Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer [PDF]
Journal of Biomedical Science, 2018 Background Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation.
Ricardo Leão +5 more
doaj +3 more sources
hTERT Promotes CRC Proliferation and Migration by Recruiting YBX1 to Increase NRF2 Expression
Frontiers in Cell and Developmental Biology, 2021 High human telomerase reverse transcriptase (hTERT) expression is related to severe Colorectal Cancer (CRC) progression and negatively related to CRC patient survival.
Huan Yang, Yu Huang, En Liu
exaly +3 more sources
HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. [PDF]
PLoS Pathogens, 2013 Previous studies have shown that wild-type human telomerase reverse transcriptase (hTERT) protein can functionally replace the human papillomavirus type 16 (HPV-16) E6 protein, which cooperates with the viral E7 protein in the immortalization of primary ...
Jonathan Miller +7 more
doaj +1 more source
Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction
Cell Reports, 2021 Summary: Human telomerase reverse transcriptase (hTERT) remains suppressed in most normal somatic cells. Resulting erosion of telomeres leads eventually to replicative senescence. Reactivation of hTERT maintains telomeres and triggers progression of >90%
Shalu Sharma +10 more
doaj +1 more source
AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase. [PDF]
PLoS ONE, 2018 The expression of hTERT in tumor cells contributes to oncogenic transformation by promoting immortalization. For this reason, hTERT is one of the major targets for cancer therapy, and an efficient method to downregulate hTERT expression is required for ...
Daum Jo +6 more
doaj +1 more source
International Journal of Hepatology, 2023 Background. The hTERT promoter mutation represents a common and early event in hepatocarcinogenesis, but its linkage to the morphological status of the underlying liver tissue is poorly understood. We analyzed the connection between the histopathological
Anne Kristin Fischer +5 more
doaj +1 more source
Molecular Oncology, 2021 Human telomerase reverse transcriptase (hTERT) plays an extremely important role in cancer initiation and development, including colorectal cancer (CRC). However, the precise upstream regulatory mechanisms of hTERT in different cancer types remain poorly
Chaoliang Diao +22 more
doaj +1 more source
Synthesis of Combretastatin A-4 and 3 0 -Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression [PDF]
, 2020 Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3 0 -aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities.
Agut, Raúl +7 more
core +1 more source
Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene. [PDF]
PLoS ONE, 2008 BACKGROUND: Lysine-specific demethylase 1 (LSD1), catalysing demethylation of mono- and di-methylated histone H3-K4 or K9, exhibits diverse transcriptional activities by mediating chromatin reconfiguration.
Qingjun Zhu +7 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2021 Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells.
Mariko Mizuguchi +5 more
doaj +1 more source