Results 21 to 30 of about 28,110 (249)
Relationship between hTERT levels and oxidative stress in epilepsy patients. [PDF]
Epilepsia OpenAbstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Üremiş MM +3 more
europepmc +2 more sources
Mapping the FEN1 interaction domain with hTERT [PDF]
Biochemical and Biophysical Research Communications, 2011 The activity of telomerase in cancer cells is tightly regulated by numerous proteins including DNA replication factors. However, it is unclear how replication proteins regulate telomerase action in higher eukaryotic cells. Previously we have demonstrated that the multifunctional DNA replication and repair protein flap endonuclease 1 (FEN1) is in ...
Sampathi, Shilpa, Chai, Weihang
openaire +3 more sources
Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells [PDF]
Carcinogenesis, 2008 Enhanced expression of human telomerase reverse transcriptase (hTERT) occurs frequently during cellular immortalization. The current study was undertaken to determine the mechanism regulating the hTERT promoter activity during cellular immortalization of human oral keratinocytes.
Reuben H, Kim +6 more
openaire +2 more sources
Detection of hTERT protein by flow cytometry [PDF]
Leukemia, 2000 Telomerase is a telomere-specific DNA polymerase consisting of protein and RNA components, which is activated in germline cells and the majority of cancers and serves to counter the consequences of telomere shortening. The protein component, hTERT, is believed to be the catalytic subunit of human telomerase and its expression at the mRNA level ...
Ali AS, Chopra R, Robertson J, Testa NG
openaire +3 more sources
, 2022 A and C show averaged titrations of hTERT and 3B1 in the absence and presence of 250 μg/mL C.T., respectively. B and D show averaged titrations of hTERT and GTC365 in the absence and presence of 250 μg/mL C.T., respectively.
Robert C. Monsen (10499524) +4 more
core +1 more source
MicroRNAs and Epigenetics Strategies to Reverse Breast Cancer
Cells, 2019 Breast cancer is a sporadic disease with genetic and epigenetic components. Genomic instability in breast cancer leads to mutations, copy number variations, and genetic rearrangements, while epigenetic remodeling involves alteration by DNA methylation ...
Mohammad Mijanur Rahman +2 more
doaj +1 more source
Long-term persistent infection of HPV 16 E6 up-regulate SP1 and hTERT by inhibiting LKB1 in lung cancer cells. [PDF]
PLoS ONE, 2017 HPV 16 E6 upregulates hTERT expression in lung cancer cells. However, the underlying molecular mechanism is unclear. In this paper, E6, LKB1, SP1, and hTERT mRNA expression levels were detected in brushing cells of patients with lung cancer (n = 106) and
Jing-Hua Yang +6 more
doaj +1 more source
NF-κB signaling and crosstalk during carcinogenesis
4 open, 2019 Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
doaj +1 more source
An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase
iScience, 2022 Summary: Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance.
Zhifen Zhou +13 more
doaj +1 more source
Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer
Cell Communication and Signaling, 2023 Telomerase reverse transcriptase (TERT/hTERT) serves as the pivotal catalytic subunit of telomerase, a crucial enzyme responsible for telomere maintenance and human genome stability.
Ruozhu Yang +7 more
doaj +1 more source