Haematologica, 2012 Background Chronic idiopathic neutropenia is characterized by immune-mediated suppression of neutrophil production. Because patients with immune-mediated bone marrow failure syndromes display age-inappropriate telomere shortening in leukocytes, we ...
Konstantia I. Pavlaki +5 more
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Telomerase in Brain: The New Kid on the Block and Its Role in Neurodegenerative Diseases
Biomedicines, 2021 Telomerase is an enzyme that in its canonical function extends and maintains telomeres, the ends of chromosomes. This reverse transcriptase function is mainly important for dividing cells that shorten their telomeres continuously.
Gabriele Saretzki, Tengfei Wan
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The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation.
Newbold, RF, Kirkpatrick, KL, Mokbel, K
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Telomeres in Evolution and Development from Biosemiotic Perspective
, 2007 Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
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Telomerase RNA Bound by Protein Motifs Specific to Telomerase Reverse Transcriptase [PDF]
Molecular Cell, 2000 Telomerase reverse transcriptase (TERT) differs from many other reverse transcriptases in that it remains stably associated with its template-containing RNA subunit. Elements of TERT involved in binding the RNA subunit have now been identified by mutagenesis and in vitro reconstitution of the Tetrahymena ribonucleoprotein complex.
Bryan, Tracy M. +2 more
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LARP7 family proteins have conserved function in telomerase assembly
Nature Communications, 2018 The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.
Laura C. Collopy +11 more
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Prognostic Relevance of hTERT mRNA Expression in Ductal Adenocarcinoma of the Pancreas
Neoplasia: An International Journal for Oncology Research, 2008 Telomerase is thought to play an essential role in tumorigenesis and progression. Its activity is directly correlated with the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT).
Lukasz-Filip Grochola +7 more
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A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. [PDF]
PLoS Genetics, 2015 The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690,
Anagha Killedar +8 more
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The association between telomerase activity and expression of its RNA component (hTR) in breast cancer patients: the importance of DNase treatment [PDF]
Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not in somatic cells.
حسینی اصل, سید سعید +5 more
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An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity
Neoplasia: An International Journal for Oncology Research, 2000 Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence.
Xiaoming Yi +5 more
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