Results 121 to 130 of about 42,636 (233)

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, Volume 13, Issue 26, 8 May 2026.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

Joint quantitative measurement of hTERT mRNA in both peripheral blood and circulating tumor cells of patients with nasopharyngeal carcinoma and its clinical significance

BMC Cancer, 2017
Background The study was aimed to quantitatively detect mRNA levels of the catalytic subunit of telomerase (hTERT) in both peripheral blood and circulating tumor cells (CTCs) of patients with nasopharyngeal carcinoma (NPC) and explore its significance in
Xinsa Fu, Congxiang Shen, Huigang Wang, Fang Chen, Guanxue Li, Zhong Wen   +5 more
doaj   +1 more source

Effect of vector-expressed shRNAs on hTERT expression

World Journal of Gastroenterology, 2005
To study the effect of short hairpin RNAs (shRNAs) expressed from DNA vector on hTERT expression.Oligonucleotides coding for four shRNAs against hTERT were cloned into a mammalian shRNA expression vector pUC18U6 to form pUC18U6ht1-4, which were then introduced into HepG2 cells by using liposome-mediated transfection.
Ying, Guo, Jun, Liu, Ying-Hui, Li, Tian-Bao, Song, Jing, Wu, Cai-Xia, Zheng, Cai-Fang, Xue   +6 more
openaire   +2 more sources

Simultaneous Establishment of Autologous Colorectal Cancer and Mesothelial Stromal Cell Lines from Malignant Ascites Reveals a Mesothelial‐Stromal FGFR3 Axis as a Potential Vulnerability in Peritoneal Metastasis

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Colorectal cancer (CRC) with peritoneal dissemination remains a major therapeutic challenge because of poor prognosis and limited treatment options. Experimental models that accurately recapitulate tumor–mesothelial interactions are scarce. Here, we report the establishment of a novel autologous paired model comprising a CRC cell line (OMUCR‐1)
Yasuhiro Fukui, Hiroaki Kasashima, Zizhou Wang, Iguru Omori, Yukina Kusunoki, Kanae Echizen, Yoshiki Nonaka, Yuki Seki, Kenji Kuroda, Yuichiro Miki, Mami Yoshii, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Yu Muta, Yuki Nakanishi, Masakazu Yashiro, Naoko Ohtani, Kiyoshi Maeda   +19 more
wiley   +1 more source

Mutation analysis of BRCA1 and BRCA2 genes in Iranian high risk breast cancer families [PDF]

Background: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization.
A Ghaderi, A Liede, A Mosavi-Jarrahi, Andrea Pietschmann, CS Healey, D Shattuck-Eidens, EL Goode, H Najmabadi, Hartmut Peters, JT den Dunnen, MA Unger, MC King, Morteza Atri, O Diez, P Mehdipour, Parvin Mehdipour, Parvin Mehdipour, R Moslehi, S Gad, S Neuhausen, S. Said Hosseini-Asl, Siegfried Scherneck, Stefan Mundlos, The, Thompson, V Yassaee, W Hofmann, Wera Hofmann, X Liu   +28 more
core   +1 more source

hTERT-based therapy: A universal anticancer approach (Review)

Oncology Reports, 2012
Human telomerase reverse transcriptase (hTERT) has been identified as a major protein involved in aberrant cell proliferation, immortalization, metastasis and stemness maintenance in a majority of tumors, yet it has little or no expression in normal somatic cells.
Mu-Han, Lü, Zhong-Li, Liao, Xiao-Yan, Zhao, Ya-Han, Fan, Xian-Long, Lin, Dian-Chun, Fang, Hong, Guo, Shi-Ming, Yang   +7 more
openaire   +3 more sources

Immortalization of Human Adult Alveolar Epithelial Cells to Study Environmental Exposures of the Distal Lung

Current Protocols, Volume 6, Issue 5, May 2026.
Abstract Alveolar epithelial cell type 1 (AT1) and type 2 (AT2) cells make up the saccular gas exchange units of the lung, called alveoli. Formation of alveoli during lung development accounts for the expansive surface area of the lung, allowing for proper respiration and delivery of oxygen to the body.
Evelyn Tran, Laurence St. Pierre, Diego Velarde, Bianca dal Bó, Juan Ramon Alvarez, Kweku Ofosu‐Asante, Nazarius S. Lamango, Yong Huang, Crystal N. Marconett, Zea Borok, Beiyun Zhou, Ite A. Offringa   +11 more
wiley   +1 more source

Acute Exercise Regulates Htert Alternative Splicing In Contractile Tissues Of Htert-bac Mice

Medicine & Science in Sports & Exercise, 2021
Aaron L. Slusher, Andrew T. Ludlow
openaire   +2 more sources

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

The association between telomerase activity and expression of its RNA component (hTR) in breast cancer patients: the importance of DNase treatment [PDF]

Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not in somatic cells.
حسینی اصل, سید سعید, مدرسی, محمد حسین, عطری, مرتضی, سلحاب, محمد, مکبل, کفاه, مهدی پور, پروین   +5 more
core   +1 more source