Results 71 to 80 of about 28,110 (249)

hTERT interacts with UBE2D3 proteins.

, 2013
(A)pEGFP-hTERT and pdsRed-UBE2D3 were co-transfected into MCF-7 cells. UBE2D3 with red fluorescent tag(A-a), hTERT with green fluorescent tag(A-b). The 3rd pic is the merge(A-c).
Wenbo Wang (300277), Haijun Yu (417023), Yunfeng Zhou (417027), Zhengkai Liao (417025), Liu Hu (417021), Ling Xia (43628), Han Lei (417024), Lei Yang (102719), Fuxiang Zhou (417026), Li Ren (417022), Fen Li (337013), Yu Liu (6938), Conghua Xie (282964)   +12 more
core   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Effects of siRNAs on hTERT.

, 2014
A1: analysis of hTERT protein expression by western blot. A2: Quantitative analysis of western blot (A1). B: analysis of hTERT mRNA expression by real-time PCR.
Zijian Xiao (591185), Weiwei Qi (591190), Jianwen Lin (591187), Aiwu Zhang (591186), Zhenyang Zheng (591188), Wei Di (591189), Yannan Fang (591193), Xiaolei Shi (319891), Guijuan Zhou (591192), Yingting Zhu (591191)   +9 more
core   +1 more source

Expression of telomerase (hTERT) in aldosterone-producing adrenocortical tumors [PDF]

, 2006
Telomerase was found in cancers and immortalized cell lines, but only occasionally in normal tissues, thus suggesting that measurement of its hTERT subunit might help distinguishing benign from malignant tumors. Data on hTERT expression in adrenocortical
BELLONI A, PESSINA A. C., FASSINA, AMBROGIO, STICCHI D, ROSSI, GIANPAOLO   +4 more
core   +1 more source

D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose D‐amino acid oxidase (DAO) has been developed as a chemogenetic tool, to precisely manipulate redox levels in tissues and cells by generating H2O2 in the presence of D‐amino acids. The enzyme's significant oxygen consumption during H2O2 production may influence cellular oxygen levels.
Wiebke Maurer, Anke Zieseniss, Vamsi Priya Vikram, Yamin Chen, Laura Bauer, Annette Hillemann, Peter Rehling, Maithily S. Nanadikar, Diane de Zélicourt, Vartan Kurtcuoglu, Dörthe M. Katschinski   +10 more
wiley   +1 more source

Alternative Splicing of Human Telomerase Reverse Transcriptase May Not Be Involved in Telomerase Regulation During all-trans-Retinoic Acid-Induced HL-60 Cell Differentiation

Journal of Pharmacological Sciences, 2004
Alternative splicing of the human telomerase reverse transcriptase subunit (hTERT) suppresses telomerase activity during the development of human fetal kidney cells into mature cells.
Wei-Jun Liu, Yong-Wei Zhang, Zhi-Xiang Zhang, Jian Ding   +3 more
doaj   +1 more source

Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF receptors. [PDF]

PLoS ONE, 2017
Targeting angiogenesis has been considered a promising treatment of choice for a large number of malignancies, including gastrointestinal cancers. Bevacizumab is an anti-vascular endothelial growth factor (anti-VEGF) being used for this purpose. However,
Nadine Mahfouz, Roula Tahtouh, Nada Alaaeddine, Joelle El Hajj, Riad Sarkis, Ray Hachem, Issam Raad, George Hilal   +7 more
doaj   +1 more source

Decreased Fas-induced apoptosis in hTERT⁺ vs. hTERT^ctrl transfected MLE cells.

, 2015
MLE cells were transfected with hTERT or control expression vector, and exposed to Fas or control IgG mAb (10 μg/ml, 24h). (A) Histogram plot and (B) confocal microscopy of Annexin V staining (blue) and PI (red) in hTERT+ vs.
Pazit Y. Cohen (243147), Mark Richter Dayan (736267), Regina Golan-Gerstl (736265), Raphael Breuer (736269), Nissim Arish (736264), Shulamit B. Wallach-Dayan (736270), Philip Zisman (736268), Zvi Fridlender (736266)   +7 more
core   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

hTERT Expression in Cell Lines.

, 2013
Top image shows hTERT expression detected at 200 bp in a Werner syndrome cell line (positive control) immortalised for hTERT (Lane1). hTERT expression is also detected in the bladder cancer cell lines RT112 and RT4 (Lanes 2 and 3 respectively).
Stephanie R. McKeown (300188), Declan J. McKenna (300183), Bernadette A. Doherty (300185), C. Stephen Downes (300187), Valerie J. McKelvey-Martin (300189)   +4 more
core   +1 more source