Results 121 to 130 of about 28,110 (249)
The World Journal of Men's HealthPurpose: Castration-resistant prostate cancer (CRPC) presents a significant clinical challenge, particularly when it metastasizes to bone, leading to skeletal-related events such as osteolysis.
Da Hyun Yun +5 more
doaj +1 more source
On the road to immortality: hTERT upregulation in cancer cells [PDF]
FEBS Letters, 2004 Telomere attrition limits the replicative potential of most somatic cells. In contrast, tumor cells acquire immortality by continuous telomere maintenance which is predominantly due to the transcriptional upregulation of the limiting component of telomerase, hTERT (human telomerase reverse transcriptase).
openaire +2 more sources
The role of the cell attachment in the regulation of telomerase during keratinocyte differentiation
, 2010 PhDThe catalytic subunit of telomerase TERT has non-canonical functions, which are independent of telomere elongation and sometimes telomerase activity.
Cereser, Biancastella
core
Inducible CRISPR/Cas systems in precision oncology: Current applications and future perspectives
Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.Inducible CRISPR/Cas systems enable spatiotemporal genome editing in precision oncology. Chemical, optical, physical, and microenvironmental stimuli provide distinct control strategies. Conditional activation may reduce off‐target exposure and basal nuclease activity.
Ziliang Ding +3 more
wiley +1 more source
hTERT/re-caspase-3 system induce apoptosis in hTERT-positive [PDF]
Cancer Biology & Therapy, 2006 Li-fang Yang +4 more
openaire +1 more source
BMC Cancer, 2017 Background The study was aimed to quantitatively detect mRNA levels of the catalytic subunit of telomerase (hTERT) in both peripheral blood and circulating tumor cells (CTCs) of patients with nasopharyngeal carcinoma (NPC) and explore its significance in
Xinsa Fu +5 more
doaj +1 more source
Effects of curcumin and Cur1 on hTERT.
, 2014 A: analysis of hTERT protein expression by fluorescent immunocytochemistry(A1) and western blot(A2). A3: Quantitative analysis of western blot (A2). B: analysis of hTERT mRNA expression by real-time PCR.
Zijian Xiao (591185) +9 more
core +1 more source
The Regulation of hTERT by Alternative Splicing
, 2021 The file named "YUAN-DISSERTATION-2019.pdf" is the primary dissertation file. In addition, one (1) supplemental file -- "siRNA screen Supplemental Table.xls" -- is available and may be viewed individually.Pages xiv-xvii are misnumbered as pages viii-viii.
Yuan, Laura Yu
core
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway [PDF]
, 2017 Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Song, Chen +37 more
core +1 more source
Genes, Chromosomes and Cancer, Volume 65, Issue 6, June 2026.ABSTRACT Introduction Alterations involving RUNX1 are recurrent in hematologic malignancies and contribute to disease pathogenesis via dysregulation of transcriptional factors essential for hematopoiesis. Here, we report an acquired alteration in both alleles of RUNX1; one is a truncating mutation and the second is a novel RUNX1::ARID1B identified in ...
Rolando García +8 more
wiley +1 more source