Results 31 to 40 of about 42,636 (233)
Biology Open, 2018 Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT expression and high ...
Ahmed El-Badawy +6 more
doaj +1 more source
Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]
Jichu yixue yu linchuang, 2021 Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
doaj
Diabetes, Metabolic Syndrome and Obesity, 2022 Jian Wang,1,2 Xiaodan Zhao,3 Guichang Tian,2 Xiaochao Liu,2 Chengyan Gui,2 Lin Xu1,4 1School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic of China; 2Department of Orthopedics, Qufu Hospital of TCM, Qufu,
Wang J +5 more
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Dynamic telomerase gene suppression via network effects of GSK3 inhibition. [PDF]
PLoS ONE, 2009 Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed.
Alan E Bilsland +10 more
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FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer
Neoplasia: An International Journal for Oncology Research, 2023 Gastric cancer is one of most lethal diseases across the world. However, the underlying mechanism of gastric cancer carcinogenesis and development is still not fully known.
Qingyun Tang +7 more
doaj +1 more source
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms [PDF]
, 2014 Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
A Agrawal +110 more
core +3 more sources
Antisense hTERT Inhibits Thyroid Cancer Cell Growth [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2003 Activation of telomerase represents an early step in carcinogenesis. Increased telomerase expression in malignant thyroid tumors suggests that inactivation of telomerase may represent a potential chemotherapeutic target. The purpose of this study was to inhibit the protein component of telomerase, hTERT, in a human thyroid cancer cell line in vitro and
Lisong, Teng +3 more
openaire +2 more sources
X-irradiation of cells on glass slides has a dose doubling impact [PDF]
, 2007 Immunofluorescence detection of γH2AX foci is a widely used tool to quantify the induction and repair of DNA double-strand breaks (DSBs) induced by ionising radiation.
Birch +23 more
core +1 more source
Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias
Neoplasia: An International Journal for Oncology Research, 2014 Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells ...
Maroun Karam +14 more
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Molecular Oncology, 2020 Telomerase (hTERT) reactivation and sustained expression is a key event in the process of cellular transformation. Therefore, the identification of the mechanisms regulating hTERT expression is of great interest for the development of new anticancer ...
Delphine Garsuault +7 more
doaj +1 more source