Results 131 to 140 of about 28,110 (249)

Prognostic value of hTERT mRNA expression in surgical samples of lung cancer patients : the European Early Lung Cancer Project

, 2010
Lung cancer is the most important cause of cancer-related mortality. Resectability and eligibility for treatment with adjuvant chemotherapy is determined by staging according to the TNM classification.
Heideman, Danielle A.M., Sozzi, Gabriella, Elborn, J. Stuart, Postmus, Pieter E., O'Byrne, Ken J., Martinet, Yves, Niklinski, Jacek, Sutedja, G. Thomas, Smit, Egbert F., Becker, Heinrich D., Van Den Berg, Remco M., Brambilla, Christian, Montuenga, Luis M., Meijer, Chris J.L.M., Snijders, Peter J.F., Brokx, Hes, Field, John K., Vesin, Aurelien, Risch, Angela, Thunnissen, Frederick B., Harrison, David J.   +20 more
core   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak, Noor Hussein, Veronica Piedra, Saloni Malla, Chandrabose Karthikeyan, Haneen Amawi, Harish Rajak, Charles R. Ashby Jr., R. Jayachandra Babu, Amit K. Tiwari   +9 more
wiley   +1 more source

Acute Exercise Regulates Htert Alternative Splicing In Contractile Tissues Of Htert-bac Mice

Medicine & Science in Sports & Exercise, 2021
Aaron L. Slusher, Andrew T. Ludlow
openaire   +2 more sources

Surface N‐Glycosylation Dictates MSC‐EV Uptake and CCR2‐Driven Monocyte Recruitment to Inflamed Endothelium Under Shear Flow

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EV) hold promising potential for immunomodulation and tissue regeneration, especially for treating ischemia‐reperfusion injury (IRI). However, their therapeutic use is hindered by challenges in tissue targeting and incomplete understanding of their functional mechanisms.
Marta Clos‐Sansalvador, Marta Monguió‐Tortajada, Sergio G. Garcia, Manuel Pérez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Diego Megías, Isabel Peset, Marcella Franquesa, Marta Hergueta‐Redondo, Hector Peinado, Francesc E. Borràs   +11 more
wiley   +1 more source

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.

PLoS ONE, 2019
Telomerase is a ribonucleoprotein ribonucleic enzyme that is essential for cellular immortalization via elongation of telomere repeat sequences at the end of chromosomes. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase
Takahito Ohira, Hirotada Kojima, Yuko Kuroda, Sayaka Aoki, Daigo Inaoka, Mitsuhiko Osaki, Hideki Wanibuchi, Futoshi Okada, Mitsuo Oshimura, Hiroyuki Kugoh   +9 more
doaj   +1 more source

Cutaneous Squamous Cell Carcinoma Amongst Solid Organ Transplant Recipients: A Systematic Review of Molecular Alterations

JEADV Clinical Practice, Volume 5, Issue 2, Page 433-457, June 2026.
ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray, Robin Caird, Michael O'Connor, Ciara Drumm, Emma O'Hora, Franklin Crossen, Aoife Lally, Aurelie Fabre, Roisin Dolan   +8 more
wiley   +1 more source

IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF MICRORNAS REGULATING HTERT

Experimental Oncology
Background. Telomerase is a ribonucleoprotein (RNP) reverse transcriptase that replicates the ends of chromosomes, thereby maintaining genome integrity, and its inhibition may be envisioned to prevent carcinogenesis or treat cancer patients. Various approaches have been used to target hTERT, and one of the promising strategies is the use of hTERT ...
Maham, Ansari, Rafiullah, Rafiullah, Abdul, Wali, Afrasiab Khan, Tareen, Imrana Niaz, Sultan, Muhammad Mushtaq, Yasinzai   +5 more
openaire   +2 more sources

Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres

, 2003
Telomerase is the ribonucleoproteic complex involved in maintaining telomere size. It is expressed in germ and stem cells but not in normal somatic cells. In most tumors, telomerase is reactivated.
Benhattar, J., Guilleret, I.
core   +1 more source

Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
A large intracellular drug‐repurposing screen identifies a potent synergy between 5‐fluoro‐2′‐deoxycytidine and rifapentine, acting through dual host–pathogen targeting to reduce Staphylococcus aureus burdens across strains, cell types, and infection models (created with BioRender).
Blanca Lorente‐Torres, Helena Á. Ferrero, Pablo Castañera, Jesús Llano‐Verdeja, Sergio Fernández‐Martínez, Amanda Herrero‐González, Farzaneh Javadimarand, Roberto López, Jesús F. Aparicio, Andrew M. Edwards, Volker Behrends, Luis M. Mateos, Álvaro Mourenza, Michal Letek   +13 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source