Results 91 to 100 of about 28,110 (249)
hTERT-shRNA inhibits hTERT expression and telomerase activity in vitro.
, 2014 (A) RT-PCR analysis of hTERT mRNA expression in SW480 cultures after mock-transfection with culture medium alone (Blank), Lipofectamine alone (Lipo), negative control siRNA (NC-shRNA), or hTERT-shRNA.
Xiao-Ling Luo (627996) +6 more
core +1 more source
Clinicopathological Significance of hTERT gene expression in Breast Cancer Patients
, 2022 Amaç: Bu çalışma, meme kanserinde insan telomeraz ters transkriptaz (hTERT) genin mRNA ekspresyonunun klinik önemini incelemeyi ve klinikopatolojik rolünü araştırmayı amaçlamıştır.
Kankaya, Burak +5 more
core +1 more source
Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications
WIREs RNA, Volume 17, Issue 4, July/August 2026.Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus +5 more
wiley +1 more source
Scientific Reports, 2017 Most cancer cells have telomerase activity because they can express the human telomerase reverse transcriptase (hTERT) gene. Therefore, the inhibition of the hTERT expression can play an important role in controlling cancer cell proliferation.
Pankaj Attri +9 more
doaj +1 more source
FLIP is upregulated in hTERT+ vs. hTERTctrl transfected MLE cells.
, 2015 (A) Flow cytometry dot plots of FLIP expression, and (B) Western blot using anti-FLIP mAb in hTERT+ vs. hTERTctrl (control) transfected cells. OD ratios showing increased FLIP in hTERT+ mouse lung MLE epithelial transfected cells are presented ...
Pazit Y. Cohen (243147) +7 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.We describe a microfluidic tumor‐stroma co‐culture model, engineered to resist collagen‐hydrogel contraction driven by fibroblast activity. Surface silanization with APTES covalently anchors the matrix to the chip, while Genipin crosslinking progressively increases stiffness and elasticity without harming cells. This supports >10 days of co‐culture and
Doriane Le Manach +4 more
wiley +1 more source
Decreased bleomycin-induced apoptosis in hTERT transfected MLE cells.
, 2015 (A) PCR-based telomerase activity in Mouse-Lung Epithelial (MLE) cells transfected with hTERT+ or control hTERT (hTERTctrl) expression vectors. hTERT+ and hTERTctrl MLE cells were exposed to bleomycin (0.06mU) or control saline.
Pazit Y. Cohen (243147) +7 more
core +1 more source
A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat
Advanced Science, Volume 13, Issue 31, 4 June 2026.An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su +10 more
wiley +1 more source
Diverse regulatory manners of human telomerase reverse transcriptase
Cell Communication and Signaling, 2019 Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation,
Meng-Meng Jie +9 more
doaj +1 more source
Phenotypic characterization of hTERT-immortalized mADSCs.
, 2016 Primary mADSCs were infected with a retroviral vector harboring hTERT-IRES-EGFP, and selected for about 3 months with puromycin. (A) Morphology of hTERT-immortalized mADSCs.
Jong-Ho Kim (317877) +7 more
core +1 more source