Results 31 to 40 of about 570,627 (165)
A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer
Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong +10 morewiley +2 more sourcesAncestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. [PDF]
PLoS Genetics, 2011 The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property known ...Jonathan K Alder, Joy D Cogan, Andrew F Brown, Collin J Anderson, William E Lawson, Peter M Lansdorp, John A Phillips, James E Loyd, Julian J-L Chen, Mary Armanios +9 moredoaj +1 more sourceTelomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. [PDF]
, 2004 The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear.Beverley, PCL, Catherine H. Orteu, Peter C.L. Beverley, Graham R. Foster, Jackson, SE, Fletcher, JM, Reed, JR, Maria Vieira D. Soares, Soares, MVD, Salmon, Michael, Katie E. Birch, Orteu, CH, John R. Reed, Mike Salmon, Birch, KE, Milica Vukmanovic-Stejic, Jean M. Fletcher, Arne N. Akbar, Beverley, Peter, Soarees, MV, Akbar, AN, Joanne E. Cook, Soares, MV, Rustin, MH, Cook, JE, Beverley, PC, Foster, GR, Salmon, M, Vukmanovic-Stejic, M, Malcolm H.A. Rustin, Rustin, MHA, Sarah E. Jackson +31 morecore +1 more sourceLARP7 family proteins have conserved function in telomerase assembly
Nature Communications, 2018 The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.Laura C. Collopy, Tracy L. Ware, Tomas Goncalves, Sunnvør í Kongsstovu, Qian Yang, Hanna Amelina, Corinne Pinder, Ala Alenazi, Vera Moiseeva, Siân R. Pearson, Christine A. Armstrong, Kazunori Tomita +11 moredoaj +1 more sourceFine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression [PDF]
, 2013 Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the ...Hayes, R B, Schumacher, Fredrick, Severi, G., Berndt, S.I., Key, Timothy, Berndt SI, Spurdle A, Dicks, E, Ingles, SA, Le Marchand L, Muir, K; id_orcid, Ingles, S., Albanes, D, Canzian, F., Cybulski, C., Easton DF, Riboli, E., Halim, Silvia, Govindasami, K, Muir, Ken, Conroy, Don, Thobodeau, S.N, Eeles RA, Vogel, W., Muir, K, Hamdy, Freddie C., Leongamornlert, DA, Bacot F, Guy, Michelle, Wilkinson, R.A., Dunning, A.M., Albanes, D., Benlloch, S, Russell R, Clements, Judith A., Key TJ, Al Olama AA, Pharoah P, Morgan, A., Tymrakiewicz, M., Travis RC, Lee, A., Benlloch, S., Hamdy, FC, Stanford, JL, Batra, J., Ingles, Sue A., John, EM, Berndt, Sonja I., Giles, Graham G., Hunter, D.J., Donovan, JL, Wilkinson RA, Thibodeau, Stephen N., Kibel AS, Dadaev T, Luccarini C, Khaw KT, Kraft, P., Gapstur, Susan, Vogel W, Park, Jong Y., Stanford, Janet L., Bojesen SE, Kaneva, Radka, Ostrander, Elaine A., Wilkinson, Rosemary A., Haiman, Christopher A., Batra, J, Ostrander, E A, John EM, Key, Tim J., Schleutker J, Haiman, C.A., Lubinski, Jan, Thibodeau, S N, Lindstrom, S, Schleutker, J, Tessier DC, Key, T J, Maier, C., Le Marchand, Loic, Dunning, AM, John, E.M., Easton, DF, Campa, D., Russel, R, Henderson BE, Ostrander, EA, Spurdle, A., Khaw, KT, Easton, D F, Kaneva, R., Henderson, B E, Hamdy FC, Muir, K.R., Vincent D, Russell, R, Donovan, Jenny, Kraft, P, Khaw, K-T, Clements JA, Guy M, Dennis, Joe, Marchand, LL, Gapstur, S., Sawyer, E.J., Neal, David E., Leongamornlert, D.A., John, Esther M., Albanes, Demetrius, Stanford, J.L., Jugurnauth-Little, Sarah, Kibel, AS, Schaid, D., Cybulski, C, Ingles SA, Govindasami, Koveela, Lubinski, J, Wiklund, F., Donovan JL, Riboli, E, Donovan, J L, Hayes RB, Gronberg, H, Hamdy, F.C., Batra, Jyotsna, Signorello, L.B., Ross Adams H, Campa, Daniele, Gapstur, S, Travis, Ruth, Neal, D E, Wilkinson, RA, Signorello, Lisa B., Key, T.J., Pharoah, P, Muir, Kenneth, Dennis, J, Ghoussaini, M., Lindstrom, S., Neal, DE, Hunter DJ, Dadaev, T, Bojesen, Stig E., Canzian, F, John, E M, Vincent, Daniel, Eeles, RA, Ostrander, E.A., Ross-Adams, Helen, Park JY, Park, JY, Saunders, EJ, Hamdy, F C, Dadaev, T., Baynes, C., Signorello, L B, Wilkinson, R A, Muir K, Bojesen, S E, Haiman CA, Saunders, E J, Baynes, Caroline, Dennis, J., Andriole G, Ross-Adams, H., Henderson, BE, Teixeira, M R, Baynes, C, Dennis J, Gronberg, Henrik, Sawyer EJ, Vincent, D., Campa, D, Saunders, E., Pharoah, Paul, Tessier, DC, Teixeira, M.R., Hunter, David J., Hunter, D J, Chanock, Stephen, Tymrakiewicz, M, Maier C, COGS CRUK GWAS ELLIPSE Initiative, Kaneva R, Travis, R C, Signorello, LB, Kote-Jarai, Z., Cybulski, Cezary, Baynes C, Donovan, J.L., Weischer, Maren, Park, J Y, Leongamornlert DA, Ostrander EA, Lubinski J, Luccarini, Craig, Dicks E, Cannon-Albright, L., Cannon-Albright, Lisa, Marchand, L L, Travis, Ruth C., Giles, GG, Ross-Adams, H, Pharoah, P., Giles, Graham, Kibel, Adam S., Kaneva, R, Neal DE, Khaw, Kay-Tee, Bacot, François, Haiman, CA, Teixeira, MR, Teixeira, Manuel R., Al Olama, AA, Giles, G G, Halim S, Key, TJ, Andriole, Gerald, Tessier, Daniel C., Benlloch, Sara, Conroy D, Hunter, DJ, Schumacher, F, Stanford JL, Schleutker, Johanna, Donovan, Jenny L., Brenner, H., Wiklund, F, Kraft, Peter, Brenner H, Al Olama, A A, Kaaks, Rudolf, Canzian F, Luccarini, C, Andriole, G, Clements, J., Canzian, Federico, Kaaks R, Conroy, D.K., Severi G, Park, J.Y., Severi, G, Signorello LB, Schleutker, J., Tymrakiewicz M, Cannon-Albright, L, Jugurnauth Little S, Bojesen, SE, Saunders EJ, Tessier, D.C., Riboli E, Spurdle, A, Bacot, F, Schaid D, Neal, D.E., Severi, Gianluca, Vincent, D, Henderson, Brian E., Vogel, Walther, Russel, Roslin, Ingles, S A, Albanes D, Khaw, K T, Batra J, Dunning AM, Gapstur S, Tessier, D C, Travis, RC, Morgan, Angela, PRACTICAL Consortium, Cybulski C, Weischer, M, Weischer M, Haiman, C A, Schaid, Dan, Conroy, D, Cannon Albright L, Bacot, F., Luccarini, C., Kote-Jarai, Zsofia, Sawyer, Emma J., Chanock, S, Maier, C, Teixeira MR, Chanock, S., UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, Gronberg, H., Vogel, W, Schumacher F, Kote-Jarai, Z, Brenner, H, Saunders, Edward J., Weischer, M., Govindasami, K., Wiklund F, Le Marchand, L., Kote Jarai Z, Benlloch S, Maier, Christiane, Guy, M, Easton, Douglas F., Amin Ali, A.L., Travis, R.C., Guy, M., Dadaev, Tokhir, Henderson, B.E., Tymrakiewicz, Malgorzata, Wiklund, Fredrik, Hayes, R.B., Govindasami K, Thibodeau, SN, Kibel, A S, UK ProtecT Study Collaborators, Clements, JA, Giles, G.G., Clements, J A, Thibodeau SN, Lubinski, J., Al Olama, Ali Amin, Kraft P, Russel, R., Jugurn-Little, S, Eeles, R A, Dunning, Alison M., Schaid, D, Stanford, J L, Berndt, SI, Chanock S, Eeles, R.A., Le Marchand, L, Leongamornlert, D A, Sawyer, E J, Andriole, G., Dicks, E., Easton, D.F., Giles GG, Pashayan, N., Hayes, Richard B., Lindstrom, Sara, Hamdy, Freddie, Kibel, A.S, Spurdle, Amanda, Morgan, A, Sawyer, EJ, Leongamornlert, Daniel A., Dicks, Ed, Morgan A, Brenner, Hermann, Gronberg H, Schumacher, F.R., Lindstrom S, Jugurnath-Little, S., Halim, S., Hayes, RB, Kaaks, R, Dunning, A M, Jugurnauth-Little, S, Eeles, Rosalind A., Halim, S, Berndt, S I +361 morecore +2 more sources
