Results 61 to 70 of about 45,103 (233)

The Mechanisms of Telomere and Telomerase Regulation in Hematologic Malignancies [PDF]

, 2014
11518
AKIYAMA,　Masaharu, KAWAUCHI,　Kiyotaka, YAMADA,　Osamu   +2 more
core   +4 more sources

Telomerase promoter mutations in human immunodeficiency virus-related conjunctiva neoplasia

Journal of Translational Medicine, 2018
Background Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection.
Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source

Telomeres and Cancer

Life, 2021
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin ...
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn   +7 more
doaj   +1 more source

Many Disease-Associated Variants of hTERT Retain High Telomerase Enzymatic Activity [PDF]

, 2013
Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer.
Campbell, Kristina, Cech, Thomas R, Crary, Sharon M, Fioravanti, Matthew Jesse, Zaug, Arthur J   +4 more
core   +5 more sources

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Telomerase reverse transcriptase promoter mutations in bladder cancer: High frequency across stages, detection in urine, and lack of association with outcome [PDF]

, 2014
Background Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression.
Abas, C.S. (Cheno), Allory, Y. (Yves), Beukers, W. (Willemien), Carrato, A. (Alfredo), Carrillo-de Santa Pau, E. (Enrique), Dyrskjot, L. (Lars), Flández, M. (Marta), Keur, K.A. (Kirstin) van der, Kogevinas, M. (Manolis), Lloreta, J. (Josep), Lorente, J.A. (José), Lurkin, I. (Irene), Malats, N. (Núria), Marqués, M. (Miriam), Masius, R.G. (Roy), Márquez, M. (Mirari), Orntoft, T.F. (Torben), Real, F.X. (Francisco), Sagrera, A. (Ana), Steyerberg, E.W. (Ewout), Tilborg, A.A.G. (Angela) van, Vermeij, M. (Marcel), Zuiverloon, T.C.M. (Tahlita), Zwarthoff, E.C. (Ellen)   +23 more
core   +4 more sources

Telomerase reverse transcriptase subunit immunoreactivity [PDF]

Cancer, 2002
AbstractBACKGROUNDTelomerase, a ribonucleoprotein complex that maintains telomeric DNA, has been detected in 67–93% of prostate carcinomas by telomeric repeat‐amplification protocol assay (involving polymerase chain reaction). One study used in situ hybridization in nine patients; however, to date, no immunohistochemical results have been published ...
Kenneth A, Iczkowski, Cooley G, Pantazis, Douglas H, McGregor, Yaping, Wu, Ossama W, Tawfik   +4 more
openaire   +2 more sources

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Expression of Telomerase Activity, Human Telomerase RNA, and Telomerase Reverse Transcriptase in Gastric Adenocarcinomas [PDF]

Modern Pathology, 2003
Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA onto chromosome ends to compensate for sequence loss during DNA replication. It has been detected in 85-90% of all primary human cancers, implicating that the telomerase seems to be reactivated in tumors and that such activity may play a role in the tumorigenic process.
Jinyoung, Yoo, Sonya Y, Park, Seok Jin, Kang, Byung Kee, Kim, Sang In, Shim, Chang Suk, Kang   +5 more
openaire   +2 more sources

The simultaneous effect of valproic acid and gamma radiation on telomerase activity and bax and Bcl-2 protein levels in MCF-7 breast cancer cell line [PDF]

, 2015
Background: Breast cancer is one of the most prevalent types of cancer. Factors such as ionizing radiation and chemotherapeutic agents can trigger apoptosis and cancer cell death.
Asadi, J., Binabaj, M.M., Hosseini, S.A., Khoshnazar, A.K.   +3 more
core   +1 more source