Results 81 to 90 of about 28,110 (249)

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas

Journal of Experimental & Clinical Cancer Research, 2012
Background One of the major components of telomerase is the human telomerase reverse transcriptase (hTERT) as the catalytic protein. hTERT mRNA expression are reported to be associated with prognosis and tumor progression in several sarcomas.
Matsuo Toshihiro, Shimose Shoji, Kubo Tadahiko, Fujimori Jun, Yasunaga Yuji, Sugita Takashi, Ochi Mitsuo   +6 more
doaj   +1 more source

RuvB12 as a regulator of hTERT

, 2010
Telomere maintenance is essential for the continued proliferation of tumour cells and is performed through the mechanism of telomerase activation or by a recombination-based process referred to as alternative lengthening of telomeres (ALT). The most important components of active telomerase are the reverse transcriptase enzyme (hTERT) and the non ...
openaire   +2 more sources

Transgenic hTERT expression.

, 2018
(A) Phase-contrast images of the hTERT- immortalized cell lines (upper row) and wild type (WT) controls (lower row). Monoclonal K#4 and the polyclonal cell line show an elongated, “needle like” morphology when compared to WT fibroblasts.
Katharina Debowski (493752), Tobias Kahland (5798048), Gabriela Salinas (3517127), Sigrid Fuchs (5798051), Rüdiger Behr (705041), Stoyan Petkov (5798045), Orr Shomroni (3071487), Thomas Lingner (93705)   +7 more
core   +1 more source

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

Compound C reduces hTERT expression.

, 2018
(A, B) Compound C treatment decreases expression of hTERT mRNA and protein. HEK293T cells were treated with compound C for 12 h, and the expression of hTERT was measured by quantitative real-time PCR and western blotting. Control vs.
Minsu Jang (2817730), Ik-Soon Jang (147206), Daum Jo (6009578), Junsoo Park (147202), Rackhyun Park (735914), Eun-Ju Lee (2670493), Hyunju Kim (124616)   +6 more
core   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Inhibition of pSTAT3 down-regulated hTERT as well as hTERT knock-down down-regulated CD44.

, 2013
Targeted knock-down of STAT3 and chemical inhibition of pSTAT3 both down-regulated hTERT and CD44 expression levels. A: STAT3 shRNA mediated knock-down cells showed decreased expression levels of both hTERT and CD44.
Jaydutt V. Vadgama (388559), Clement Aroh (503438), Seyung S. Chung (503437)   +2 more
core   +1 more source

EGFR‐Targeting IgG1 Antibody Enhances NK Cell‐Mediated Tumor Killing in KRAS‐Mutant Pancreatic Cancer

MedComm, Volume 7, Issue 7, July 2026.
In KRAS‐mutant pancreatic cancer, persistent downstream signaling can limit the efficacy of EGFR‐targeting mAbs. However, the addition of NK cells enables nimotuzumab to effectively direct a potent antitumor response via antibody‐dependent cellular cytotoxicity (ADCC), overcoming this resistance mechanism.
Ruoxi Xiao, Xiaoxiao Li, Ping Li, Junjin Wang, Xiaoyuan Sun, Chenyang Zhao, Zimin Liu, Ruining Gong, Minghan Ren, Ke Lei, He Ren   +10 more
wiley   +1 more source

Functional identification and mapping of a gene that represses telomerase hTERT transcription in prostate cancer cells

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomerase is present in over 90% of tumour tissues and immortalized cells and is tightly regulated in most normal somatic cells.
Hasan, Rana
core