Diverse regulatory manners of human telomerase reverse transcriptase [PDF]
Cell Communication and Signaling, 2019 Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer cell stemness maintaining, cell proliferation,
Meng-Meng Jie +9 more
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Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes [PDF]
Biomedicines, 2021 Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase reverse transcriptase) pre-mRNA strongly regulates telomerase activity.
Anna A. Plyasova, Dmitry D. Zhdanov
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Cancer-associated TERT promoter mutations abrogate telomerase silencing [PDF]
eLife, 2015 Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established.
Kunitoshi Chiba +5 more
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AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase. [PDF]
PLoS ONE, 2018 The expression of hTERT in tumor cells contributes to oncogenic transformation by promoting immortalization. For this reason, hTERT is one of the major targets for cancer therapy, and an efficient method to downregulate hTERT expression is required for ...
Daum Jo +6 more
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Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines [PDF]
Biomedical Journal, 2019 Background: The anterior-cruciate-ligament (ACL) contains mesenchymal stem cells (ACL-MSCs), suggesting the feasibility of regenerative treatments of this tissue.
Patrick Prager +5 more
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Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer [PDF]
Journal of Biomedical Science, 2018 Background Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation.
Ricardo Leão +5 more
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Research progress on mitochondrial translocation of human telomerase reverse transcriptase [PDF]
Jichu yixue yu linchuang, 2021 Telomerase reverse transcriptase is a subunit of telomerase, which plays an important role in activating telomerase and regulating cell cycle. Human telomerase reverse transcriptase(hTERT) is mainly expressed in germ cells, embryonic stem cells and tumor
HU Wei-kai, LIU Rui-xia, YIN Cheng-hong
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Future Journal of Pharmaceutical Sciences, 2021 Background Telomerase reverse transcriptase (TERT) and human telomeric G-quadruplex DNA are amongst the favorable target for researchers to discover novel and more effective anticancer agents.
R. D. Jawarkar +6 more
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Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer
Balkan Medical Journal, 2017 Aims: To investigate the changes in mRNA expression levels of telomerase-related significant proteins in several types of cancer. Methods: Human telomerase reverse transcriptase, pontin, reptin and dyskerin expressions were measured in normal and tumour
Emel Çalışkan Can +5 more
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CDK1 dependent phosphorylation of hTERT contributes to cancer progression
Nature Communications, 2020 Regulated telomerase reverse transcriptase (hTERT) activity is common in human tumors. Here, the authors show that hTERT is phosphorylated by CDK1 and that this event is necessary for hTERT-mediated RNA dependent RNA polymerase activity but not for ...
Mami Yasukawa +18 more
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