Results 161 to 170 of about 23,862 (194)

Abstract C88: HPV infections, hTERT methylation and hTERT expression in patients with invasive cervical cancer

Molecular Cancer Therapeutics, 2015
Abstract Background: There is limited information of the role of hTERT methylation, hTERT expression and their association with type specific HPV infections in patients with invasive cervical cancer Objective: To analyze the possible association between methylation status of the hTERT promoter gene, hTERT expression and ...
Pablo Moreno-Acosta, Nicolas Morales, Marcela Burgos, Oscar Gamboa, Juan Carlos Mejia, Alfredo Romero-Rojas, Alba Lucia Combita, Monica Molano   +7 more
openaire   +1 more source

hTERTmethylation and expression in gastric cancer

Biomarkers, 2009
Gastric cancer is the second most prevalent cause of cancer death worldwide. DNA methylation is a common event in gastric carcinogenesis. hTERT seems to be the rate-limiting determinant of telomerase activation, which is responsible for stability and life span. hTERT hypermethylation has been associated with telomerase expression. In the present study,
Carolina Oliveira, Gigek, Mariana Ferreira, Leal, Patricia Natalia Oliveira, Silva, Luara Carolina Frias, Lisboa, Eleonidas Moura, Lima, Danielle Queiroz, Calcagno, Paulo Pimentel, Assumpção, Rommel Rodriguez, Burbano, Marilia de Arruda Cardoso, Smith   +8 more
openaire   +2 more sources

Effect of aging and exercise on hTERT expression in thymus tissue of hTERT transgenic bacterial artificial chromosome mice

GeroScience
Telomere shortening occurs with aging in immune cells and may be related to immunosenescence. Exercise can upregulate telomerase activity and attenuate telomere shortening in immune cells, but it is unknown if exercise impacts other immune tissues such as the thymus. This study aimed to examine human telomerase reverse transcriptase (hTERT) alternative
Jeongjin J. Kim, Alexander Ahn, Jeffrey Y. Ying, Jesse Pollens-Voigt, Andrew T. Ludlow   +4 more
openaire   +2 more sources

[Proliferation and hTERT expression in neuroblastoma].

Der Pathologe, 2004
Transcription of the catalytic subunit of telomerase, human Telomerase Reverse Transcriptase (hTERT), and increased tumor cell proliferation are powerful prognostic factors in neuroblastoma. We therefore investigated their relationship in a large group of neuroblastomas.RT-PCR analysis was used to discriminate between the various hTERT transcripts ...
M, Krams, P, Rudolph, D, Harms
openaire   +1 more source

Cloning of hTERT cDNA fragment and application of anti-hTERT monoclonal antibody in mechanism of laryngeal carcinogenesis.

Yi chuan xue bao = Acta genetica Sinica, 2003
The mechanism of telomerase activation is still not clear till now. In order to understand the expressional mode of telomerase and the mechanism of telomerase activation in laryngeal carcinogenesis, we cloned a fragment of hTERT cDNA and prepared a monoclonal antibody against hTERT. We performed immuno-histochemical staining in laryngeal cancer tissues
Guang-Bin, Qiu, Guang, He, Li-Guo, Gong, Zhen, Zhao, Zi-Min, Pan, Yu-Chai, Tang, Kai-Lai, Sun   +6 more
openaire   +1 more source

Alternative splicing is a developmental switch for hTERT expression

Molecular Cell, 2021
Jef Boeke, Sharon A. Savage, Michael Shen   +2 more
exaly  

hTERT

2008
openaire   +2 more sources

Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs

Journal of Pathology, 2022
Yukinari Kato, Shuichi Kaneko, Keiichi Okano   +2 more
exaly  

Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D early growth response (EGR)-1

Cancer Letters, 2016
Jin Kim, Eun Kyoung Kim
exaly  

HTERT

2011
openaire   +1 more source