Results 11 to 20 of about 28,516 (233)
Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation [PDF]
Biomedicines, 2023 Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse transcription of RNA template.
Anastasia I. Palamarchuk +2 more
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Telomerase reverse transcriptase and neurodegenerative diseases [PDF]
Frontiers in Immunology, 2023 Neurodegenerative diseases (NDs) are chronic conditions that result in progressive damage to the nervous system, including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic lateral sclerosis (ALS).
Xin Yu +5 more
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The regulations of telomerase reverse transcriptase (TERT) in cancer [PDF]
Cell Death and DiseaseAbnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu +7 more
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RNA Binding Domain of Telomerase Reverse Transcriptase [PDF]
Molecular and Cellular Biology, 2001 Telomerase is a ribonucleoprotein reverse transcriptase that extends the ends of chromosomes. The two telomerase subunits essential for catalysis in vitro are the telomerase reverse transcriptase (TERT) and the telomerase RNA.
Lai, Cary +2 more
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Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]
Jichu yixue yu linchuang, 2021 Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
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Bangabandhu Sheikh Mujib Medical University Journal, 2016 Retinol molecule was modified to predict the inhibitors of telomerase reverse transcriptase for the treatment of arsenical cancer through in silico study. Telomerase activity is expressed in the cancerous conditions which can be the target for anticancer
Kipchu Tshering, Mir Misbahuddin
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Functional Multimerization of the Human Telomerase Reverse Transcriptase [PDF]
Molecular and Cellular Biology, 2001 The telomerase enzyme exists as a large complex (;1,000 kDa) in mammals and at minimum is composed of the telomerase RNA and the catalytic subunit telomerase reverse transcriptase (TERT).
Tara L. Beattie +4 more
core +3 more sources
Telomerase Reverse Transcriptase Regulates microRNAs
International Journal of Molecular Sciences, 2015 MicroRNAs are small non-coding RNAs that inhibit the translation of target mRNAs. In humans, most microRNAs are transcribed by RNA polymerase II as long primary transcripts and processed by sequential cleavage of the two RNase III enzymes, DROSHA and ...
Mami Yasukawa +11 more
core +3 more sources
Human telomerase reverse transcriptase supports respiratory syncytial virus replication [PDF]
Communications BiologyRespiratory syncytial virus (RSV), discovered in 1956 and identified in children in 1957, is the major respiratory pathogen of infants and children under the age of 5 worldwide.
HoangDinh Huynh +2 more
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Reverse transcriptase motifs in the catalytic subunit of telomerase
Science, 1997 Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Telomerase RNA components have been identified from many organisms, but no protein component has been demonstrated to catalyze telomeric DNA ...
Cech, T. R. +5 more
core +4 more sources