Results 11 to 20 of about 24,740 (216)

Usefulness of Immunological Detection of the Human Telomerase Reverse Transcriptase

Cellular Oncology, 2005
Objective: Recent years have seen a considerable wealth of studies conducted on the potential usefulness of telomerase determination in diagnosis, prognosis and targeted cancer therapy.
Annalisa Volpi, Sara Bravaccini, Laura Medri, Serenella Cerasoli, Michele Gaudio, Dino Amadori   +5 more
doaj   +4 more sources

Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo. [PDF]

PLoS ONE, 2009
BACKGROUND:Telomerase is a reverse transcriptase that maintains the telomeres of linear chromosomes and preserves genomic integrity. The core components are a catalytic protein subunit, the telomerase reverse transcriptase (TERT), and an RNA subunit, the
Haley D M Wyatt, Allison R Tsang, Deirdre A Lobb, Tara L Beattie   +3 more
doaj   +5 more sources

Human telomerase reverse transcriptase expression in ovarian tumors

Indian Journal of Pathology and Microbiology, 2012
Background : Ovarian cancer is the 6 th most common cancer among women. In ovarian tumors, the borderline category is not well defined due to the difficulty in assessing stromal invasion. The World Health Organization (WHO) defined it as tumor that lacks
Awadh Ali Makhashen Maraei, Ahmad Zailani Hatta, Mohd Sidik Shiran, Geok Chin Tan   +3 more
doaj   +3 more sources

Regulation of the human telomerase reverse transcriptase gene [PDF]

Oncogene, 2002
Most somatic human cells lack telomerase activity because they do not express the telomerase reverse transcriptase (hTERT) gene. Conversely, most cancer cells express hTERT and are telomerase positive. For most tumors it is not clear whether hTERT expression is due to their origin from telomerase positive stem cells or to reactivation of the gene ...
Anne-Lyse, Ducrest, Henrietta, Szutorisz, Joachim, Lingner, Markus, Nabholz   +3 more
core   +5 more sources

Functional Multimerization of the Human Telomerase Reverse Transcriptase [PDF]

Molecular and Cellular Biology, 2001
The telomerase enzyme exists as a large complex (approximately 1,000 kDa) in mammals and at minimum is composed of the telomerase RNA and the catalytic subunit telomerase reverse transcriptase (TERT). In Saccharomyces cerevisiae, telomerase appears to function as an interdependent dimer or multimer in vivo (J. Prescott and E. H.
T L, Beattie, W, Zhou, M O, Robinson, L, Harrington   +3 more
openaire   +3 more sources

Human Specific Regulation of the Telomerase Reverse Transcriptase Gene [PDF]

Genes, 2016
Telomerase, regulated primarily by the transcription of its catalytic subunit telomerase reverse transcriptase (TERT), is critical for controlling cell proliferation and tissue homeostasis by maintaining telomere length. Although there is a high conservation between human and mouse TERT genes, the regulation of their transcription is significantly ...
Zhang, Fan, Cheng, De, Wang, Shuwen, Zhu, Jiyue   +3 more
openaire   +5 more sources

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria [PDF]

Nucleic Acids Research, 2011
Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show, using multiple approaches, that mammalian TERT is mitochondrial, co-purifying with mitochondrial nucleoids and tRNAs.
Sharma, Nilesh K, Reyes, Aurelio, Green, Paula, Caron, Matthieu J, Bonini, Marcelo G, Gordon, Donna M, Holt, Ian J, Santos, Janine Hertzog   +7 more
openaire   +4 more sources

Control of human telomerase reverse transcriptase (hTERT) by NOD2.

, 2023
We provide evidence here from overexpression-based gain-of-function studies in human cells (1, 2) which demonstrate control of the human telomerase reverse transcriptase (hTERT) by the NLR (nucleotide-binding oligomerization domain-like receptor) family protein NOD2.
Shahan Mamoor
openaire   +2 more sources

Is telomerase reactivation associated with the down-regulation of TGF β receptor-II expression in human breast cancer?

Cancer Cell International, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells.
Thomas Valene, Newbold Robert F, Elkak Abd E, Mokbel Kefah   +3 more
doaj   +2 more sources

Influence of Human Telomerase Reverse Transcriptase Mutation on the Aggressiveness and Recurrence in Meningiomas. [PDF]

Cureus, 2021
 Over 200 human telomerase reverse transcriptase (hTERT) polymorphism combinations have been implicated in the development of cancer. This study aimed to evaluate hTERT mutations in meningioma tissue and its association with meningioma.A total of 90 patients who underwent surgery between 2006 and 2015 and were histopathologically diagnosed with ...
Sahin B, Katar S, Şahin SA, Çevik S, Evran S, Baran O, Tanık C, Adılay HU, Yılmaz A.   +8 more
europepmc   +5 more sources