Results 131 to 140 of about 42,636 (233)
hTERT-immortalized ovine microglia propagate natural scrapie isolates
Virus Research, 2015 Ex vivo propagation of natural prion isolates (i.e., propagated solely in the natural host) is crucial for the characterization and study of transmissible spongiform encephalopathies (TSEs). Several well-established, prion-permissive cell culture systems are available; however, only a few cell lines are permissive to natural prion isolates and these ...
Juan F. Muñoz-Gutiérrez +5 more
openaire +2 more sources
PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.
PLoS ONE, 2019 Telomerase is a ribonucleoprotein ribonucleic enzyme that is essential for cellular immortalization via elongation of telomere repeat sequences at the end of chromosomes. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase
Takahito Ohira +9 more
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BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells [PDF]
, 2017 Telomerase activity, not detectable in somatic cells but frequently activated during carcinogenesis, confers immortality to tumors. Mechanisms governing expression of the catalytic subunit hTERT, the limiting factor for telomerase activity, still remain ...
Alberti, Loredana +7 more
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Quantum Genetics, Quantum Automata and Quantum Computation [PDF]
, 2004 The concepts of quantum automata and quantum computation are studied in the context of quantum genetics and genetic networks with nonlinear dynamics. In a previous publication (Baianu,1971a) the formal concept of quantum automaton was introduced and its ...
Baianu, Professor I. C.
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BioengineeringA fluorescent cell-based assay was developed for the screening of chemicals repressing the expression of human telomerase reverse transcriptase (hTERT).
You Li +3 more
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A Novel Approach of Virotherapy Based Hsf-1 Shrna in Cancer Eradication [PDF]
, 2013 Cancer is the second leading cause of death worldwide with continues rise mortality rate. Current cancer treatment modalities are still ineffective and associated with many side effects leading to robust research to find new specific target therapy. Heat
Supadmanaba, I. G. (I) +1 more
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RuvB12 as a regulator of hTERT
, 2019 Telomere maintenance is essential for the continued proliferation of tumour cells and is performed through the mechanism of telomerase activation or by a recombination-based process referred to as alternative lengthening of telomeres (ALT). The most important components of active telomerase are the reverse transcriptase enzyme (hTERT) and the non ...
openaire +2 more sources
TELOMERASE CATALYTIC SUBUNIT mRNA IN LARYNGEAL SQUAMOUS CELL CARCINOMAS
Zdravniški Vestnik, 2002 Background. Re-activation of the enzyme telomerase, has been detected in nearly 90% of human malignancies. In contrast, normal human somatic cells, with the exception of germ cells and stem cells of renewable tissues, do not have detectable telomerase ...
Boštjan Luzar +4 more
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The Expression of hTERT mRNA and p16 Protein in Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2009 Background and objective hTERT and p16 are involved in oncogenesis and development of tumor. The aim of this study is to investigate the expression of human telomerase reverse transcriptase (hTERT) and p16 in non-small cell lung cancer (NSCLC).
Lei XIAN +5 more
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