Results 41 to 50 of about 24,740 (216)
The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies
Balkan Medical Journal, 2013 Background: Telomeres are essential for the function and stability of eukaryotic chromosomes. Telomerase consists of three subunits: human telomerase reverse transcriptase (hTERT), human telomerase RNA (hTR), and telomerase protein 1 (TP1).
İlhami Gül +4 more
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Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. [PDF]
Genes (Basel), 2016 Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%–90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely.
Ramlee MK, Wang J, Toh WX, Li S.
europepmc +5 more sources
Cellular distribution of telomerase reverse transcriptase in human hepatocellular carcinoma [PDF]
Journal of Gastroenterology and Hepatology, 2003 AbstractBackground and Aim: Telomerase is the enzyme that synthesizes telomeric DNA, and the activation of telomerase is closely related to cellular immortality. Telomerase activity has been reported in many human cancer tissues and is regulated by the expression of human telomerase reverse transcriptase (hTERT).
Toru, Onishi +13 more
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The mRNA expression of hTERT in human breast carcinomas correlates with VEGF expression
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalisation.
Newbold, RF, Kirkpatrick, KL, Mokbel, K
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Life, 2021 Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin ...
Hueng-Chuen Fan +7 more
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Conditional immortalization of human B cells by CD40 ligation [PDF]
, 2008 It is generally assumed that human differentiated cells have a limited life-span and proliferation capacity in vivo, and that genetic modifications are a prerequisite for their immortalization in vitro.
Mayr, C. +27 more
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Telomerase: An exploration toward the end of cancer
Indian Journal of Dental Research, 2017 Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells.
Deepika Bablani Popli +2 more
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Frontiers in Cell and Developmental Biology, 2023 Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), which ...
Justin A. Davis +8 more
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Telomeres in Evolution and Development from Biosemiotic Perspective
, 2007 Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
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The association between telomerase activity and expression of its RNA component (hTR) in breast cancer patients: the importance of DNase treatment [PDF]
Telomerase is a ribonucleoprotein enzyme that compensates for the telomere length shortening which occurs during the cell cycle. Telomerase activity has been detected in most tumours but not in somatic cells.
حسینی اصل, سید سعید +5 more
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