Results 101 to 110 of about 570,627 (165)

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

Is telomerase reactivation associated with the down-regulatoin of TGFβ receptor-II expression in human breast cancer? [PDF]

, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells. TGF beta (
Thomas, V, Abd E Elkak, Kefah Mokbel, Newbold, RF, Elkak Abd E, Mokbel Kefah, Newbold Robert F, Mokbel, K, Thomas Valene, Valene Thomas, Robert F Newbold, Elkak, AE   +11 more
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The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma

Immunology &Cell Biology, Volume 104, Issue 9, Page 881-895, October 2026.
(Left)The identification and elimination of tumour cells is enabled by the infiltration of functional innate and adaptive immune effectors into the TME, such as natural killer cells (NK cells) and cytotoxic T cells (CD8 T cells). Effective innate and adaptive immune responses facilitate immunological control of malignant outgrowth.
Sarah J. MacDonald, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Terence J. O'Brien, Rosalind L. Jeffree, Mastura Monif   +6 more
wiley   +1 more source

Recent progress in human telomerase structure and its therapeutic targeting

Frontiers in Molecular Biosciences
Most cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori, Abdulrahman Awad, Sarah Dhaiban, Mohammed Turki Alduhoori, Humayun Sharif, Abdulrahim Sajini   +5 more
doaj   +1 more source

Structure of telomerase reverse transcriptase (TERT).

, 2017
TERT contains a long NTE1 linked with a central catalytic RT domain and a short carboxy CTE, (TEN, yellow; TRBD, orange; fingers, gray; RT, blue; CTE, magenta) with conserved motifs in TRBD (T, green; CP, red) or RT motifs (IFD, cyan) or black.
Huy Tran (441825), Zhaowen Zhu (3617351), Warren N. Schmidt (3617348), M. Meleah Mathahs (3617354), Thomas O. Moninger (496889)   +4 more
core   +1 more source

Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells

Scientific Reports, 2017
Cisplatin is one of the most efficacious antimitotic drugs used in the treatment of a range of malignant tumors. However, treatment failures are common due to the development of chemoresistance.
Zhengpei Zhang, Ling Yu, Guo Dai, Kezhou Xia, Gaiwei Liu, Qi Song, Chunjie Tao, Tian Gao, Weichun Guo   +8 more
doaj   +1 more source

Telomerase Reverse Transcriptase Fragments And Uses Thereof [PDF]

, 2007
The Invention Provides Compositions Comprising Fragments Of Human Telomerase Reverse Transcriptase (Htert) Which Can Lead To Telomere Dysfunction In A Cell And Reduction Of Growth And Tumorigenicity In Cancer Cells.

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Ectopic expression of telomerase enhances osteopontin and osteocalcin expression during osteogenic differentiation of human mesenchymal stem cells from elder donors

Journal of Stem Cells and Regenerative Medicine, 2009
Age related bone loss is one of the most prevalent diseases in the elder population. The osteoblasts are the effectors cells of bone formation and regeneration.
Machado CB, Correa CR, Medrado GC, Leite MF, Goes AM   +4 more
doaj  

Telomerase reverse transcriptase fragments and uses thereof [PDF]

, 2003
The invention provides compositions comprising fragments of human telomerase reverse transcriptase (hTERT) which can lead to telomere dysfunction in a cell and reduction of growth and tumorigenicity in cancer cells.

core  

Do non-nucleoside reverse transcriptase inhibitors contribute to lipodystrophy? [PDF]

, 2005
Lipodystrophy complications, including lipoatrophy (pathological fat loss) and metabolic complications, have emerged as important long-term toxicities associated with antiretroviral therapy in the current era. The wealth of data that has accumulated over
Nolan, D.
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