Results 11 to 20 of about 40,478 (236)

Human telomerase reverse transcriptase expression in ovarian tumors

Indian Journal of Pathology and Microbiology, 2012
Background : Ovarian cancer is the 6 th most common cancer among women. In ovarian tumors, the borderline category is not well defined due to the difficulty in assessing stromal invasion. The World Health Organization (WHO) defined it as tumor that lacks
Awadh Ali Makhashen Maraei, Ahmad Zailani Hatta, Mohd Sidik Shiran, Geok Chin Tan   +3 more
doaj   +3 more sources

Human Telomerase Activation Requires Two Independent Interactions between Telomerase RNA and Telomerase Reverse Transcriptase [PDF]

Molecular Cell, 2000
Inhibition or activation of the reverse transcriptase telomerase can profoundly affect the proliferative capacity of normal cells and cancers. Here, we elucidate structural requirements for function of the essential RNA component of human telomerase, hTR.
Mitchell, James R., Collins, Kathleen
openaire   +4 more sources

Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. [PDF]

PLoS ONE, 2013
The Hedgehog (HH) signaling pathway is critical for normal embryonic development, tissue patterning and cell differentiation. Aberrant HH signaling is involved in multiple human cancers.
Tapati Mazumdar, Ranjodh Sandhu, Maha Qadan, Jennifer DeVecchio, Victoria Magloire, Akwasi Agyeman, Bibo Li, Janet A Houghton   +7 more
doaj   +4 more sources

Usefulness of Immunological Detection of the Human Telomerase Reverse Transcriptase

Cellular Oncology, 2005
Objective: Recent years have seen a considerable wealth of studies conducted on the potential usefulness of telomerase determination in diagnosis, prognosis and targeted cancer therapy.
Annalisa Volpi, Sara Bravaccini, Laura Medri, Serenella Cerasoli, Michele Gaudio, Dino Amadori   +5 more
doaj   +3 more sources

Regulation of the human telomerase reverse transcriptase gene [PDF]

Oncogene, 2002
Most somatic human cells lack telomerase activity because they do not express the telomerase reverse transcriptase (hTERT) gene. Conversely, most cancer cells express hTERT and are telomerase positive. For most tumors it is not clear whether hTERT expression is due to their origin from telomerase positive stem cells or to reactivation of the gene ...
Anne-Lyse, Ducrest, Henrietta, Szutorisz, Joachim, Lingner, Markus, Nabholz   +3 more
openaire   +4 more sources

Functional Multimerization of the Human Telomerase Reverse Transcriptase [PDF]

Molecular and Cellular Biology, 2001
The telomerase enzyme exists as a large complex (approximately 1,000 kDa) in mammals and at minimum is composed of the telomerase RNA and the catalytic subunit telomerase reverse transcriptase (TERT). In Saccharomyces cerevisiae, telomerase appears to function as an interdependent dimer or multimer in vivo (J. Prescott and E. H.
T L, Beattie, W, Zhou, M O, Robinson, L, Harrington   +3 more
openaire   +2 more sources

Transcriptional regulation of the human telomerase reverse transcriptase [PDF]

Transcription, 2010
hTERT and NFAT were thought until recently to belong to separate metabolic compartments. The involvement of NFAT in the induction of hTERT transcription suggested by hTERT expression variations during lymphocyte stimulation and immunosuppressive treatments explains the link between hTERT expression and cell stimulation and offers new insights for ...
Amel, Chebel, Martine, Ffrench
openaire   +2 more sources

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Human Specific Regulation of the Telomerase Reverse Transcriptase Gene [PDF]

Genes, 2016
Telomerase, regulated primarily by the transcription of its catalytic subunit telomerase reverse transcriptase (TERT), is critical for controlling cell proliferation and tissue homeostasis by maintaining telomere length. Although there is a high conservation between human and mouse TERT genes, the regulation of their transcription is significantly ...
Zhang, Fan, Cheng, De, Wang, Shuwen, Zhu, Jiyue   +3 more
openaire   +3 more sources

CHIP Promotes Human Telomerase Reverse Transcriptase Degradation and Negatively Regulates Telomerase Activity [PDF]

Journal of Biological Chemistry, 2010
The maintenance of eukaryotic telomeres requires telomerase, which is minimally composed of a telomerase reverse transcriptase (TERT) and an associated RNA component. Telomerase activity is tightly regulated by expression of human (h) TERT at both the transcriptional and post-translational levels.
Ji Hoon, Lee, Prabhat, Khadka, Seung Han, Baek, In Kwon, Chung   +3 more
openaire   +2 more sources