Results 121 to 130 of about 45,103 (233)

Evaluation of telomerase expression in chronic periodontitis

Indian Journal of Dental Research, 2010
Background : Human telomerase is a multi subunit ribonucleoprotein enzyme concerned with telomeric lengthening and homeostasis in man. This enzyme has been found to be elevated in inflammatory conditions like rheumatoid arthritis and silica injury lung ...
Balaji T, Vettriselvi V, Paul Solomon, Rao Suresh   +3 more
doaj  

A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. [PDF]

, 2018
Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. Here we perform an integrative analysis of 930 tumor whole genomes and matched transcriptomes, identifying a network of 193 ...
Bojorquez-Gomez, Ana, Carter, Hannah, Chen, Kevin, Farley, Emma K, Fraley, Stephanie I, Huang, Justin K, Ideker, Trey, Kreisberg, Jason F, Licon, Katherine, Melton, Collin, Olson, Katrina M, Sanchez, Kyle S, Shen, John Paul, Snyder, Michael, Velez, Daniel Ortiz, Xu, Guorong, Yu, Michael Ku, Zhang, Wei   +17 more
core   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, Volume 88, Issue 7, Page 1315-1323, June 2026.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Expression of hTERT mRNA in Anip973 and Anip973/NVB Cell Detected by Quantitative Real-time PCR

Chinese Journal of Lung Cancer, 2010
Background and objective Human telomerase reverse transcriptase is the catalytic subunit of telomerase, and its activity is correlated with cell’s sensitivity to chemotherapy.
Jingjing LIU, Shuying GUO, Gongyan CHEN
doaj  

The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism

Journal of Nucleic Acids, 2010
Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria.
Donna M. Gordon, Janine Hertzog Santos
doaj   +1 more source

The Outcome of Intracellular Selenomonas sputigena and its Impact on Gingival Keratinocytes

Molecular Oral Microbiology, Volume 41, Issue 3, Page 131-144, June 2026.
ABSTRACT Selenomonas sputigena is an understudied oral pathobiont associated with periodontitis and dental caries. We recently demonstrated that S. sputigena binds to gingival epithelial cells (GECs), where afterwards the bacterium causes robust in vitro pro‐inflammatory cytokine production and migration of monocytes and neutrophils.
Colin G. Hawkes, Travis J. Chiarelli, Doaa N. Abdallah, Grayson Way, Huiping Zhou, Jason A. Carlyon, Daniel P. Miller   +6 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, Volume 20, Issue 5, Page 1253-1269, May 2026.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Human Vault Nanoparticle Targeted Delivery of Antiretroviral Drugs to Inhibit Human Immunodeficiency Virus Type 1 Infection. [PDF]

, 2019
"Vaults" are ubiquitously expressed endogenous ribonucleoprotein nanoparticles with potential utility for targeted drug delivery. Here, we show that recombinant human vault nanoparticles are readily engulfed by certain key human peripheral blood ...
Anton, Peter A, Deming, Timothy, Elliott, Julie, Fulcher, Jennifer A, Ibarrondo, F Javier, Kickhoefer, Valerie A, Maynard, Heather D, Mrazek, Jan, Rome, Leonard H, Tamshen, Kyle, Wollenberg, Alexander L, Yang, Otto O   +11 more
core  

MicroRNA‐Mediated Regulation of Brain Aging Hallmarks: Implications for Neurodegeneration and Neural Recovery

Brain and Behavior, Volume 16, Issue 5, May 2026.
Hallmarks of brain aging regulated by microRNAs (miRNAs). This graphical abstract illustrates the central role of miRNAs in coordinating key biological processes associated with brain aging. miRNAs regulate multiple interconnected hallmarks, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis and impaired ...
Mustafa T. Ardah, Pareshkumar N. Patel, Omayma Salim Waleed, Jamuna K. V., Vandana Tripathi, L. Lakshmi, Rajashree Panigrahi, Manoj Kumar Mishra   +7 more
wiley   +1 more source