Results 21 to 30 of about 23,862 (194)
Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer
Cell Communication and Signaling, 2023 Telomerase reverse transcriptase (TERT/hTERT) serves as the pivotal catalytic subunit of telomerase, a crucial enzyme responsible for telomere maintenance and human genome stability.
Ruozhu Yang +7 more
doaj +1 more source
Detection of hTERT protein by flow cytometry [PDF]
Leukemia, 2000 Telomerase is a telomere-specific DNA polymerase consisting of protein and RNA components, which is activated in germline cells and the majority of cancers and serves to counter the consequences of telomere shortening. The protein component, hTERT, is believed to be the catalytic subunit of human telomerase and its expression at the mRNA level ...
Ali AS, Chopra R, Robertson J, Testa NG
openaire +3 more sources
Diabetes, Metabolic Syndrome and Obesity, 2022 Jian Wang,1,2 Xiaodan Zhao,3 Guichang Tian,2 Xiaochao Liu,2 Chengyan Gui,2 Lin Xu1,4 1School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic of China; 2Department of Orthopedics, Qufu Hospital of TCM, Qufu,
Wang J +5 more
doaj
FOXM1 increases hTERT protein stability and indicates poor prognosis in gastric cancer
Neoplasia: An International Journal for Oncology Research, 2023 Gastric cancer is one of most lethal diseases across the world. However, the underlying mechanism of gastric cancer carcinogenesis and development is still not fully known.
Qingyun Tang +7 more
doaj +1 more source
Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]
Jichu yixue yu linchuang, 2021 Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
doaj
Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias
Neoplasia: An International Journal for Oncology Research, 2014 Although numerous factors have been found to modulate hTERT transcription, the mechanism of its repression in certain leukemias remains unknown. We show here that DEK represses hTERT transcription through its enrichment on the hTERT promoter in cells ...
Maroun Karam +14 more
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Dynamic telomerase gene suppression via network effects of GSK3 inhibition. [PDF]
PLoS ONE, 2009 Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed.
Alan E Bilsland +10 more
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Molecular Oncology, 2020 Telomerase (hTERT) reactivation and sustained expression is a key event in the process of cellular transformation. Therefore, the identification of the mechanisms regulating hTERT expression is of great interest for the development of new anticancer ...
Delphine Garsuault +7 more
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hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer [PDF]
International Journal of Cancer, 2005 AbstractIn a majority of malignant human tumors telomerase activity can be detected, suggesting an immortal phenotype. Expression of the reverse transcriptase subunit, hTERT, in the human telomerase complex is required for telomerase activity. The regulation of hTERT, from gene level to a fully functional protein, is still a poorly understood process ...
Richard, Palmqvist +8 more
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Angewandte Chemie, EarlyView.PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng +10 more
wiley +2 more sources