Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. [PDF]
PLoS Genetics, 2011 The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property known ...
Jonathan K Alder +9 more
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AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model [PDF]
, 2016 Limitless replicative potential is one of the hallmarks of cancer that is mainly due to the activity of telomerase. This holoenzyme maintains telomere length, adding TTAGGG repetitions at the end of chromosomes in each cell division.
Armando, Romina Gabriela +2 more
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Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast
Nature Communications, 2018 The core of the telomerase holoenzyme is composed of the reverse transcriptase and the non-coding RNA template. Here the authors identify Pof8 as a new constitutive component of fission yeast telomerase, loss of which causes telomerase assembly defects ...
Diego J. Páez-Moscoso +5 more
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Telomerase catalysis: A phylogenetically conserved reverse transcriptase [PDF]
Proceedings of the National Academy of Sciences, 1998 Replication of telomeres, the ends of eukaryotic chromosomes, is the responsibility of the enzyme telomerase. Since its discovery 13 years ago, research on this unusual DNA polymerase has revealed a series of surprises. The first of these was the realization that information within the enzyme itself determines the sequence of its product: a portion of ...
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Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells [PDF]
, 2016 open7siBesides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions.
Celeghin, Andrea +6 more
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Haematologica, 2012 Background Chronic idiopathic neutropenia is characterized by immune-mediated suppression of neutrophil production. Because patients with immune-mediated bone marrow failure syndromes display age-inappropriate telomere shortening in leukocytes, we ...
Konstantia I. Pavlaki +5 more
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Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases
Biomedicines, 2021 Telomerase is an enzyme that in its canonical function extends and maintains telomeres, the ends of chromosomes. This reverse transcriptase function is mainly important for dividing cells that shorten their telomeres continuously.
Gabriele Saretzki, Tengfei Wan
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Implications of telomerase reverse transcriptase in tumor metastasis
BMB Reports, 2020 Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic ...
Zou, Yongkang +2 more
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Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]
, 2018 BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina +6 more
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Functional Multimerization of the Human Telomerase Reverse Transcriptase [PDF]
Molecular and Cellular Biology, 2001 The telomerase enzyme exists as a large complex (approximately 1,000 kDa) in mammals and at minimum is composed of the telomerase RNA and the catalytic subunit telomerase reverse transcriptase (TERT). In Saccharomyces cerevisiae, telomerase appears to function as an interdependent dimer or multimer in vivo (J. Prescott and E. H.
T L, Beattie +3 more
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