Results 51 to 60 of about 28,110 (249)

Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma Cells

Cells, 2023
Pleural mesothelioma (PM) is an aggressive malignancy that develops in a unique tumor microenvironment (TME). However, cell models for studying the TME in PM are still limited.
Alexander Ries, Astrid Slany, Christine Pirker, Johanna C. Mader, Doris Mejri, Thomas Mohr, Karin Schelch, Daniela Flehberger, Nadine Maach, Muhammad Hashim, Mir Alireza Hoda, Balazs Dome, Georg Krupitza, Walter Berger, Christopher Gerner, Klaus Holzmann, Michael Grusch   +16 more
doaj   +1 more source

Chromatin modifications of hTERT gene in hTERT-immortalized human mesenchymal stem cells upon exposure to radiation

European Journal of Medical Genetics, 2018
Regulation of telomerase activity is thought to participate in the cellular response to ionizing radiation. Epigenetic mechanisms play a role in this regulation, as well as other mechanisms such as transcription, phosphorylation, etc. Here, we investigated chromatin modifications in telomerase promoter upon exposure to ionizing radiation in human ...
Serakinci, Nedime, Tiber, Pinar Mega, Orun, Oya   +2 more
openaire   +4 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Human telomerase reverse transcriptase promotes the epithelial to mesenchymal transition in lung cancer cells by enhancing c-MET upregulation

Heliyon, 2022
Human telomerase reverse transcriptase (hTERT), the essential catalytic subunit of telomerase, is associated with telomere homeostasis to prevent replicative senescence and cellular aging.
Ram Raj Prasad, Deepak Kumar Mishra, Manoj Kumar, Pramod Kumar Yadava   +3 more
doaj   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Diagnostic value of methylated human telomerase reverse transcriptase (hTERT) in human cancers: a meta-analysis

Frontiers in Oncology, 2015
Human telomerase reverse transcriptase (hTERT) plays a critical role in the pathogenesis of human malignancies. Overexpression of hTERT is essential in controlling the propagation of cancer cells.
Wei eGao, Yuan eShi, Wei eLiu, Wei-Yin eLin, Chia-Ching (Josh) eWu, Jimmy Yu-Wai eChan, Thian-Sze eWong   +6 more
doaj   +1 more source

Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth

, 2006
Telomerase catalytic subunit (TERT) seems a key factor controlling telomerase activity, telomere length, and cell growth. To further address this issue, we forced expression of a catalytically inactive mutant human TERT (hTERT) in hTERT-immortalised ...
Cui, Wei, Mo, Ling, Rahman, Ruman
core   +1 more source

Ein photoschaltbares Vitamin‐D‐Mimetikum mit agonistischer und antagonistischer Aktivität ermöglicht bidirektionale optische Kontrolle von VDR

Angewandte Chemie, EarlyView.
Vitamin D entfaltet über die Aktivierung des ligandenabhängigen Transkriptionsfaktors Vitamin‐D‐Rezeptor (VDR) komplexe und zellspezifische biologische Wirkungen in verschiedenen Geweben. Das photoschaltbare Vitamin‐D‐Mimetikum 10 wechselt durch Belichtung zwischen VDR‐Antagonisten‐ (E) und Agonisten‐Aktivität (Z) und bietet eine bislang einzigartige ...
Xiu Ge, Sabine Willems, Francesco Melfi, Tufan Mukhopadhyay, Johannes Morstein, Jordan Artzy, Loris Knümann, Giorgia Sbriccoli, Jörg Pabel, Julian A. Marschner, Dirk Trauner, Daniel Merk   +11 more
wiley   +1 more source

An Agonist/Antagonist Photo‐Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR

Angewandte Chemie International Edition, EarlyView.
Vitamin D exhibits complex and cell‐specific biological effects in multiple tissues via activation of the ligand‐sensing transcription factor vitamin D receptor (VDR). The photo‐switchable vitamin D mimetic 10 transitions between VDR antagonist (E) and agonist (Z) activity upon illumination and offers unprecedented bidirectional optical control over ...
Xiu Ge, Sabine Willems, Francesco Melfi, Tufan Mukhopadhyay, Johannes Morstein, Jordan Artzy, Loris Knümann, Giorgia Sbriccoli, Jörg Pabel, Julian A. Marschner, Dirk Trauner, Daniel Merk   +11 more
wiley   +1 more source

hTERT wt and hTERT-D868A do not activate the hTERT promoter.

, 2013
Keratinocytes were transfected with either wt hTERT core promoter or the cyclin D1 promoter and either HPV16E6, hTERT wt, or hTERT-D8686A. The pRL-CMV R.
Jonathan Miller (79680), Nancy Palechor-Ceron (399059), Richard Schlegel (4309), Aleksandra Dakic (399057), Bhaskar Kallakury (197766), Yuhai Dai (399060), Xuefeng Liu (130787), Renxiang Chen (399058)   +7 more
core   +1 more source