Results 11 to 20 of about 23,862 (194)
A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression [PDF]
Non-Coding RNA, 2017 A novel antisense transcript was identified in the human telomerase reverse transcriptase (hTERT) promoter region, suggesting that the hTERT promoter is bidirectional.
Sanandan Malhotra +4 more
doaj +3 more sources
Anti-telomerase immune response predicts disease progression in chronic lymphocytic leukemia
Clinical Immunology Communications, 2021 Human telomerase reverse transcriptase (hTERT) is broadly expressed in many cancers. High hTERT expression have been described in chronic lymphocytic leukemia (CLL).
Claire Germain +8 more
doaj +3 more sources
Inactivation of hTERT transcription by Tax [PDF]
Oncogene, 2003 Telomerase expression is the hallmark of tumor cells in which this ribonucleoprotein complex preserves chromosome integrity by maintaining telomere length and thereby prevents cell death. However, recent data support a role of the combination of p53 and telomerase inactivation in initiating genetic instability that promotes malignant transformation ...
Anne-Sophie, Gabet +7 more
openaire +2 more sources
Biochemistry and Biophysics Reports, 2021 Constitutive expression of human telomerase reverse transcriptase (hTERT) with DNA methylation of its promoter is a common phenomenon in tumor cells.
Mariko Mizuguchi +5 more
doaj +1 more source
Mapping the FEN1 interaction domain with hTERT [PDF]
Biochemical and Biophysical Research Communications, 2011 The activity of telomerase in cancer cells is tightly regulated by numerous proteins including DNA replication factors. However, it is unclear how replication proteins regulate telomerase action in higher eukaryotic cells. Previously we have demonstrated that the multifunctional DNA replication and repair protein flap endonuclease 1 (FEN1) is in ...
Sampathi, Shilpa, Chai, Weihang
openaire +3 more sources
Long-term persistent infection of HPV 16 E6 up-regulate SP1 and hTERT by inhibiting LKB1 in lung cancer cells. [PDF]
PLoS ONE, 2017 HPV 16 E6 upregulates hTERT expression in lung cancer cells. However, the underlying molecular mechanism is unclear. In this paper, E6, LKB1, SP1, and hTERT mRNA expression levels were detected in brushing cells of patients with lung cancer (n = 106) and
Jing-Hua Yang +6 more
doaj +1 more source
Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells [PDF]
Carcinogenesis, 2008 Enhanced expression of human telomerase reverse transcriptase (hTERT) occurs frequently during cellular immortalization. The current study was undertaken to determine the mechanism regulating the hTERT promoter activity during cellular immortalization of human oral keratinocytes.
Reuben H, Kim +6 more
openaire +2 more sources
NF-κB signaling and crosstalk during carcinogenesis
4 open, 2019 Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
doaj +1 more source
An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase
iScience, 2022 Summary: Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance.
Zhifen Zhou +13 more
doaj +1 more source
Biology Open, 2018 Telomerase and its core component, telomerase reverse transcriptase (hTERT), are critical for stem cell compartment integrity. Normal adult stem cells have the longest telomeres in a given tissue, a property mediated by high hTERT expression and high ...
Ahmed El-Badawy +6 more
doaj +1 more source