Results 101 to 110 of about 28,110 (249)
Immunohistochemical localization of hTERT protein in oral carcinogenesis [PDF]
, 2005 Introduction: Human telomerase reverse transcriptase (hTERT) the catalytic subunit of telomerase is associated with cellular immortalization and tumorigenesis .In situ detection of hTERT using immunohistochemistry (IHC) allows localizing the hTERT ...
Abraham, M.T. +4 more
core +1 more source
Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis
Advanced Science, Volume 13, Issue 34, 19 June 2026.Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang +9 more
wiley +1 more source
Receptor Ck-dependent signaling regulates hTERT gene transcription
BMC Cell Biology, 2006 Background Available evidence suggests that the regulation of telomerase activity primarily depends on the transcriptional control of the human telomerase reverse transcriptase (hTERT) gene.
Varma Neelam +2 more
doaj +1 more source
, 2022 International audienceTelomerase reactivation is responsible for telomere preservation in about 90% of cancers, providing cancer cells an indefinite proliferating potential.
Júlia Sánchez-Bellver +9 more
core +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs +4 more
wiley +1 more source
Effect of vector-expressed shRNAs on hTERT expression
World Journal of Gastroenterology, 2005 To study the effect of short hairpin RNAs (shRNAs) expressed from DNA vector on hTERT expression.Oligonucleotides coding for four shRNAs against hTERT were cloned into a mammalian shRNA expression vector pUC18U6 to form pUC18U6ht1-4, which were then introduced into HepG2 cells by using liposome-mediated transfection.
Ying, Guo +6 more
openaire +2 more sources
H1299 cells expressing hTERT are resistant to compound C treatment.
, 2018 (A) H1299 cells were transfected with plasmid encoding 3×HA-hTERT to generate H1299 cells stably expressing hTERT (H1299/hTERT). Western blotting demonstrated that HA-hTERT was expressed in H1299/hTERT cells.
Minsu Jang (2817730) +6 more
core +1 more source
Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy
Aggregate, Volume 7, Issue 6, June 2026.Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao +5 more
wiley +1 more source
Evaluation of Serum Human Telomerase Reverse Transcriptase as a Novel Marker for Cervical Cancer
The International Journal of Biological Markers, 2011 Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of human telomerase and its rate-limiting component. The purpose of the present study was to investigate the diagnostic value of hTERT in serum of cervical cancer patients ...
Mahendar Porika +5 more
doaj +1 more source
Functional and gene expression analysis of hTERT overexpressed endothelial cells
, 2008 Haruna Takano1, Satoshi Murasawa1,2, Takayuki Asahara1,2,31Institute of Biomedical Research and Innovation, Kobe, Japan; 2RIKEN Center for Developmental Biology, Kobe 650-0047, Japan; 3Tokai University of School of Medicine, Tokai, JapanAbstract ...
Haruna Takano +2 more
core