Results 81 to 90 of about 42,636 (233)

New directions for the treatment of adrenal insufficiency [PDF]

, 2015
The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB)
Allen, Allende, Badylak, Bancos, Berkes, Birke, Buaas, Chamoux, Chamoux, Clipsham, Cogger, Cox, Crawford, Drucker, Dubernard, El-Khairi, Else, Faulk, Fayard, Franksson, Freedman, Gallo-Payet, Gondo, Gondo, Grodstein, Guasti, Guasti, Hardy, Hardy, Hardy, Hardy, Hatano, Huang, Huang, Ibbertson, Jadhav, Kearns, Kim, King, Laufer, Ludwig, Luo, Mazilu, Parker, Sancho-Martinez, Schimmer, Schnabel, Sonoyama, Takahashi, Tanaka, Teebken, Thomas, Thomas, Thomas, Thomas, Thomas, Val, Val, Vierbuchen, Vouillarmet, Walczak, Walczak, Wei, Wilhelm, Wong, Yazawa, Yazawa, Yazawa, Yazawa, Zupekan   +69 more
core   +2 more sources

Long Noncoding RNA H19 Mediates STAT3‐Dependent Activation of Keratinocytes and Fibroblasts in Systemic Sclerosis Skin

Arthritis &Rheumatology, EarlyView.
Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W. Wasson, Rebecca L. Ross, Francesco Del Galdo   +3 more
wiley   +1 more source

Alternative Splicing of Human Telomerase Reverse Transcriptase May Not Be Involved in Telomerase Regulation During all-trans-Retinoic Acid-Induced HL-60 Cell Differentiation

Journal of Pharmacological Sciences, 2004
Alternative splicing of the human telomerase reverse transcriptase subunit (hTERT) suppresses telomerase activity during the development of human fetal kidney cells into mature cells.
Wei-Jun Liu, Yong-Wei Zhang, Zhi-Xiang Zhang, Jian Ding   +3 more
doaj   +1 more source

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome. [PDF]

, 2015
The short rib polydactyly syndromes (SRPSs) are a heterogeneous group of autosomal recessive, perinatal lethal skeletal disorders characterized primarily by short, horizontal ribs, short limbs and polydactyly.
Daniel H. Cohn, Deborah A. Nickerson, Deborah Krakow, Ivan Duran, Jay Shendure, Michael J. Bamshad, null null, Ralph S. Lachman, Richard B. Vallee, S. Paige Taylor, Stanley F. Nelson, Sulin Wu, Tiago J. Dantas   +12 more
core   +2 more sources

p53 and hTERT Determine Sensitivity to Viral Apoptosis [PDF]

Journal of Virology, 2007
ABSTRACTApoptosis is a potent host defense against microbes. Most viruses have adapted strategies to counteract this response. Herpes simplex virus (HSV) produces a balance between pro- and antiapoptotic processes during infection. When antiapoptotic signals become limiting, infected cells die through HSV-dependent apoptosis (HDAP).
Marie L, Nguyen, Rachel M, Kraft, Martine, Aubert, Edward, Goodwin, Daniel, DiMaio, John A, Blaho   +5 more
openaire   +2 more sources

Relationship between hTERT levels and oxidative stress in epilepsy patients

Epilepsia Open, EarlyView.
Abstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Muhammed Mehdi Üremiş, Deniz Tuncel Berktaş, Nuray Üremiş, Fatma İnanç Tolun   +3 more
wiley   +1 more source

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues [PDF]

, 2006
Background Human telomerase reverse transcriptase (hTERT) is a key component for synthesis and maintenance of telomeres on chromosome ends and is required for the continued proliferation of cells.
Sæbøe-Larssen, Stein, Fossberg, Ellen, Gaudernack, Gustav   +2 more
core   +1 more source

Cutaneous Squamous Cell Carcinoma Amongst Solid Organ Transplant Recipients: A Systematic Review of Molecular Alterations

JEADV Clinical Practice, EarlyView.
ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray, Robin Caird, Michael O'Connor, Ciara Drumm, Emma O'Hora, Franklin Crossen, Aoife Lally, Aurelie Fabre, Roisin Dolan   +8 more
wiley   +1 more source

Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas

Journal of Experimental & Clinical Cancer Research, 2012
Background One of the major components of telomerase is the human telomerase reverse transcriptase (hTERT) as the catalytic protein. hTERT mRNA expression are reported to be associated with prognosis and tumor progression in several sarcomas.
Matsuo Toshihiro, Shimose Shoji, Kubo Tadahiko, Fujimori Jun, Yasunaga Yuji, Sugita Takashi, Ochi Mitsuo   +6 more
doaj   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source