Results 41 to 50 of about 40,478 (236)

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms [PDF]

, 2014
Cancer cells depend on transcription of telomerase reverse transcriptase (TERT). Many transcription factors affect TERT, though regulation occurs in context of a broader network. Network effects on telomerase regulation have not been investigated, though
A Agrawal, A De Cian, A Goltsov, A Graudenzi, A Schonthal, A Subramanian, A Tapias, A Tapias, A von Kriegsheim, A Wuensche, AE Bilsland, AE Bilsland, AE Bilsland, AE Bilsland, Alan E. Bilsland, B Tang, C Jiang, C Lawless, C Torres-Sosa, CJ Anderson, Claire J. Cairney, D Hanahan, D Machado, D Xu, DE Nelson, DG Johnson, DH Crouch, DJ Billingsley, DL Crowe, DR White, E Yang, EJ Black, F Gizard, FW Huang, G Niu, G Wrobel, H Yuan, J Cho, J Grefenstette, J Won, J Zhao, JN Davis, Jon Roffey, JS Ho, K Cho, K Jiang, K Lafferty-Whyte, K Lafferty-Whyte, K Lafferty-Whyte, K Ookawa, K Thalmeier, K Willadsen, Katrina Stevenson, KI Zeller, KJ Wu, KM Ryan, L Chen, L Durant, L Konnikova, LA Bell, LC Freeman, LE Sivak, LG Wooten-Blanks, LI Chen, M Choi, M Daniel, M Kohl, M Nicolas, M Takakura, N Arkus, N Benson, N Kley, OE Akman, OW Rokhlin, P Angel, PJ Killela, PM Neilsen, Q Wang, R Duan, R Schlatter, R Wilds, RT Sitaram, S Horn, S Hossain, S Huang, S Kauffman, S Kyo, S Mangan, S Oh, Satoru Miyano, SM Mac, SP Hsu, Stacey Hoare, SY Lin, T Kanaya, T Maki-Marttunen, T Sengupta, TG Oliver, TH Kim, U Moehren, V Anest, V Batagelj, VJ Gnanapragasam, VK Mootha, W. Nicol Keith, WB Lee, X Chen, Y Xiao, Y Xing, Y Yao, Yu Liu   +110 more
core   +3 more sources

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter. [PDF]

, 2016
Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success. Previously we showed that the Chinese herbal medicine Tianshengyuan-1 (TSY-1), an agent used to treat bone marrow deficiency, has a ...
Chow, Michelle, Jin, Yusheng, Li, Yawei, Qin, Xiaotian, Rao, Jianyu, Santiskulvong, Chintda, Vu, Victor, Yu, Weibo, Zeng, Gang, Zhang, Zuofeng   +9 more
core   +2 more sources

Effective siRNA targets screening for human telomerase reverse transcriptase

World Journal of Gastroenterology, 2005
To study the inhibitory effects of siRNAs targeting different hTERT sequences and to screen the effective siRNA sequence.Five double-stranded siRNAs targeting coding and non-coding regions of hTERT gene were designed and synthesized by T7 transcription system in vitro. siRNA4 sequence was screened by full length gene targeting technique and the rest of
Yun, Xia, Ru-Xian, Lin, Su-Jun, Zheng, Ying, Yang, Xiao-Chen, Bo, Dao-Yin, Zhu, Sheng-Qi, Wang   +6 more
openaire   +2 more sources

The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth

Neoplasia: An International Journal for Oncology Research, 2013
Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies.
Agni Christodoulidou, Christina Raftopoulou, Maria Chiourea, George K. Papaioannou, Hirotoshi Hoshiyama, Woodring E. Wright, Jerry W. Shay, Sarantis Gagos   +7 more
doaj   +1 more source

AZT exerts its antitumoral effect by telomeric and non-telomeric effects in a mammary adenocarcinoma model [PDF]

, 2016
Limitless replicative potential is one of the hallmarks of cancer that is mainly due to the activity of telomerase. This holoenzyme maintains telomere length, adding TTAGGG repetitions at the end of chromosomes in each cell division.
Armando, Romina Gabriela, Gomez, Daniel Eduardo, Gomez, Daniel Eduardo   +2 more
core   +1 more source

P. berghei telomerase subunit TERT is essential for parasite survival [PDF]

, 2014
Telomeres define the ends of chromosomes protecting eukaryotic cells from chromosome instability and eventual cell death. The complex regulation of telomeres involves various proteins including telomerase, which is a specialized ribonucleoprotein ...
Janse, Chris J., Ramesar, Jai, Religa, Agnieszka, Scherf, Artur, Waters, Andrew P.   +4 more
core   +7 more sources

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Neoplasia: An International Journal for Oncology Research, 2000
Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence.
Xiaoming Yi, Dennis M. White, Dara L. Aisner, Joseph A. Baur, Woodring E. Wright, Jerry W. Shay   +5 more
doaj   +1 more source

Many Disease-Associated Variants of hTERT Retain High Telomerase Enzymatic Activity [PDF]

, 2013
Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer.
Campbell, Kristina, Cech, Thomas R, Crary, Sharon M, Fioravanti, Matthew Jesse, Zaug, Arthur J   +4 more
core   +5 more sources

Cellular distribution of telomerase reverse transcriptase in human hepatocellular carcinoma [PDF]

Journal of Gastroenterology and Hepatology, 2003
AbstractBackground and Aim:  Telomerase is the enzyme that synthesizes telomeric DNA, and the activation of telomerase is closely related to cellular immortality. Telomerase activity has been reported in many human cancer tissues and is regulated by the expression of human telomerase reverse transcriptase (hTERT).
Toru, Onishi, Kazuhiro, Nouso, Toshihiro, Higashi, Nobuyuki, Toshikuni, Harushige, Nakatsukasa, Yoshiyuki, Kobayashi, Masayuki, Uemura, Eiichiro, Yumoto, Keishi, Fujiwara, Shuichiro, Sato, Shinichiro, Nakamura, Junko, Yokoyama, Tadashi, Hanafusa, Yasushi, Shiratori   +13 more
openaire   +2 more sources

Alternative Splicing of Human Telomerase Reverse Transcriptase May Not Be Involved in Telomerase Regulation During all-trans-Retinoic Acid-Induced HL-60 Cell Differentiation

Journal of Pharmacological Sciences, 2004
Alternative splicing of the human telomerase reverse transcriptase subunit (hTERT) suppresses telomerase activity during the development of human fetal kidney cells into mature cells.
Wei-Jun Liu, Yong-Wei Zhang, Zhi-Xiang Zhang, Jian Ding   +3 more
doaj   +1 more source