Results 61 to 70 of about 570,627 (165)

Alternative Splicing of Human Telomerase Reverse Transcriptase May Not Be Involved in Telomerase Regulation During all-trans-Retinoic Acid-Induced HL-60 Cell Differentiation

Journal of Pharmacological Sciences, 2004
Alternative splicing of the human telomerase reverse transcriptase subunit (hTERT) suppresses telomerase activity during the development of human fetal kidney cells into mature cells.
Wei-Jun Liu, Yong-Wei Zhang, Zhi-Xiang Zhang, Jian Ding   +3 more
doaj   +1 more source

Proteomic identification of proteins differentially expressed following overexpression of hTERT (human telomerase reverse transcriptase) in cancer cells. [PDF]

PLoS ONE, 2017
Reverse transcriptase activity of telomerase adds telomeric repeat sequences at extreme ends of the newly replicated chromosome in actively dividing cells.
Rishi Kumar Jaiswal, Pramod Kumar, Amod Sharma, Deepak Kumar Mishra, Pramod Kumar Yadava   +4 more
doaj   +1 more source

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

Telomerase catalysis: A phylogenetically conserved reverse transcriptase [PDF]

Proceedings of the National Academy of Sciences, 1998
Replication of telomeres, the ends of eukaryotic chromosomes, is the responsibility of the enzyme telomerase. Since its discovery 13 years ago, research on this unusual DNA polymerase has revealed a series of surprises. The first of these was the realization that information within the enzyme itself determines the sequence of its product: a portion of ...
openaire   +2 more sources

Telomerase RNA Bound by Protein Motifs Specific to Telomerase Reverse Transcriptase [PDF]

Molecular Cell, 2000
Telomerase reverse transcriptase (TERT) differs from many other reverse transcriptases in that it remains stably associated with its template-containing RNA subunit. Elements of TERT involved in binding the RNA subunit have now been identified by mutagenesis and in vitro reconstitution of the Tetrahymena ribonucleoprotein complex.
Bryan, Tracy M., Goodrich, Karen J., Cech, Thomas R.   +2 more
openaire   +2 more sources

Study on immortalization of Mongolian sheep fibroblast cells

Animal Biotechnology
This study aims to establish an immortalized fibroblast cell line from Mongolian sheep. Primary Mongolian sheep fibroblasts (SSF) were isolated using tissue explant and enzymatic digestion methods, followed by microscopic observation, growth curve ...
Bin. Liu, Shichao. Wang, Fanhua. Meng, Bei. Wu, Yanru Zhang, Junwei. Cao   +5 more
doaj   +1 more source

Telomerase reverse transcriptase gene amplification in hematological malignancies

Egyptian Journal of Medical Human Genetics, 2019
Background Telomere is a complex DNA–protein structure located at the end of all eukaryotic chromosomes. The major role of human telomerase is to catalyze the addition of telomeric repeat sequences TTAGGG onto chromosome ends for stabilization of ...
Amany H. Abdelrahman, Maha M. Eid, Mirhane Hassan, Ola M. Eid, Rania M. A. AbdelKader, Nevin M. AlAzhary, Rasha Y. Shahin, Mohamed T. Sallam   +7 more
doaj   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

MDM2 negatively regulates the human telomerase RNA gene promoter [PDF]

, 2005
<b>Background:</b> We have previously demonstrated that NF-Y and Sp1 interact with the human telomerase RNA (hTR) promoter and play a central role in its regulation. We have also shown that pRB activates the hTR promoter, but the mechanism
Jiangqin Zhao (6471), Keith, W.N., Katrina Jackson (6473), Bilsland, A., Jackson, K., Keith W Nicol, Alan Bilsland (6472), Zhao, J., Zhao Jiangqin, Bilsland Alan, Jackson Katrina, W. Nicol Keith (261494), Alan Bilsland, Katrina Jackson, Jiangqin Zhao, W Nicol Keith   +15 more
core   +2 more sources

The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth

Neoplasia: An International Journal for Oncology Research, 2013
Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies.
Agni Christodoulidou, Christina Raftopoulou, Maria Chiourea, George K. Papaioannou, Hirotoshi Hoshiyama, Woodring E. Wright, Jerry W. Shay, Sarantis Gagos   +7 more
doaj   +1 more source