Results 111 to 120 of about 42,636 (233)
Telomere Length, Proviral Load and Neurologic Impairment in HTLV-1 and HTLV-2-Infected Subjects. [PDF]
, 2016 Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of ...
Blackburn, Elizabeth +5 more
core +3 more sources
Molecular Oncology, Volume 20, Issue 5, Page 1253-1269, May 2026.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background Human telomerase reverse transcriptase (hTERT) is highly expressed in over 80% of tumors, including human epithelial ovarian cancer (EOC). However, the mechanisms through which hTERT is up-regulated in EOC and promotes tumor progression remain
Yong-Bin Liu +5 more
doaj +1 more source
Gene-specific methylation profiles in BRCA-mutation positive and BRCA-mutation negative male breast cancers [PDF]
, 2018 Male breast cancer (MBC) is a rare disease. Due to its rarity, MBC research and clinical approach are mostly based upon data derived from female breast cancer (FBC). Increasing evidence indicate that on molecular level MBC may be an heterogeneous disease
Bianchi, Simonetta +8 more
core +2 more sources
An Improved Model for the hTERT Promoter Quadruplex
PLoS ONE, 2014 Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked ...
Jonathan B Chaires +6 more
openaire +4 more sources
Advanced Science, Volume 13, Issue 26, 8 May 2026.The spatiotemporal dynamics of protein kinase diffusion govern cellular signaling and functions. Although vital for active receptors, the role of pseudokinase dynamics is unclear. Here, we use single‐molecule tracking to link faster diffusion of pseudokinase PTK7 to increased tumor cell invasion and migration.
Yaohua Li +8 more
wiley +1 more source
The World Journal of Men's HealthPurpose: Castration-resistant prostate cancer (CRPC) presents a significant clinical challenge, particularly when it metastasizes to bone, leading to skeletal-related events such as osteolysis.
Da Hyun Yun +5 more
doaj +1 more source
Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells [PDF]
, 2017 Human telomerase reverse transcriptase (hTERT) is expressed in most cancer cells. Paradoxically, its promoter is embedded in a hypermethylated CpG island. A short region escapes to this alteration, allowing a basal level of transcription.
Benhattar, Jean +5 more
core
hTERT/re-caspase-3 system induce apoptosis in hTERT-positive [PDF]
Cancer Biology & Therapy, 2006 Li-fang Yang +4 more
openaire +1 more source
Advanced Science, Volume 13, Issue 26, 8 May 2026.ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy +8 more
wiley +1 more source