Results 31 to 40 of about 23,184 (172)

Alternative Splicing of Human Telomerase Reverse Transcriptase May Not Be Involved in Telomerase Regulation During all-trans-Retinoic Acid-Induced HL-60 Cell Differentiation

Journal of Pharmacological Sciences, 2004
Alternative splicing of the human telomerase reverse transcriptase subunit (hTERT) suppresses telomerase activity during the development of human fetal kidney cells into mature cells.
Wei-Jun Liu, Yong-Wei Zhang, Zhi-Xiang Zhang, Jian Ding   +3 more
doaj   +1 more source

The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies

Balkan Medical Journal, 2013
Background: Telomeres are essential for the function and stability of eukaryotic chromosomes. Telomerase consists of three subunits: human telomerase reverse transcriptase (hTERT), human telomerase RNA (hTR), and telomerase protein 1 (TP1).
İlhami Gül, Özgür Dündar, Levent Tütüncü, Serkan Bodur, Yusuf Tunca   +4 more
doaj   +1 more source

TAK1 represses transcription of the human telomerase reverse transcriptase gene [PDF]

Oncogene, 2007
In human cells, telomerase activity is tightly regulated by the expression of its catalytic subunit, namely, the human telomerase reverse transcriptase (hTERT). However, the molecular mechanisms involved in the regulation of hTERT expression have not been completely clarified.
T, Fujiki, T, Miura, M, Maura, H, Shiraishi, S, Nishimura, Y, Imada, N, Uehara, K, Tashiro, S, Shirahata, Y, Katakura   +9 more
openaire   +2 more sources

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria [PDF]

Nucleic Acids Research, 2011
Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show, using multiple approaches, that mammalian TERT is mitochondrial, co-purifying with mitochondrial nucleoids and tRNAs.
Sharma, Nilesh K, Reyes, Aurelio, Green, Paula, Caron, Matthieu J, Bonini, Marcelo G, Gordon, Donna M, Holt, Ian J, Santos, Janine Hertzog   +7 more
openaire   +2 more sources

Telomerase: An exploration toward the end of cancer

Indian Journal of Dental Research, 2017
Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells.
Deepika Bablani Popli, Keya Sircar, Aman Chowdhry   +2 more
doaj   +1 more source

Telomeres and Cancer

Life, 2021
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin ...
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn   +7 more
doaj   +1 more source

Proteomic identification of proteins differentially expressed following overexpression of hTERT (human telomerase reverse transcriptase) in cancer cells. [PDF]

PLoS ONE, 2017
Reverse transcriptase activity of telomerase adds telomeric repeat sequences at extreme ends of the newly replicated chromosome in actively dividing cells.
Rishi Kumar Jaiswal, Pramod Kumar, Amod Sharma, Deepak Kumar Mishra, Pramod Kumar Yadava   +4 more
doaj   +1 more source

Proteomic analysis defines the interactome of telomerase in the protozoan parasite, Trypanosoma brucei

Frontiers in Cell and Developmental Biology, 2023
Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), which ...
Justin A. Davis, Andres V. Reyes, Nitika, Arpita Saha, Donald J. Wolfgeher, Shou-Ling Xu, Andrew W. Truman, Bibo Li, Kausik Chakrabarti   +8 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Cellular distribution of telomerase reverse transcriptase in human hepatocellular carcinoma [PDF]

Journal of Gastroenterology and Hepatology, 2003
AbstractBackground and Aim:  Telomerase is the enzyme that synthesizes telomeric DNA, and the activation of telomerase is closely related to cellular immortality. Telomerase activity has been reported in many human cancer tissues and is regulated by the expression of human telomerase reverse transcriptase (hTERT).
Toru, Onishi, Kazuhiro, Nouso, Toshihiro, Higashi, Nobuyuki, Toshikuni, Harushige, Nakatsukasa, Yoshiyuki, Kobayashi, Masayuki, Uemura, Eiichiro, Yumoto, Keishi, Fujiwara, Shuichiro, Sato, Shinichiro, Nakamura, Junko, Yokoyama, Tadashi, Hanafusa, Yasushi, Shiratori   +13 more
openaire   +2 more sources