2020
Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for ...
Mami Yasukawa, Yoshinari Ando, Taro Yamashita, Yoko Matsuda, Shisako Shoji, Masaki Suimye Morioka, Hideya Kawaji, Kumiko Shiozawa, Mitsuhiro Machitani, Takaya Abe, Shinji Yamada, Mika K. Kaneko, Yukinari Kato, Yasuhide Furuta, Tadashi Kondo, Mikako Shirouzu, Yoshihide Hayashizaki, Shuichi Kaneko, Kenkichi Masutomi   +18 more
doaj   +1 more source

In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs.

PLoS ONE, 2012
Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie, Naresh R Thumati, Hélène C F Côté, Judy M Y Wong   +3 more
doaj   +1 more source

Insertion of retrotransposons at chromosome ends: adaptive response to chromosome maintenance

Frontiers in Genetics, 2016
The telomerase complex is a specialized reverse transcriptase that inserts tandem DNA arrays at the linear chromosome ends and contributes to the protection of the genetic information in eukaryotic genomes.
Geraldine eServant, Prescott L Deininger
doaj   +1 more source

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. [PDF]

, 2004
The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear.
Beverley, PCL, Catherine H. Orteu, Peter C.L. Beverley, Graham R. Foster, Jackson, SE, Fletcher, JM, Reed, JR, Maria Vieira D. Soares, Soares, MVD, Salmon, Michael, Katie E. Birch, Orteu, CH, John R. Reed, Mike Salmon, Birch, KE, Milica Vukmanovic-Stejic, Jean M. Fletcher, Arne N. Akbar, Beverley, Peter, Soarees, MV, Akbar, AN, Joanne E. Cook, Soares, MV, Rustin, MH, Cook, JE, Beverley, PC, Foster, GR, Salmon, M, Vukmanovic-Stejic, M, Malcolm H.A. Rustin, Rustin, MHA, Sarah E. Jackson   +31 more
core   +1 more source

Telomerase and retrotransposons: Reverse transcriptases that shaped genomes [PDF]

Proceedings of the National Academy of Sciences, 2011
“Two independent groups of investigators have found evidence of an enzyme… which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications… information transfer from DNA to RNA can be inverted.” 1970, preamble to refs. 1 and 2.
Marlene, Belfort, M Joan, Curcio, Neal F, Lue   +2 more
openaire   +2 more sources

A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity.

PLoS Biology, 2019
Telomerase, a unique reverse transcriptase that specifically extends the ends of linear chromosomes, is up-regulated in the vast majority of cancer cells.
Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J Robinson, William P Schiemann, Anthony J Berdis, Emmanuel Skordalakes, Derek J Taylor   +8 more
doaj   +1 more source