Results 111 to 120 of about 28,110 (249)

hTERT expression in immortalized esophageal myofibroblasts.

, 2016
Primary esophageal myofibroblasts transfected with human telomerase (hTERT) express elevated hTERT transcript levels as determined by quantitative RT-PCR.
Matthew Gargus (2602231), Anisa Shaker (2602234), Uday Chauhan (2602237), Chao Niu (398203)   +3 more
core   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

hTERT/re-caspase-3 system induce apoptosis in hTERT-positive cancer cells.

Cancer biology & therapy, 2007
Apoptosis induction is a promising approach for the treatment of human cancer. To achieve this purpose, the design of an expression system capable to induce apoptosis specifically in cancer cells is essential. Telomerase is an attractive target for delivery of apoptotic genes as an overwhelming majority of cancers have telomerase activity whereas most ...
Li-fang, Yang, Yan, Zhao, Liang, Zeng, Jian-ping, Gong, Ya, Cao   +4 more
openaire   +1 more source

Telomere length and hTERT in mania and subsequent remission [PDF]

Revista Brasileira de Psiquiatria, 2017
The findings of telomere length (TL) studies in bipolar disorder (BD) are controversial. The aim of the present study was to detect TL, human telomerase reverse transcriptase (hTERT), and brain derived neurotrophic factor (BDNF) in severe mania and subsequent remission.Twenty-one medication-free male patients and 20 age and gender matched controls were
openaire   +6 more sources

Transient expression of AMPKα1 rescues hTERT expression.

, 2018
(A) Transient expression of AMPKα1 rescues hTERT-Luc activity. Control cells and AMPKα1 KO cells were transfected with hTERT-Luc plasmid with either empty vector or plasmid encoding AMPK.
Minsu Jang (2817730), Ik-Soon Jang (147206), Daum Jo (6009578), Junsoo Park (147202), Rackhyun Park (735914), Eun-Ju Lee (2670493), Hyunju Kim (124616)   +6 more
core   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Targeting apoptosis to cancer via hTERT promoter [PDF]

Cancer Biology & Therapy, 2006
Commentary to:hTERT/re-Caspase-3 System Induce Apoptosis in hTERT-Positive Cancer CellsLi-fang Yang, Yan Zhao, Liang Zeng, Jian-ping Gong, and Ya ...
openaire   +2 more sources

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

RIF1 promotes human epithelial ovarian cancer growth and progression via activating human telomerase reverse transcriptase expression

Journal of Experimental & Clinical Cancer Research, 2018
Background Human telomerase reverse transcriptase (hTERT) is highly expressed in over 80% of tumors, including human epithelial ovarian cancer (EOC). However, the mechanisms through which hTERT is up-regulated in EOC and promotes tumor progression remain
Yong-Bin Liu, Ying Mei, Jing Long, Yu Zhang, Dong-Li Hu, Hong-Hao Zhou   +5 more
doaj   +1 more source

Exosomal miR‐4644 Targets SPRY3 to Promote Proliferation and Invasion of Pancreatic Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Tumor‐derived exosomes (TDEs) can carry diverse genetic material that modulates pancreatic cancer (PC) proliferation and invasion. Despite this, the involvement of microRNAs (miRNAs) in TDE‐mediated tumor progression in PC remains inadequately explored. Methods Ultracentrifugation was used to isolate exosomes derived from AsPC‐1 and
Xiangyu Chu, Dongqi Li, Fusheng Zhang, Yongsu Ma, Yongqi Deng, Chen Wang, Xiaodong Tian, Yanlian Yang, Yinmo Yang   +8 more
wiley   +1 more source