Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation [PDF]
, 2016 Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful.
Bellomo, C +12 more
core +1 more source
Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells [PDF]
Carcinogenesis, 2008 Enhanced expression of human telomerase reverse transcriptase (hTERT) occurs frequently during cellular immortalization. The current study was undertaken to determine the mechanism regulating the hTERT promoter activity during cellular immortalization of human oral keratinocytes.
Reuben H, Kim +6 more
openaire +2 more sources
Biomedicines, 2023 Background: Telomerase (human telomerase reverse transcriptase (hTERT) is considered a hallmark of cancer, being active in cancer cells but repressed in human somatic cells. As such, it has the potential to serve as a valid cancer biomarker.
Ofer Rotem +13 more
doaj +1 more source
A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
core +2 more sources
European Journal of Medical Genetics, 2018 Regulation of telomerase activity is thought to participate in the cellular response to ionizing radiation. Epigenetic mechanisms play a role in this regulation, as well as other mechanisms such as transcription, phosphorylation, etc. Here, we investigated chromatin modifications in telomerase promoter upon exposure to ionizing radiation in human ...
Serakinci, Nedime +2 more
openaire +3 more sources
Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]
, 2018 The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea +4 more
core +1 more source
hTERT Expression in Thyroid Nodule
Journal of the Korean Surgical Society, 2010 Purpose: Telomerase is expressed by most malignancies including thyroid cancer. In this study, to evaluate the telomerase activity, we determine the expression of human telomerase reverse transcriptase (hTERT) in benign and malignant thyroid tumors. Methods: We examined the clinical data such as age, sex, and recurrence status of 100 patients that ...
Tae-Won Kim +5 more
openaire +1 more source
Investigating the Effects of RBBP6 Gene Expression on Telomerase Activity in Cervical Cancer Cells
Cancer Management and Research, 2020 Mpho Mosweu,1,* Lesetja Motadi,2,* Pontsho Moela1,* 1University of Pretoria, Faculty of Natural and Agricultural Sciences, Department of Biochemistry, Hatfield, Pretoria 0002, South Africa; 2University of Johannesburg, Faculty of Science, Department of ...
Mosweu M, Motadi L, Moela P
doaj
Frontiers in Molecular Biosciences, 2021 Aptazyme and CRISPR/Cas gene editing system were widely used for regulating gene expression in various diseases, including cancer. This work aimed to reconstruct CRISPR/Cas13d tool for sensing hTERT exclusively based on the new device OFF-switch hTERT ...
Chengle Zhuang +6 more
doaj +1 more source
Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells [PDF]
, 2016 open7siBesides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions.
Celeghin, Andrea +6 more
core +1 more source