Results 71 to 80 of about 42,636 (233)

Inducible immortality in hTERT‐human mesenchymal stem cells [PDF]

Journal of Orthopaedic Research, 2012
AbstractHuman mesenchymal stem cells (hMSCs) are attractive candidates for tissue engineering and cell‐based therapy because of their multipotentiality and availability in adult donors. However, in vitro expansion and differentiation of these cells is limited by replicative senescence.
Samantha L, Piper, Miqi, Wang, Akira, Yamamoto, Farbod, Malek, Andrew, Luu, Alfred C, Kuo, Hubert T, Kim   +6 more
openaire   +2 more sources

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Human Telomerase Reverse Transcriptase (hTERT) expression in patients with Chronic Myelogenous Leukemia at defferent phases of the disease

پیاورد سلامت, 2008
Background and Aim: Chronic Myelogenous Leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by a translocation between chromosome 9 and 22 called Philadelphia Chromosome. Telomerase- essential enzyme that adds telomeric repeats into
A Amini, SH Ghaffari, Y Mortazavi, N Eynolahi, K Alimoghadam, Sh Rostami, Y Gahani, A Ghavamzadeh   +7 more
doaj  

Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461

Journal of Experimental & Clinical Cancer Research, 2018
Background Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers.
Guihong Li, Jing Shen, Junguo Cao, Guangtong Zhou, Ting Lei, Yuxue Sun, Haijun Gao, Yaonan Ding, Weidong Xu, Zhixin Zhan, Yong Chen, Haiyan Huang   +11 more
doaj   +1 more source

The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. [PDF]

, 2019
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood.
Ananthapadmanabhan, Varsha, Dozmorov, Mikhail, Felthousen, Jessica, Guiley, Keelan Z, Iness, Audra N, Litovchick, Larisa, Rubin, Seth M, Saini, Siddharth, Sesay, Fatmata   +8 more
core  

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin [PDF]

, 2014
Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs).
Alex D. Herbert, Amani Ismail, Andreas Kakarougkas, Anna L. Chambers, Brownlee, Campbell, Cao, Chambers, Chou, Enriqueta Riballo, Fradet-Turcotte, Francia, Ginjala, Goodarzi, Jessica A. Downs, Julia Künzel, Khavari, Lin, Markus Löbrich, Mathas, Matsuoka, Mattiroli, Mosesso, Noon, Oum, Papamichos-Chronakis, Penny A. Jeggo, Rulten, Schaaf, Shain, Shanbhag, Shema-Yaacoby, Shibata, Stiff, Varela, Vissers, Wei   +36 more
core   +1 more source

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, EarlyView.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. [PDF]

, 2018
The successful implementation of miRNA (miR) therapies in humans will ultimately rely on the use of vehicles with improved cellular delivery capability. Here we tested a new system that leverages extracellular vesicles (EVs) laden with a tumor suppressor
Almanza, Gonzalo, Carter, Hannah, Jepsen, Kristen, Rodvold, Jeffrey J, Tsui, Brian, Zanetti, Maurizio   +5 more
core   +2 more sources

An Agonist/Antagonist Photo‐Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR

Angewandte Chemie International Edition, EarlyView.
Vitamin D exhibits complex and cell‐specific biological effects in multiple tissues via activation of the ligand‐sensing transcription factor vitamin D receptor (VDR). The photo‐switchable vitamin D mimetic 10 transitions between VDR antagonist (E) and agonist (Z) activity upon illumination and offers unprecedented bidirectional optical control over ...
Xiu Ge, Sabine Willems, Francesco Melfi, Tufan Mukhopadhyay, Johannes Morstein, Jordan Artzy, Loris Knümann, Giorgia Sbriccoli, Jörg Pabel, Julian A. Marschner, Dirk Trauner, Daniel Merk   +11 more
wiley   +1 more source

Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF receptors. [PDF]

PLoS ONE, 2017
Targeting angiogenesis has been considered a promising treatment of choice for a large number of malignancies, including gastrointestinal cancers. Bevacizumab is an anti-vascular endothelial growth factor (anti-VEGF) being used for this purpose. However,
Nadine Mahfouz, Roula Tahtouh, Nada Alaaeddine, Joelle El Hajj, Riad Sarkis, Ray Hachem, Issam Raad, George Hilal   +7 more
doaj   +1 more source