Results 51 to 60 of about 42,636 (233)

AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model [PDF]

, 2016
Limitless replicative potential is one of the hallmarks of cancer that is mainly due to the activity of telomerase. This holoenzyme maintains telomere length, adding TTAGGG repetitions at the end of chromosomes in each cell division.
Armando, Romina Gabriela, Gomez, Daniel Eduardo, Gomez, Daniel Eduardo   +2 more
core   +1 more source

Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma Cells

Cells, 2023
Pleural mesothelioma (PM) is an aggressive malignancy that develops in a unique tumor microenvironment (TME). However, cell models for studying the TME in PM are still limited.
Alexander Ries, Astrid Slany, Christine Pirker, Johanna C. Mader, Doris Mejri, Thomas Mohr, Karin Schelch, Daniela Flehberger, Nadine Maach, Muhammad Hashim, Mir Alireza Hoda, Balazs Dome, Georg Krupitza, Walter Berger, Christopher Gerner, Klaus Holzmann, Michael Grusch   +16 more
doaj   +1 more source

The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients [PDF]

, 2018
Background: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable.
A Celeghin, A Habr-Gama, AL Appelt, Alessandro Perin, AM Mandard, Angela Buonadonna, Anita De Rossi, Antonino De Paoli, C Alix-Panabières, C Belluco, Caterina Boso, Claudio Belluco, D Beddy, D Hanahan, D Lin, D Tural, E Rampazzo, E Rampazzo, E Rampazzo, EH Blackburn, Elisa Palazzari, Enrica Rampazzo, Francesca Bergamo, G Saretzki, G Spolverato, Giovanna Spiro, I Gingras, J Buijsen, J Maláska, JA March-Villalba, JF Bosset, JM Lewis, JP Gerard, K Bujko, K Kojima, L Moureau-Zabotto, L Terrin, L Terrin, LA Torre, M Maas, M Spornraft, MB Amin, MS Roh, N Miura, N Tani, P Boscolo-Rizzo, Paola Del Bianco, R Bertorelle, R Bertorelle, R Sauer, R Siegel, RK Deblakshmi, Roberta Bertorelle, S Giunco, S Pucciarelli, S Pucciarelli, Salvatore Pucciarelli, Sara Leonardi, SB Edge, SH Lim, SM Lledó, T El-Hefnawy, Y Kang   +62 more
core   +1 more source

Targeting apoptosis to cancer via hTERT promoter [PDF]

Cancer Biology & Therapy, 2006
Commentary to:hTERT/re-Caspase-3 System Induce Apoptosis in hTERT-Positive Cancer CellsLi-fang Yang, Yan Zhao, Liang Zeng, Jian-ping Gong, and Ya ...
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Diagnostic value of methylated human telomerase reverse transcriptase (hTERT) in human cancers: a meta-analysis

Frontiers in Oncology, 2015
Human telomerase reverse transcriptase (hTERT) plays a critical role in the pathogenesis of human malignancies. Overexpression of hTERT is essential in controlling the propagation of cancer cells.
Wei eGao, Yuan eShi, Wei eLiu, Wei-Yin eLin, Chia-Ching (Josh) eWu, Jimmy Yu-Wai eChan, Thian-Sze eWong   +6 more
doaj   +1 more source

Human telomerase reverse transcriptase promotes the epithelial to mesenchymal transition in lung cancer cells by enhancing c-MET upregulation

Heliyon, 2022
Human telomerase reverse transcriptase (hTERT), the essential catalytic subunit of telomerase, is associated with telomere homeostasis to prevent replicative senescence and cellular aging.
Ram Raj Prasad, Deepak Kumar Mishra, Manoj Kumar, Pramod Kumar Yadava   +3 more
doaj   +1 more source

Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. [PDF]

, 2015
Gene knockout strategies, RNAi and rescue experiments are all employed to study mammalian gene function. However, the disadvantages of these approaches include: loss of function adaptation, reduced viability and gene overexpression that rarely matches ...
Dowdy, Steven F, Kaulich, Manuel, Lee, Yeon J, Lönn, Peter, Meade, Bryan R, Springer, Aaron D   +5 more
core   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

BMC Cancer, 2010
Background Activation of telomerase resulting from deregulated hTERT expression is a key event during high-risk human papillomavirus (hrHPV)-induced cervical carcinogenesis. In the present study we examined hTERT promoter activity and its relation to DNA
Snijders Peter JF, Meijer Chris JLM, Claassen-Kramer Debbie, Overmeer Renée M, Kooter Jan M, de Wilde Jillian, Steenbergen Renske DM   +6 more
doaj   +1 more source