Results 11 to 20 of about 28,110 (249)

A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression [PDF]

Non-Coding RNA, 2017
A novel antisense transcript was identified in the human telomerase reverse transcriptase (hTERT) promoter region, suggesting that the hTERT promoter is bidirectional.
Sanandan Malhotra, Mallory A. Freeberg, Shelby J. Winans, James Taylor, Karen L. Beemon   +4 more
doaj   +4 more sources

Dynamic telomerase gene suppression via network effects of GSK3 inhibition. [PDF]

PLoS ONE, 2009
Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed.
Alan E Bilsland, Stacey Hoare, Katrina Stevenson, Jane Plumb, Natividad Gomez-Roman, Claire Cairney, Sharon Burns, Kyle Lafferty-Whyte, Jon Roffey, Tim Hammonds, W Nicol Keith   +10 more
doaj   +3 more sources

Anti-telomerase immune response predicts disease progression in chronic lymphocytic leukemia

Clinical Immunology Communications, 2021
Human telomerase reverse transcriptase (hTERT) is broadly expressed in many cancers. High hTERT expression have been described in chronic lymphocytic leukemia (CLL).
Claire Germain, Julie Garibal, Valérie Doppler, Fanny Baran-Marszak, Florence Cymbalista, Julien Caumartin, Pierre Langlade-Demoyen, Maria Wehbe, Thierry Huet   +8 more
doaj   +3 more sources

hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer [PDF]

International Journal of Cancer, 2005
AbstractIn a majority of malignant human tumors telomerase activity can be detected, suggesting an immortal phenotype. Expression of the reverse transcriptase subunit, hTERT, in the human telomerase complex is required for telomerase activity. The regulation of hTERT, from gene level to a fully functional protein, is still a poorly understood process ...
Richard, Palmqvist, Anju, Zhang, Dawei, Xu, Irina, Golovleva, Karl-Fredrik, Norrback, Astrid, Gruber, Ake, Oberg, Roger, Stenling, Göran, Roos   +8 more
openaire   +3 more sources

Immunohistochemical localization of hTERT protein in human tissues [PDF]

Histochemistry and Cell Biology, 2004
Telomerase is a ribonucleoprotein complex mainly composed of a reverse transcriptase catalytic subunit (telomerase reverse transcriptase gene, hTERT) that copies a template region of its RNA subunit to the end of the telomere. For detecting telomerase activity in a tissue specimen the TRAP assay is a relatively sensitive and specific method, but it can
Yan, P., Benhattar, J., Seelentag, W., Stehle, J. C., Bosman, F. T.   +4 more
openaire   +5 more sources

Plasma Leptin, hTERT Gene Expression, and Anthropometric Measures in Obese and Non-Obese Women with Breast Cancer

Breast Cancer: Basic and Clinical Research, 2011
Introduction Expression of human telomerase reverse transcriptase (hTERT) occurs in most cancers but its relation with obesity is unclear. This study explores the association between leptin levels and anthropometric indices with hTERT mRNA levels in ...
Mohammad Rahmati-Yamchi, Nosratallah Zarghami, Mohammad Rahbani, Ali Montazeri   +3 more
doaj   +2 more sources

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis [PDF]

BMC Cancer, 2010
Background Activation of telomerase resulting from deregulated hTERT expression is a key event during high-risk human papillomavirus (hrHPV)-induced cervical carcinogenesis. In the present study we examined hTERT promoter activity and its relation to DNA
Snijders Peter JF, Meijer Chris JLM, Claassen-Kramer Debbie, Overmeer Renée M, Kooter Jan M, de Wilde Jillian, Steenbergen Renske DM   +6 more
doaj   +2 more sources

hTERTmethylation and expression in gastric cancer

Biomarkers, 2009
Gastric cancer is the second most prevalent cause of cancer death worldwide. DNA methylation is a common event in gastric carcinogenesis. hTERT seems to be the rate-limiting determinant of telomerase activation, which is responsible for stability and life span. hTERT hypermethylation has been associated with telomerase expression. In the present study,
Carolina Oliveira, Gigek, Mariana Ferreira, Leal, Patricia Natalia Oliveira, Silva, Luara Carolina Frias, Lisboa, Eleonidas Moura, Lima, Danielle Queiroz, Calcagno, Paulo Pimentel, Assumpção, Rommel Rodriguez, Burbano, Marilia de Arruda Cardoso, Smith   +8 more
openaire   +3 more sources

CDC5L Promotes hTERT Expression and Colorectal Tumor Growth

Cellular Physiology and Biochemistry, 2017
Background/Aims: Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide because the survival rate remains low. Cell division cycle 5-like (CDC5L) is highly expressed in some cancer cells, but the mechanism requires ...
Jia Li, Ningning Zhang, Rui Zhang, Longmei Sun, Wendan Yu, Wei Guo, Yingying Gao, Mei Li, Wei Liu, Pin Liang, Wuguo Deng, Xiaonan Cui   +11 more
doaj   +2 more sources

Inactivation of hTERT transcription by Tax [PDF]

Oncogene, 2003
Telomerase expression is the hallmark of tumor cells in which this ribonucleoprotein complex preserves chromosome integrity by maintaining telomere length and thereby prevents cell death. However, recent data support a role of the combination of p53 and telomerase inactivation in initiating genetic instability that promotes malignant transformation ...
Anne-Sophie, Gabet, Franck, Mortreux, Pierre, Charneau, Patrice, Riou, Madeleine, Duc-Dodon, Yalin, Wu, Kuan-Teh, Jeang, Eric, Wattel   +7 more
openaire   +2 more sources