A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression [PDF]
Non-Coding RNA, 2017 A novel antisense transcript was identified in the human telomerase reverse transcriptase (hTERT) promoter region, suggesting that the hTERT promoter is bidirectional.
Sanandan Malhotra +4 more
doaj +3 more sources
Anti-telomerase immune response predicts disease progression in chronic lymphocytic leukemia
Clinical Immunology Communications, 2021 Human telomerase reverse transcriptase (hTERT) is broadly expressed in many cancers. High hTERT expression have been described in chronic lymphocytic leukemia (CLL).
Claire Germain +8 more
doaj +3 more sources
Immunohistochemical localization of hTERT protein in human tissues [PDF]
Histochemistry and Cell Biology, 2018 Telomerase is a ribonucleoprotein complex mainly composed of a reverse transcriptase catalytic subunit (telomerase reverse transcriptase gene, hTERT) that copies a template region of its RNA subunit to the end of the telomere.
Benhattar, Jean +4 more
core +5 more sources
Receptor Ck-dependent signaling regulates hTERT gene transcription [PDF]
BMC Cell Biology, 2006 Background Available evidence suggests that the regulation of telomerase activity primarily depends on the transcriptional control of the human telomerase reverse transcriptase (hTERT) gene.
Varma Neelam +2 more
doaj +3 more sources
Inactivation of hTERT transcription by Tax [PDF]
Oncogene, 2003 Telomerase expression is the hallmark of tumor cells in which this ribonucleoprotein complex preserves chromosome integrity by maintaining telomere length and thereby prevents cell death. However, recent data support a role of the combination of p53 and telomerase inactivation in initiating genetic instability that promotes malignant transformation ...
Anne-Sophie, Gabet +7 more
openaire +2 more sources
Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. [PDF]
, 2014 Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection.
Chou, Jennifer P +4 more
core +6 more sources
MicroRNAs and Epigenetics Strategies to Reverse Breast Cancer
Cells, 2019 Breast cancer is a sporadic disease with genetic and epigenetic components. Genomic instability in breast cancer leads to mutations, copy number variations, and genetic rearrangements, while epigenetic remodeling involves alteration by DNA methylation ...
Mohammad Mijanur Rahman +2 more
doaj +1 more source
Silencing of the hTERT gene by shRNA inhibits colon cancer SW480 cell growth in vitro and in vivo. [PDF]
PLoS ONE, 2014 Human telomerase reverse transcriptase (hTERT) is the key enzyme responsible for synthesizing and maintaining the telomeres on the ends of chromosomes, and it is essential for cell proliferation.
Ai-Qun Liu +6 more
doaj +1 more source
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]
, 2017 Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao +18 more
core +1 more source
Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures. [PDF]
, 2014 Telomerase is a reverse transcriptase that maintains telomeres on the ends of chromosomes, allowing rapidly dividing cells to proliferate while avoiding senescence and apoptosis.
Hart, Kristina +2 more
core +1 more source