Results 81 to 90 of about 23,862 (194)

Plasma Leptin, hTERT Gene Expression, and Anthropometric Measures in Obese and Non-Obese Women with Breast Cancer

Breast Cancer: Basic and Clinical Research, 2011
Introduction Expression of human telomerase reverse transcriptase (hTERT) occurs in most cancers but its relation with obesity is unclear. This study explores the association between leptin levels and anthropometric indices with hTERT mRNA levels in ...
Mohammad Rahmati-Yamchi, Nosratallah Zarghami, Mohammad Rahbani, Ali Montazeri   +3 more
doaj   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Evaluation of Serum Human Telomerase Reverse Transcriptase as a Novel Marker for Cervical Cancer

The International Journal of Biological Markers, 2011
Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of human telomerase and its rate-limiting component. The purpose of the present study was to investigate the diagnostic value of hTERT in serum of cervical cancer patients ...
Mahendar Porika, Radhika Tippani, Anwar Mohammad, Sekhar R Bollam, Sree D Panuganti, Sadanandam Abbagani   +5 more
doaj   +1 more source

microRNA‐145‐5p regulates P‐glycoprotein and breast cancer resistance protein in primary human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye, Enrrico Bloise, Nikola Ivanovski, Lubna Nadeem, Christopher Casciaro, Stephen G. Matthews   +5 more
wiley   +1 more source

Human Adipose Stem Cells Engineered to Express Carboxylesterase Confer Anti-Tumoral Efficacy of Irinotecan in Castration-Resistant Prostate Cancer Bone Metastasis Growth and Osteolysis

The World Journal of Men's Health
Purpose: Castration-resistant prostate cancer (CRPC) presents a significant clinical challenge, particularly when it metastasizes to bone, leading to skeletal-related events such as osteolysis.
Da Hyun Yun, Jae Heon Kim, Sang Hun Lee, Eun Jung Lee, Serk In Park, Yun Seob Song   +5 more
doaj   +1 more source

Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival

International Journal of Cancer, Volume 159, Issue 10, Page 2452-2462, 15 November 2026.
ABSTRACT Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this study, we measured these epigenetic markers in breast tumours and assessed their prognostic value.
Luca Li, Elaheh Zarean, Danmeng Lily Li, Yiyue Zhu, Shuai Li, Enes Makalic, Catriona McLean, Graham G. Giles, Roger L. Milne, Melissa C. Southey, Pierre‐Antoine Dugué   +10 more
wiley   +1 more source

RIF1 promotes human epithelial ovarian cancer growth and progression via activating human telomerase reverse transcriptase expression

Journal of Experimental & Clinical Cancer Research, 2018
Background Human telomerase reverse transcriptase (hTERT) is highly expressed in over 80% of tumors, including human epithelial ovarian cancer (EOC). However, the mechanisms through which hTERT is up-regulated in EOC and promotes tumor progression remain
Yong-Bin Liu, Ying Mei, Jing Long, Yu Zhang, Dong-Li Hu, Hong-Hao Zhou   +5 more
doaj   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

Nuclear Wrinkles Result From Geometric Adaptations to Cellular and Nuclear Morphological Changes in Epithelial Cells

Genes to Cells, Volume 31, Issue 6, November 2026.
Changes in cell geometry caused by increased cell density, F‐actin disruption, or trypsinization promote nuclear rounding and nuclear wrinkle (NW) formation. NWs arise through passive redistribution of excess nuclear surface area and are reversible, without detectable DNA damage, stress‐associated histone H3 Ser10 phosphorylation, or global nuclear ...
Le Minh Khoa, Yohei Kono, Takeshi Shimi, Hiroshi Kimura   +3 more
wiley   +1 more source

Effect of vector-expressed shRNAs on hTERT expression

World Journal of Gastroenterology, 2005
To study the effect of short hairpin RNAs (shRNAs) expressed from DNA vector on hTERT expression.Oligonucleotides coding for four shRNAs against hTERT were cloned into a mammalian shRNA expression vector pUC18U6 to form pUC18U6ht1-4, which were then introduced into HepG2 cells by using liposome-mediated transfection.
Ying, Guo, Jun, Liu, Ying-Hui, Li, Tian-Bao, Song, Jing, Wu, Cai-Xia, Zheng, Cai-Fang, Xue   +6 more
openaire   +2 more sources