Results 61 to 70 of about 24,987 (188)

Telomerase RNA Bound by Protein Motifs Specific to Telomerase Reverse Transcriptase [PDF]

Molecular Cell, 2000
Telomerase reverse transcriptase (TERT) differs from many other reverse transcriptases in that it remains stably associated with its template-containing RNA subunit. Elements of TERT involved in binding the RNA subunit have now been identified by mutagenesis and in vitro reconstitution of the Tetrahymena ribonucleoprotein complex.
Bryan, Tracy M., Goodrich, Karen J., Cech, Thomas R.   +2 more
openaire   +2 more sources

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle

Nature Communications
In most eukaryotes, the reverse transcriptase telomerase counteracts telomere shortening by processively adding telomeric DNA repeat sequences to chromosome ends.
Sebastian Balch, Elsa Franco-Echevarría, George E. Ghanim, Rachael C. Kretsch, Rhiju Das, Thi Hoang Duong Nguyen   +5 more
doaj   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Telomerase: An exploration toward the end of cancer

Indian Journal of Dental Research, 2017
Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells.
Deepika Bablani Popli, Keya Sircar, Aman Chowdhry   +2 more
doaj   +1 more source

The T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase wild-type A case report

Acta Radiologica Open, 2023
We present a case of the T2-FLAIR mismatch sign in glioblastoma, isocitrate dehydrogenase (IDH )-wild type. The T2-FLAIR mismatch sign is known as a highly specific imaging finding of astrocytoma, IDH -mutant.
Shunsuke Nishimura, Koji Yamashita, Osamu Togao, Kazufumi Kikuchi, Daisuke Kuga, Hidetaka Yamamoto, Koji Yoshimoto, Kousei Ishigami   +7 more
doaj   +1 more source

Urinary Small Extracellular Vesicle DNA as a Biomarker for the Non‐Invasive Diagnosis of Bladder Cancer

Cancer Science, EarlyView.
Clinical application scenarios for the diagnosis of BC. A schematic diagram illustrating the use of sEV DNA liquid biopsy technology to differentiate between benign and bladder cancer patients. ABSTRACT Existing diagnostic technologies for bladder cancer (BC) suffer from low sensitivity, low specificity, or a lack of validation.
Tao Wang, Xin Liao, Jiyang Zhang, Xiaoya Xu, Wei Zhang, Xinlin Chen, Xinyu Zhai, Tongtong Zhang, Xiangyang Zhan, Xingyu Mu, Dadong Zhang, Jian Chen, Dongliang Xu, Mingyue Tan   +13 more
wiley   +1 more source

The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo [PDF]

PeerJ, 2016
Telomerase core enzyme minimally consists of the telomerase reverse transcriptase domain-containing protein (Est2 in budding yeast S. cerevisiae) and telomerase RNA, which contains the template specifying the telomeric repeat sequence synthesized.
Tet Matsuguchi, Elizabeth Blackburn
doaj   +2 more sources

Telomerase reverse transcriptase in the regulation of gene expression

BMB Reports, 2014
Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis. Telomerase is essentially composed of an RNA component, Telomerase RNA or TERC, which serves as a template for telomeric DNA synthesis, and a catalytic subunit, telomerase reverse ...
Zhou, Junzhi, Ding, Deqiang, Wang, Miao, Cong, Yu-Sheng   +3 more
openaire   +3 more sources

TERT Promoter Mutations Are Preferentially Associated With the ERBB2 G776‐Altered Subtype of HER2‐Mutant NSCLC

Cancer Science, EarlyView.
A two‐stage clinicogenomic analysis identified and independently validated a preferential association between TERT promoter mutations and the ERBB2 G776‐altered subtype of HER2‐mutant NSCLC, highlighting subtype‐specific genomic heterogeneity. ABSTRACT HER2‐mutant non‐small cell lung cancer (NSCLC) comprises molecularly heterogeneous tumors with ...
Akihiro Yoshimura, Juichiro Yoshida, Chieko Takumi, Koichi Takayama   +3 more
wiley   +1 more source