Results 141 to 150 of about 28,110 (249)
Immunohistochemical localization of hTERT protein in human tissues [PDF]
, 2018 Telomerase is a ribonucleoprotein complex mainly composed of a reverse transcriptase catalytic subunit (telomerase reverse transcriptase gene, hTERT) that copies a template region of its RNA subunit to the end of the telomere.
Bosman, Fred +4 more
core
The hTERT promoter sequence and proposed structure.
, 2014 Top: Sequence of the hTERT core promoter with the positions of mutations observed in melanomas shown in red. Bottom: Previously proposed structure of the hTERT core promoter (5). Adapted with permission from (5).
Donald M. Miller (636087) +6 more
core +1 more source
Phytochemical Analysis, Volume 37, Issue 4, Page 507-535, June 2026.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source
Characteristics of the HTERT-AEC II line at different passages.
, 2013 A: Cellular morphology of HTERT-AEC II cells at different passages. No obvious morphological differences in HTERT-AEC II cells at different passages were observed compared with normal AEC II cells. B: Cell proliferation abilities of HTERT-AEC II cells at
Guanghui Liu (253556) +8 more
core +1 more source
Cancer Science, Volume 117, Issue 6, Page 1531-1542, June 2026.Graphical representation of formation of self‐assembled PEGylated Chitosan Nanoparticles and their mechanism in tumor localization. ABSTRACT Polymer‐based nanocarriers have emerged as transformative platforms in cancer nanomedicine, enabling controlled and site‐specific delivery of therapeutic agents.
Prashant Kesharwani +5 more
wiley +1 more source
BioengineeringA fluorescent cell-based assay was developed for the screening of chemicals repressing the expression of human telomerase reverse transcriptase (hTERT).
You Li +3 more
doaj +1 more source
Study of hTERT and Histone 3 Mutations in Medulloblastoma.
Pathobiology : journal of immunopathology, molecular and cellular biology, 2017 Hotspot activating mutations of the telomerase reverse transcriptase (hTERT) promoter region were recently described in several tumor types. These mutations lead to enhanced expression of telomerase, being responsible for telomere maintenance and allowing continuous cell division.
Viana-Pereira, Marta +7 more
openaire +3 more sources
RNAi-mediated hTERT knockdown inhibits HSFBs growth and promotes apoptosis.
, 2014 A, hTERT mRNA expression; B, hTERT protein expression; C, proliferation; D, E, apoptosis were downregulated following RNAi-mediated hTERT knockdown.
Chao Li (145513) +13 more
core +1 more source
Cancer Science, Volume 117, Issue 6, Page 1635-1650, June 2026.SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen +7 more
wiley +1 more source
Cancer Science, Volume 117, Issue 6, Page 1736-1747, June 2026.This study investigates whether several AF2‐derived scores can predict functional scores and pathogenicity labels, and suggests that the root mean square deviation between the wild‐type and variant structures predicted by AlphaFold2 (ROWVA) may be the most effective predictor. This approach may also be applicable to other multimeric proteins.
Taiki Furutani +7 more
wiley +1 more source