Results 41 to 50 of about 28,110 (249)

p53 and hTERT Determine Sensitivity to Viral Apoptosis [PDF]

Journal of Virology, 2007
ABSTRACTApoptosis is a potent host defense against microbes. Most viruses have adapted strategies to counteract this response. Herpes simplex virus (HSV) produces a balance between pro- and antiapoptotic processes during infection. When antiapoptotic signals become limiting, infected cells die through HSV-dependent apoptosis (HDAP).
Marie L, Nguyen, Rachel M, Kraft, Martine, Aubert, Edward, Goodwin, Daniel, DiMaio, John A, Blaho   +5 more
openaire   +2 more sources

Alternative splicing is a developmental switch for hTERT expression [PDF]

Molecular Cell, 2020
High telomerase activity is restricted to the blastocyst stage of embryonic development when telomere length is reset, and is characteristic of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). However, the pathways involved in telomerase regulation as a function of pluripotency remain unknown.
Penev, Alex, Bazley, Andrew, Shen, Michael, Boeke, Jef D., Savage, Sharon A., Sfeir, Agnel   +5 more
openaire   +2 more sources

hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer [PDF]

Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization.
Kefah Mokbel, Mitchell, B, حسینی اصل, سید سعید, Morteza Atri, Blake, JRS, Elkak, AE, Meligonis, G, مدرسی, محمد حسین, مهدی پور, پروین, Parvin Mehdipour, عطری, مرتضی, سلحاب, محمد, Salhab, M, Newbold, RF, مکبل, کفاه, Mokbel, K, Mohamed Salhab, Saied Hosseini-Asl, Mohammad H Modarressi   +18 more
core   +1 more source

Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro

Frontiers in Molecular Biosciences, 2021
Aptazyme and CRISPR/Cas gene editing system were widely used for regulating gene expression in various diseases, including cancer. This work aimed to reconstruct CRISPR/Cas13d tool for sensing hTERT exclusively based on the new device OFF-switch hTERT ...
Chengle Zhuang, Changshui Zhuang, Qun Zhou, Xueting Huang, Yaoting Gui, Yongqing Lai, Shangqi Yang   +6 more
doaj   +1 more source

Regulation of the human catalytic subunit of telomerase (hTERT) [PDF]

Gene, 2012
Over the past decade, there has been much interest in the regulation of telomerase, the enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in cellular immortalization, tumorigenesis, and the progression of cancer. Telomerase activity is characterized by the expression of the telomerase reverse transcriptase (TERT)
Michael, Daniel, Gregory W, Peek, Trygve O, Tollefsbol   +2 more
openaire   +2 more sources

hTERT Expression in Thyroid Nodule

Journal of the Korean Surgical Society, 2010
Purpose: Telomerase is expressed by most malignancies including thyroid cancer. In this study, to evaluate the telomerase activity, we determine the expression of human telomerase reverse transcriptase (hTERT) in benign and malignant thyroid tumors. Methods: We examined the clinical data such as age, sex, and recurrence status of 100 patients that ...
Tae-Won Kim, Chang-Hyeok An, Kee-Hwan Kim, Woo-Chan Park, Ja-Seong Bae, Jeong-Soo Kim   +5 more
openaire   +1 more source

There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer

, 2004
Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel, Newbold, RF, Katharine L Kirkpatrick, Kirkpatrick, KL, Mokbel, K, Robert F Newbold   +5 more
core   +1 more source

The use of hTERT-immortalized cells in tissue engineering [PDF]

Cytotechnology, 2004
The use of human telomerase reverse transcriptase (hTERT)-immortalized cells in tissue engineering protocols is a potentially important application of telomere biology. Several human cell types have been created that overexpress the hTERT gene with enhanced telomerase activity, extended life span and maintained or even improved functional activities ...
Kassem M, Abdallah BM, Yu Z, Ditzel N, Burns JS   +4 more
openaire   +3 more sources

hTERT-/low and hTERThigh PCa cell division modes from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERT^high Prostate Cancer Stem Cells

, 2017
hTERT-/low and hTERThigh PCa cell division modes from WNT/β-Catenin Directs Self-Renewal Symmetric Cell Division of hTERThigh Prostate Cancer Stem ...
Dawei Xu (83739), Yanjing Guo (720645), Xue Wang (102830), Wei-Qiang Gao (200112), Huifang Zhao (3341825), Zhongzhong Ji (5641541), Kai Zhang (102844), Chaping Cheng (5641544), Li Li (14993), Yuxiang Fang (14929871), Helen He Zhu (5641553)   +10 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source