Results 81 to 90 of about 570,627 (165)
Telomere-independent functions of telomerase in nuclei, cytoplasm and mitochondria
Frontiers in Oncology, 2012 Telomerase canonical activity at telomeres prevents telomere shortening, allowing chromosome stability and cellular proliferation. To perform this task, the catalytic subunit (TERT) of the enzyme works as a reverse transcriptase together with the ...
Ilaria eChiodi, Chiara eMondello
doaj +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer [PDF]
Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization.
Kefah Mokbel +18 more
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Neoplasia: An International Journal for Oncology Research, 2001 We examined human telomerase reverse transcriptase (hTERT) protein distribution by immunohistochemistry in cultured cells and tissue sections. Cells with telomerase activity had nuclear positive signals whereas cells without telomerase activity did not ...
Eiso Hiyama +3 more
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The Journal of Physiology, EarlyView.Abstract figure legend Drug transporters P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) at the blood–brain barrier (BBB) protect the rapidly developing fetal brain. We investigated the role of microRNA‐145‐5p (miR‐145‐5p) microRNA (miRNA) in regulating these key transporters in primary human fetal brain endothelial cells in vitro. We
Phetcharawan Lye +5 more
wiley +1 more source
Telomerase Reverse Transcriptase Degradation via a Rationally Designed Covalent Proteolysis Targeting Chimera [PDF]
Expression of telomerase reverse transcriptase (TERT) is a hallmark of cancer, maintaining telomere length and integrity to enable replicative immortality.
Karl, Scheidt +3 more
core +2 more sources
Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.Dietary Echinacea purpurea (0.75%) alleviated oxidative stress (↓NO, ↓MDA) and selectively upregulated IL‐10 and IFN‐γ expression in heat‐stressed broilers at high altitude, shifting the cytokine balance toward an anti‐inflammatory state without affecting telomere length.
Shahab Bahadoran +2 more
wiley +1 more source
Control of human telomerase reverse transcriptase (hTERT) by NOD2.
, 2023 We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of the human telomerase reverse transcriptase (hTERT) by the NLR (nucleotide-binding oligomerization domain-like receptor) family ...
Shahan Mamoor
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Molecular Oncology, Volume 20, Issue 10, Page 2533-2566, October 2026.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Telomerase Induction in HPV Infection and Oncogenesis
Viruses, 2017 Telomerase extends the repetitive DNA at the ends of linear chromosomes, and it is normally active in stem cells. When expressed in somatic diploid cells, it can lead to cellular immortalization. Human papillomaviruses (HPVs) are associated with and high-
Rachel Katzenellenbogen
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