Results 31 to 40 of about 28,110 (249)
Biology Open, 2018 Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT expression and high ...
Ahmed El-Badawy +6 more
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FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer
Neoplasia: An International Journal for Oncology Research, 2023 Gastric cancer is one of most lethal diseases across the world. However, the underlying mechanism of gastric cancer carcinogenesis and development is still not fully known.
Qingyun Tang +7 more
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Diabetes, Metabolic Syndrome and Obesity, 2022 Jian Wang,1,2 Xiaodan Zhao,3 Guichang Tian,2 Xiaochao Liu,2 Chengyan Gui,2 Lin Xu1,4 1School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic of China; 2Department of Orthopedics, Qufu Hospital of TCM, Qufu,
Wang J +5 more
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Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]
Jichu yixue yu linchuang, 2021 Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
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Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias
Neoplasia: An International Journal for Oncology Research, 2014 Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells ...
Maroun Karam +14 more
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Molecular Oncology, 2020 Telomerase (hTERT) reactivation and sustained expression is a key event in the process of cellular transformation. Therefore, the identification of the mechanisms regulating hTERT expression is of great interest for the development of new anticancer ...
Delphine Garsuault +7 more
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An Improved Model for the hTERT Promoter Quadruplex
PLoS ONE, 2014 Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked ...
Jonathan B Chaires +6 more
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Investigating the Effects of RBBP6 Gene Expression on Telomerase Activity in Cervical Cancer Cells
Cancer Management and Research, 2020 Mpho Mosweu,1,* Lesetja Motadi,2,* Pontsho Moela1,* 1University of Pretoria, Faculty of Natural and Agricultural Sciences, Department of Biochemistry, Hatfield, Pretoria 0002, South Africa; 2University of Johannesburg, Faculty of Science, Department of ...
Mosweu M, Motadi L, Moela P
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Biomedicines, 2023 Background: Telomerase (human telomerase reverse transcriptase (hTERT) is considered a hallmark of cancer, being active in cancer cells but repressed in human somatic cells. As such, it has the potential to serve as a valid cancer biomarker.
Ofer Rotem +13 more
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The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation.
Newbold, RF, Kirkpatrick, KL, Mokbel, K
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