Results 41 to 50 of about 570,627 (165)

Prognostic Relevance of hTERT mRNA Expression in Ductal Adenocarcinoma of the Pancreas

Neoplasia: An International Journal for Oncology Research, 2008
Telomerase is thought to play an essential role in tumorigenesis and progression. Its activity is directly correlated with the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT).
Lukasz-Filip Grochola, Thomas Greither, Helge W. Taubert, Peter Möller, Uwe Knippschild, Andrej Udelnow, Doris Henne-Bruns, Peter Würl   +7 more
doaj   +1 more source

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. [PDF]

PLoS Genetics, 2015
The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690,
Anagha Killedar, Michael D Stutz, Alexander P Sobinoff, Christopher G Tomlinson, Tracy M Bryan, Jonathan Beesley, Georgia Chenevix-Trench, Roger R Reddel, Hilda A Pickett   +8 more
doaj   +1 more source

Involvement of Telomerase Reverse Transcriptase in Heterochromatin Maintenance [PDF]

Molecular and Cellular Biology, 2014
In the fission yeast Schizosaccharomyces pombe, centromeric heterochromatin is maintained by an RNA-directed RNA polymerase complex (RDRC) and the RNA-induced transcriptional silencing (RITS) complex in a manner that depends on the generation of short interfering RNA.
Yoshiko, Maida, Mami, Yasukawa, Naoko, Okamoto, Seii, Ohka, Keita, Kinoshita, Yasushi, Totoki, Takashi K, Ito, Tohru, Minamino, Hiromi, Nakamura, Satoko, Yamaguchi, Tatsuhiro, Shibata, Kenkichi, Masutomi   +11 more
openaire   +2 more sources

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Neoplasia: An International Journal for Oncology Research, 2000
Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence.
Xiaoming Yi, Dennis M. White, Dara L. Aisner, Joseph A. Baur, Woodring E. Wright, Jerry W. Shay   +5 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Role of telomerase expression in interstitial lung diseases

The Egyptian Journal of Bronchology, 2019
Background Telomeres are hexameric nucleotide sequences. The biological role of telomeres is to prevent shortening of DNA to preserve integrity of the genome. Length of telomeres is determined by age, sex, and environmental exposures.
Marwa M. Shaban, Radwa A. Elhefny, Sabah H. Hussein, Amul A. Badr, Zeinab A. Nour   +4 more
doaj   +1 more source

Telomeres and Cancer

Life, 2021
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin ...
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn   +7 more
doaj   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase [PDF]

Nature Structural & Molecular Biology, 2005
Telomerase maintains the simple sequence repeats at chromosome ends, protecting cells from genomic rearrangement, proliferative senescence and death. The telomerase reverse transcriptase (TERT) and telomerase RNA (TER) alone can assemble into active enzyme in a heterologous cell extract, but the physiological process of telomerase biogenesis is more ...
Ramadevi, Prathapam, Keren L, Witkin, Catherine M, O'Connor, Kathleen, Collins   +3 more
openaire   +2 more sources

Telomerase promoter mutations in human immunodeficiency virus-related conjunctiva neoplasia

Journal of Translational Medicine, 2018
Background Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection.
Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source