Results 101 to 110 of about 28,516 (233)
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomerase is present in over 90% of tumour tissues and immortalized cells and is tightly regulated in most normal somatic cells.
Hasan, Rana
core
Telomerase Induction in HPV Infection and Oncogenesis
Viruses, 2017 Telomerase extends the repetitive DNA at the ends of linear chromosomes, and it is normally active in stem cells. When expressed in somatic diploid cells, it can lead to cellular immortalization. Human papillomaviruses (HPVs) are associated with and high-
Rachel Katzenellenbogen
doaj +1 more source
Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications
WIREs RNA, Volume 17, Issue 4, July/August 2026.Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus +5 more
wiley +1 more source
, 2003 Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells. TGF beta (
Thomas, V +11 more
core +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, Volume 20, Issue 6, Page 1420-1428, June 2026.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
The role of the cell attachment in the regulation of telomerase during keratinocyte differentiation
, 2010 PhDThe catalytic subunit of telomerase TERT has non-canonical functions, which are independent of telomere elongation and sometimes telomerase activity.
Cereser, Biancastella
core
Telomerase Reverse Transcriptase Fragments And Uses Thereof [PDF]
, 2007 The Invention Provides Compositions Comprising Fragments Of Human Telomerase Reverse Transcriptase (Htert) Which Can Lead To Telomere Dysfunction In A Cell And Reduction Of Growth And Tumorigenicity In Cancer Cells.
core
Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo [PDF]
, 2017 Telomerase action at telomeres is essential for the immortal phenotype of stem cells and the aberrant proliferative potential of cancer cells. Insufficient telomere maintenance can cause stem cell and tissue failure syndromes, while increased telomerase ...
Gill, Manraj S +6 more
core +1 more source
Advanced Science, Volume 13, Issue 35, 24 June 2026.ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs +4 more
wiley +1 more source
Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma
Biomedical Reports, 2015 Maintenance of telomere length is a critical hallmark of malignant transformation. While silenced in somatic cells, telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase, is frequently overexpressed in malignant cells thereby maintaining their telomere length.
Lindner, Sven +9 more
openaire +4 more sources