Results 121 to 130 of about 28,516 (233)

Relationship between hTERT levels and oxidative stress in epilepsy patients

Epilepsia Open, Volume 11, Issue 3, Page 752-763, June 2026.
Abstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Muhammed Mehdi Üremiş, Deniz Tuncel Berktaş, Nuray Üremiş, Fatma İnanç Tolun   +3 more
wiley   +1 more source

Conditional immortalization of human B cells by CD40 ligation [PDF]

, 2008
It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro.
Mayr, C., Caroline Zentz, Reinhard Zeidler, Hammerschmidt, W., Wolfgang Hammerschmidt, Wiesner, Martina, Wimmer, Rainer, Wiesner, M., Christine Mayr, Hammerschmidt, Wolfgang, Zentz Caroline, Zentz, C., Moosmann, A., Zeidler, Reinhard, Wiesner Martina, Moosmann Andreas, Andreas Moosmann, Mayr Christine, Wimmer, R., Wimmer Rainer, Zentz, Caroline, Hammerschmidt Wolfgang, Mayr, Christine, Martina Wiesner, Moosmann, Andreas, Rainer Wimmer, Zeidler Reinhard, Zeidler, R.   +27 more
core   +1 more source

Recent progress in human telomerase structure and its therapeutic targeting

Frontiers in Molecular Biosciences
Most cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori, Abdulrahman Awad, Sarah Dhaiban, Mohammed Turki Alduhoori, Humayun Sharif, Abdulrahim Sajini   +5 more
doaj   +1 more source

Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase

, 2000
Replicative senescence of T cells is correlated with erosion of telomere ends. Telomerase plays a key role in maintaining telomere length. Therefore, it is thought that telomerase regulates the life span of T cells.
Ruizendaal, J. J., Snijders, P. J., Spits, H., Walboomers, J. M., Hooijberg, E., Kueter, E. W.   +5 more
core   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

Structural studies of three enzymes: telomerase, the methyltransferase CobJ and pectate lyase

, 2011
PhDThis thesis investigates the structure and function of three enzymes of biotechnological and biomedical interest: telomerase from Caenorhabtidis elegans, pectate lyase from Bacillus subtilis and the methyltransferase CobJ from Rhodobacter capsulatus.
To, Teng Teng
core  

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Supplementary Data from Deregulated GSK3 Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase

, 2009
Supplementary Data from Deregulated GSK3 Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and ...
Kazuyuki Kawakami (280843), Mingji Jin (12101289), Takeo Shimasaki (280834), Satoru Kyo (4988318), Wei Mai (9637471), Katsuyoshi Miyashita (14975955), Abbas Shakoori (420480), Kenji Yokoi (552570), Toshinari Minamoto (280844), Yoshiharu Motoo (280842)   +9 more
core   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Reverse transcriptase inhibitors suppress telomerase function and induce senescence-like processes in cultured mouse fibroblasts

, 1996
Spontaneous transformation of mouse embryonic fibroblasts in the presence of the reverse transcriptase inhibitors azidothymidine and carbovir led to the formation of telomerase-free clones.
Alexander A. Krayevsky, Yegorov, Yegor E., Nadezda L. Bolsheva, Akimov, Sergei S., Alexander V. Zelenin, Bolsheva, Nadezda L., Sergei S. Akimov, Yegor E. Yegorov, Zelenin, Alexander V., Chernov, Dmitry N., Dmitry N. Chernov, Krayevsky, Alexander A.   +11 more
core   +1 more source