RNA Binding Domain of Telomerase Reverse Transcriptase [PDF]
Molecular and Cellular Biology, 2001 Telomerase is a ribonucleoprotein reverse transcriptase that extends the ends of chromosomes. The two telomerase subunits essential for catalysis in vitro are the telomerase reverse transcriptase (TERT) and the telomerase RNA. Using truncations and site-specific mutations, we identified sequence elements of TERT and telomerase RNA required for ...
Lai, Cary +2 more
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Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase
Science, 1997 Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Telomerase RNA components have been identified from many organisms, but no protein component has been demonstrated to catalyze telomeric DNA extension.
Lingner, J. +5 more
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Functional Multimerization of the Human Telomerase Reverse Transcriptase [PDF]
Molecular and Cellular Biology, 2001 The telomerase enzyme exists as a large complex (approximately 1,000 kDa) in mammals and at minimum is composed of the telomerase RNA and the catalytic subunit telomerase reverse transcriptase (TERT). In Saccharomyces cerevisiae, telomerase appears to function as an interdependent dimer or multimer in vivo (J. Prescott and E. H.
T L, Beattie +3 more
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Functional identification and mapping of a gene that represses telomerase hTERT transcription in prostate cancer cells [PDF]
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomerase is present in over 90% of tumour tissues and immortalized cells and is tightly regulated in most normal somatic cells.
Hasan, Rana
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Expression of Telomerase Reverse Transcriptase in Adult Goldfish Retina
Journal of Molecular Neuroscience, 2007 Telomerase, a specialized reverse transcriptase that maintains telomere during cell division, is commonly associated with cell proliferation. Increasing evidence suggests that telomerase may bear functions other than telomere elongation. We investigated whether telomerase is expressed in the continuously growing goldfish retina.
Lau, BWM, So, KF, Tsao, GSW, Yip, HK
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The regulations of telomerase reverse transcriptase (TERT) in cancer
Cell Death and DiseaseAbnormal activation of telomerase occurs in most cancer types, which facilitates escaping from cell senescence. As the key component of telomerase, telomerase reverse transcriptase (TERT) is regulated by various regulation pathways. TERT gene changing in
Mingdi Liu +7 more
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The telomerase reverse transcriptase: components and regulation [PDF]
Genes & Development, 1998 The idea that chromosomes have special terminal structures first arose as a consequence of experiments conducted by Muller, who found that treatment of Drosophila with X-rays rarely resulted in terminal deletions or inversions of the chromosomes (Muller 1938).
C I, Nugent, V, Lundblad
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The role of the cell attachment in the regulation of telomerase during keratinocyte differentiation [PDF]
, 2010 PhDThe catalytic subunit of telomerase TERT has non-canonical functions, which are independent of telomere elongation and sometimes telomerase activity.
Cereser, Biancastella
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There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer [PDF]
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel +5 more
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The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression [PDF]
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation.
Newbold, RF, Kirkpatrick, KL, Mokbel, K
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