Results 11 to 20 of about 45,103 (233)

Diverse regulatory manners of human telomerase reverse transcriptase [PDF]

Cell Communication and Signaling, 2019
Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation,
Meng-Meng Jie, Xing Chang, Shuo Zeng, Cheng Liu, Guo-Bin Liao, Ya-Ran Wu, Chun-Hua Liu, Chang-Jiang Hu, Shi-Ming Yang, Xin-Zhe Li   +9 more
doaj   +3 more sources

Human telomerase reverse transcriptase expression in ovarian tumors

Indian Journal of Pathology and Microbiology, 2012
Background : Ovarian cancer is the 6 th most common cancer among women. In ovarian tumors, the borderline category is not well defined due to the difficulty in assessing stromal invasion. The World Health Organization (WHO) defined it as tumor that lacks
Awadh Ali Makhashen Maraei, Ahmad Zailani Hatta, Mohd Sidik Shiran, Geok Chin Tan   +3 more
doaj   +3 more sources

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Pleuroparenchymal fibroelastosis associated with telomerase reverse transcriptase mutations [PDF]

European Respiratory Journal, 2017
Five cases with telomerase reverse transcriptase mutation and pleuroparenchymal fibroelastosishttp://ow.ly ...
Hilario, Nunes, Florence, Jeny, Diane, Bouvry, Clément, Picard, Jean-François, Bernaudin, Christelle, Ménard, Pierre-Yves, Brillet, Caroline, Kannengiesser, Dominique, Valeyre, Marianne, Kambouchner   +9 more
openaire   +5 more sources

Structural basis of template-boundary definition in Tetrahymena telomerase. [PDF]

, 2015
Telomerase is required to maintain repetitive G-rich telomeric DNA sequences at chromosome ends. To do so, the telomerase reverse transcriptase (TERT) subunit reiteratively uses a small region of the integral telomerase RNA (TER) as a template.
Akiyama, Ben M, Jansson, Linnea I, Lu, Cheng, Ooms, Alexandra, Rubin, Seth M, Stone, Michael D   +5 more
core   +2 more sources

Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer

Balkan Medical Journal, 2017
Aims: To investigate the changes in mRNA expression levels of telomerase-related significant proteins in several types of cancer. Methods: Human telomerase reverse transcriptase, pontin, reptin and dyskerin expressions were measured in normal and tumour
Emel Çalışkan Can, M. Can Atalay, Ece Miser Salihoğlu, Ülkü Yalçıntaş Arslan, H. Bolkan Şimşek, Sevgi Yardım Akaydın   +5 more
doaj   +1 more source

RNA Binding Domain of Telomerase Reverse Transcriptase [PDF]

Molecular and Cellular Biology, 2001
Telomerase is a ribonucleoprotein reverse transcriptase that extends the ends of chromosomes. The two telomerase subunits essential for catalysis in vitro are the telomerase reverse transcriptase (TERT) and the telomerase RNA. Using truncations and site-specific mutations, we identified sequence elements of TERT and telomerase RNA required for ...
Lai, Cary, Mitchell, James R, Collins, Kathleen   +2 more
openaire   +3 more sources

Cancer-associated TERT promoter mutations abrogate telomerase silencing. [PDF]

, 2015
Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established.
Boyle, John, Chiba, Kunitoshi, Hockemeyer, Dirk, Johnson, Joshua, Vogan, Jacob, Wagner, Tina   +5 more
core   +1 more source

Telomerase Reverse Transcriptase Regulates microRNAs

International Journal of Molecular Sciences, 2015
MicroRNAs are small non-coding RNAs that inhibit the translation of target mRNAs. In humans, most microRNAs are transcribed by RNA polymerase II as long primary transcripts and processed by sequential cleavage of the two RNase III enzymes, DROSHA and DICER, into precursor and mature microRNAs, respectively.
Lassmann, Timo, Maida, Yoshiko, Tomaru, Yasuhiro, Yasukawa, Mami, Ando, Yoshinari, Kojima, Miki, Kasim, Vivi, Simon, Christophe, Daub, Carsten, Carninci, Piero, Hayashizaki, Yoshihide, Masutomi, Kenkichi   +11 more
openaire   +2 more sources

The telomerase reverse transcriptase: components and regulation [PDF]

Genes & Development, 1998
The idea that chromosomes have special terminal structures first arose as a consequence of experiments conducted by Muller, who found that treatment of Drosophila with X-rays rarely resulted in terminal deletions or inversions of the chromosomes (Muller 1938).
C I, Nugent, V, Lundblad
openaire   +2 more sources