Results 91 to 100 of about 23,862 (194)

TRIM28 Increases RFC4 Protein Expression to Promote Triple‐Negative Breast Cancer Progression

MedComm, Volume 7, Issue 10, October 2026.
RFC4 dysregulation has been implicated in tumor progression and poor prognosis across multiple cancer types. Triple‐negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options and unfavorable clinical outcomes, highlighting the need to identify effective therapeutic targets.
Cheng Guo, Li Liu, Lixiang Sun, Litong Liu, Han Wei, Yutong Yan, Fei Yu, Guangming Fu, Xianning Dong, Ceshi Chen, Chengqin Wang   +10 more
wiley   +1 more source

hTERT/re-caspase-3 system induce apoptosis in hTERT-positive cancer cells.

Cancer biology & therapy, 2007
Apoptosis induction is a promising approach for the treatment of human cancer. To achieve this purpose, the design of an expression system capable to induce apoptosis specifically in cancer cells is essential. Telomerase is an attractive target for delivery of apoptotic genes as an overwhelming majority of cancers have telomerase activity whereas most ...
Li-fang, Yang, Yan, Zhao, Liang, Zeng, Jian-ping, Gong, Ya, Cao   +4 more
openaire   +1 more source

On the road to immortality: hTERT upregulation in cancer cells [PDF]

FEBS Letters, 2004
Telomere attrition limits the replicative potential of most somatic cells. In contrast, tumor cells acquire immortality by continuous telomere maintenance which is predominantly due to the transcriptional upregulation of the limiting component of telomerase, hTERT (human telomerase reverse transcriptase).
openaire   +2 more sources

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 10, Page 1626-1647, October 2026.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

hTERT/re-caspase-3 system induce apoptosis in hTERT-positive [PDF]

Cancer Biology & Therapy, 2006
Li-fang Yang, Yan Zhao, Liang Zeng, Jian-ping Gong, Ya Cao   +4 more
openaire   +1 more source

IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF MICRORNAS REGULATING HTERT

Experimental Oncology
Background. Telomerase is a ribonucleoprotein (RNP) reverse transcriptase that replicates the ends of chromosomes, thereby maintaining genome integrity, and its inhibition may be envisioned to prevent carcinogenesis or treat cancer patients. Various approaches have been used to target hTERT, and one of the promising strategies is the use of hTERT ...
Maham, Ansari, Rafiullah, Rafiullah, Abdul, Wali, Afrasiab Khan, Tareen, Imrana Niaz, Sultan, Muhammad Mushtaq, Yasinzai   +5 more
openaire   +2 more sources

Development of 3D Cell-Based Fluorescent Reporter Assay for Screening of Drugs Downregulating Telomerase Reverse Transcriptase

Bioengineering
A fluorescent cell-based assay was developed for the screening of chemicals repressing the expression of human telomerase reverse transcriptase (hTERT).
You Li, Fengli Zhang, Zhen Qin, Shang-Tian Yang   +3 more
doaj   +1 more source

Acute Exercise Regulates Htert Alternative Splicing In Contractile Tissues Of Htert-bac Mice

Medicine & Science in Sports & Exercise, 2021
Aaron L. Slusher, Andrew T. Ludlow
openaire   +2 more sources

Study of hTERT and Histone 3 Mutations in Medulloblastoma.

Pathobiology : journal of immunopathology, molecular and cellular biology, 2017
Hotspot activating mutations of the telomerase reverse transcriptase (hTERT) promoter region were recently described in several tumor types. These mutations lead to enhanced expression of telomerase, being responsible for telomere maintenance and allowing continuous cell division.
Viana-Pereira, Marta, Almeida, Gisele Caravina, Stávale, João Norberto UNIFESP, Malheiro, Susana UNIFESP, Clara, Carlos, Lobo, Patricia, Pimentel, Jose, Reis, Rui Manuel   +7 more
openaire   +3 more sources

TELOMERASE CATALYTIC SUBUNIT mRNA IN LARYNGEAL SQUAMOUS CELL CARCINOMAS

Zdravniški Vestnik, 2002
Background. Re-activation of the enzyme telomerase, has been detected in nearly 90% of human malignancies. In contrast, normal human somatic cells, with the exception of germ cells and stem cells of renewable tissues, do not have detectable telomerase ...
Boštjan Luzar, Mario Poljak, Irena J. Marin, Janez Fischinger, Nina Gale   +4 more
doaj