Results 41 to 50 of about 28,516 (233)
Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression [PDF]
, 2013 Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the ...Hayes, R B, Schumacher, Fredrick, Severi, G., Berndt, S.I., Key, Timothy, Berndt SI, Spurdle A, Dicks, E, Ingles, SA, Le Marchand L, Muir, K; id_orcid, Ingles, S., Albanes, D, Canzian, F., Cybulski, C., Easton DF, Riboli, E., Halim, Silvia, Govindasami, K, Muir, Ken, Conroy, Don, Thobodeau, S.N, Eeles RA, Vogel, W., Muir, K, Hamdy, Freddie C., Leongamornlert, DA, Bacot F, Guy, Michelle, Wilkinson, R.A., Dunning, A.M., Albanes, D., Benlloch, S, Russell R, Clements, Judith A., Key TJ, Al Olama AA, Pharoah P, Morgan, A., Tymrakiewicz, M., Travis RC, Lee, A., Benlloch, S., Hamdy, FC, Stanford, JL, Batra, J., Ingles, Sue A., John, EM, Berndt, Sonja I., Giles, Graham G., Hunter, D.J., Donovan, JL, Wilkinson RA, Thibodeau, Stephen N., Kibel AS, Dadaev T, Luccarini C, Khaw KT, Kraft, P., Gapstur, Susan, Vogel W, Park, Jong Y., Stanford, Janet L., Bojesen SE, Kaneva, Radka, Ostrander, Elaine A., Wilkinson, Rosemary A., Haiman, Christopher A., Batra, J, Ostrander, E A, John EM, Key, Tim J., Schleutker J, Haiman, C.A., Lubinski, Jan, Thibodeau, S N, Lindstrom, S, Schleutker, J, Tessier DC, Key, T J, Maier, C., Le Marchand, Loic, Dunning, AM, John, E.M., Easton, DF, Campa, D., Russel, R, Henderson BE, Ostrander, EA, Spurdle, A., Khaw, KT, Easton, D F, Kaneva, R., Henderson, B E, Hamdy FC, Muir, K.R., Vincent D, Russell, R, Donovan, Jenny, Kraft, P, Khaw, K-T, Clements JA, Guy M, Dennis, Joe, Marchand, LL, Gapstur, S., Sawyer, E.J., Neal, David E., Leongamornlert, D.A., John, Esther M., Albanes, Demetrius, Stanford, J.L., Jugurnauth-Little, Sarah, Kibel, AS, Schaid, D., Cybulski, C, Ingles SA, Govindasami, Koveela, Lubinski, J, Wiklund, F., Donovan JL, Riboli, E, Donovan, J L, Hayes RB, Gronberg, H, Hamdy, F.C., Batra, Jyotsna, Signorello, L.B., Ross Adams H, Campa, Daniele, Gapstur, S, Travis, Ruth, Neal, D E, Wilkinson, RA, Signorello, Lisa B., Key, T.J., Pharoah, P, Muir, Kenneth, Dennis, J, Ghoussaini, M., Lindstrom, S., Neal, DE, Hunter DJ, Dadaev, T, Bojesen, Stig E., Canzian, F, John, E M, Vincent, Daniel, Eeles, RA, Ostrander, E.A., Ross-Adams, Helen, Park JY, Park, JY, Saunders, EJ, Hamdy, F C, Dadaev, T., Baynes, C., Signorello, L B, Wilkinson, R A, Muir K, Bojesen, S E, Haiman CA, Saunders, E J, Baynes, Caroline, Dennis, J., Andriole G, Ross-Adams, H., Henderson, BE, Teixeira, M R, Baynes, C, Dennis J, Gronberg, Henrik, Sawyer EJ, Vincent, D., Campa, D, Saunders, E., Pharoah, Paul, Tessier, DC, Teixeira, M.R., Hunter, David J., Hunter, D J, Chanock, Stephen, Tymrakiewicz, M, Maier C, COGS CRUK GWAS ELLIPSE Initiative, Kaneva R, Travis, R C, Signorello, LB, Kote-Jarai, Z., Cybulski, Cezary, Baynes C, Donovan, J.L., Weischer, Maren, Park, J Y, Leongamornlert DA, Ostrander EA, Lubinski J, Luccarini, Craig, Dicks E, Cannon-Albright, L., Cannon-Albright, Lisa, Marchand, L L, Travis, Ruth C., Giles, GG, Ross-Adams, H, Pharoah, P., Giles, Graham, Kibel, Adam S., Kaneva, R, Neal DE, Khaw, Kay-Tee, Bacot, François, Haiman, CA, Teixeira, MR, Teixeira, Manuel R., Al Olama, AA, Giles, G G, Halim S, Key, TJ, Andriole, Gerald, Tessier, Daniel C., Benlloch, Sara, Conroy D, Hunter, DJ, Schumacher, F, Stanford JL, Schleutker, Johanna, Donovan, Jenny L., Brenner, H., Wiklund, F, Kraft, Peter, Brenner H, Al Olama, A A, Kaaks, Rudolf, Canzian F, Luccarini, C, Andriole, G, Clements, J., Canzian, Federico, Kaaks R, Conroy, D.K., Severi G, Park, J.Y., Severi, G, Signorello LB, Schleutker, J., Tymrakiewicz M, Cannon-Albright, L, Jugurnauth Little S, Bojesen, SE, Saunders EJ, Tessier, D.C., Riboli E, Spurdle, A, Bacot, F, Schaid D, Neal, D.E., Severi, Gianluca, Vincent, D, Henderson, Brian E., Vogel, Walther, Russel, Roslin, Ingles, S A, Albanes D, Khaw, K T, Batra J, Dunning AM, Gapstur S, Tessier, D C, Travis, RC, Morgan, Angela, PRACTICAL Consortium, Cybulski C, Weischer, M, Weischer M, Haiman, C A, Schaid, Dan, Conroy, D, Cannon Albright L, Bacot, F., Luccarini, C., Kote-Jarai, Zsofia, Sawyer, Emma J., Chanock, S, Maier, C, Teixeira MR, Chanock, S., UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, Gronberg, H., Vogel, W, Schumacher F, Kote-Jarai, Z, Brenner, H, Saunders, Edward J., Weischer, M., Govindasami, K., Wiklund F, Le Marchand, L., Kote Jarai Z, Benlloch S, Maier, Christiane, Guy, M, Easton, Douglas F., Amin Ali, A.L., Travis, R.C., Guy, M., Dadaev, Tokhir, Henderson, B.E., Tymrakiewicz, Malgorzata, Wiklund, Fredrik, Hayes, R.B., Govindasami K, Thibodeau, SN, Kibel, A S, UK ProtecT Study Collaborators, Clements, JA, Giles, G.G., Clements, J A, Thibodeau SN, Lubinski, J., Al Olama, Ali Amin, Kraft P, Russel, R., Jugurn-Little, S, Eeles, R A, Dunning, Alison M., Schaid, D, Stanford, J L, Berndt, SI, Chanock S, Eeles, R.A., Le Marchand, L, Leongamornlert, D A, Sawyer, E J, Andriole, G., Dicks, E., Easton, D.F., Giles GG, Pashayan, N., Hayes, Richard B., Lindstrom, Sara, Hamdy, Freddie, Kibel, A.S, Spurdle, Amanda, Morgan, A, Sawyer, EJ, Leongamornlert, Daniel A., Dicks, Ed, Morgan A, Brenner, Hermann, Gronberg H, Schumacher, F.R., Lindstrom S, Jugurnath-Little, S., Halim, S., Hayes, RB, Kaaks, R, Dunning, A M, Jugurnauth-Little, S, Eeles, Rosalind A., Halim, S, Berndt, S I +361 morecore +1 more sourceInvolvement of Telomerase Reverse Transcriptase in Heterochromatin Maintenance [PDF]
Molecular and Cellular Biology, 2014 In the fission yeast Schizosaccharomyces pombe, centromeric heterochromatin is maintained by an RNA-directed RNA polymerase complex (RDRC) and the RNA-induced transcriptional silencing (RITS) complex in a manner that depends on the generation of short interfering RNA.Yoshiko, Maida, Mami, Yasukawa, Naoko, Okamoto, Seii, Ohka, Keita, Kinoshita, Yasushi, Totoki, Takashi K, Ito, Tohru, Minamino, Hiromi, Nakamura, Satoko, Yamaguchi, Tatsuhiro, Shibata, Kenkichi, Masutomi +11 moreopenaire +2 more sourcesA telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase [PDF]
Nature Structural & Molecular Biology, 2005 Telomerase maintains the simple sequence repeats at chromosome ends, protecting cells from genomic rearrangement, proliferative senescence and death. The telomerase reverse transcriptase (TERT) and telomerase RNA (TER) alone can assemble into active enzyme in a heterologous cell extract, but the physiological process of telomerase biogenesis is more ...Ramadevi, Prathapam, Keren L, Witkin, Catherine M, O'Connor, Kathleen, Collins +3 moreopenaire +2 more sourcesAncestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. [PDF]
PLoS Genetics, 2011 The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property known ...Jonathan K Alder, Joy D Cogan, Andrew F Brown, Collin J Anderson, William E Lawson, Peter M Lansdorp, John A Phillips, James E Loyd, Julian J-L Chen, Mary Armanios +9 moredoaj +1 more sourceImplications of telomerase reverse transcriptase in tumor metastasis
BMB Reports, 2020 Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic ...Zou, Yongkang, Cong, Yu-sheng, Zhou, Junzhi +2 moreopenaire +3 more sourcesMDM2 negatively regulates the human telomerase RNA gene promoter [PDF]
, 2005 <b>Background:</b>
We have previously demonstrated that NF-Y and Sp1 interact with the human telomerase RNA (hTR) promoter and play a central role in its regulation. We have also shown that pRB activates the hTR promoter, but the mechanism Jiangqin Zhao (6471), Keith, W.N., Katrina Jackson (6473), Bilsland, A., Jackson, K., Keith W Nicol, Alan Bilsland (6472), Zhao, J., Zhao Jiangqin, Bilsland Alan, Jackson Katrina, W. Nicol Keith (261494) +11 morecore +1 more source
