Results 61 to 70 of about 28,110 (249)
Arthritis &Rheumatology, EarlyView.Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz +3 more
wiley +1 more source
پیاورد سلامت, 2008 Background and Aim: Chronic Myelogenous Leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by a translocation between chromosome 9 and 22 called Philadelphia Chromosome. Telomerase- essential enzyme that adds telomeric repeats into
A Amini +7 more
doaj
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum +5 more
wiley +1 more source
Molecular Therapy: Oncolytics, 2022 Human telomerase reverse transcriptase (hTERT) is highly expressed in many tumors and is essential for tumorigenesis and metastasis in multiple cancers.
Tianze Liu +9 more
doaj +1 more source
FOXO3a enhances hTERT transcription.
, 2014 Transcriptional activation of the hTERT gene by FOXO3a was determined by normalized luciferase activity under the control of the hTERT core promoter (A) and qRT-PCR analysis of hTERT mRNA (B).
Kaori Ogawa (593584) +4 more
core +1 more source
What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?
Biotechnology and Bioengineering, EarlyView.Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady +6 more
wiley +1 more source
Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
Journal of Biomedical Science, 2018 Background Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation.
Ricardo Leão +5 more
doaj +1 more source
Role of hTERT rs2736100 in pathological scarring
Experimental and Therapeutic Medicine, 2022 Hypertrophic and atrophic scars are the effect of a dysregulated wound-healing process in genetically predisposed individuals. The genetic predisposition has acquired significant attention due to the diverse phenotype of pathological scarring in individuals with a positive personal and family history.
Roxana Flavia, Ilieș +7 more
openaire +3 more sources
Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival
International Journal of Cancer, EarlyView.ABSTRACT Breast cancer remains a major challenge to public health. Biomarkers may be useful to improve prediction of breast cancer survival. Several epigenetic markers of cell division and ageing based on DNA methylation have been proposed. In this study, we measured these epigenetic markers in breast tumours and assessed their prognostic value.
Luca Li +10 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Background Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers.
Guihong Li +11 more
doaj +1 more source