PLoS ONE, 2012 Telomerase is a specialized reverse transcriptase responsible for the de novo synthesis of telomeric DNA repeats. In addition to its established reverse transcriptase and terminal transferase activities, recent reports have revealed unexpected cellular ...
Kyle R Hukezalie +3 more
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Single cell measurement of telomerase expression and splicing using microfluidic emulsion cultures. [PDF]
, 2014 Telomerase is a reverse transcriptase that maintains telomeres on the ends of chromosomes, allowing rapidly dividing cells to proliferate while avoiding senescence and apoptosis.
Hart, Kristina +2 more
core +1 more source
Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma
World Journal of Gastroenterology, 2006 To study the activity of telomerase and the expression of human telomerase reverse transcriptase (hTERT) in colorectal carcinoma and its adjacent tissues, normal mucosa and adenomatoid polyp, and to evaluate their relation with carcinogenesis and progression of colorectal carcinoma.Telomerase activity and hTERT expression were determined in 30 samples ...
Jian-Lun, Liu +2 more
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KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway. [PDF]
, 2017 Melanoma is an aggressive cutaneous malignancy, illuminating the exact mechanisms and finding novel therapeutic targets are urgently needed. In this study, we identified KMT2A as a potential target, which promoted the growth of human melanoma cells ...
Chen, Miao +18 more
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Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link? [PDF]
, 2020 Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress.
Erusalimsky, Jorge
core +1 more source
How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
Biomedicines, 2022 Telomerase RNA has been uncovered as a component of the telomerase enzyme, which acts as a reverse transcriptase and maintains the length of telomeres in proliferated eukaryotic cells.
Maria Rubtsova, Olga Dontsova
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Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]
, 2018 The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea +4 more
core +1 more source
Modulation of human telomerase reverse transcriptase in hepatocellular carcinoma
World Journal of Gastroenterology, 2004 Most cancer cells acquire immortal capability by telomerase activation. The human telomerase reverse transcriptase gene (hTERT) is considered to be the major determinant of the enzymatic activity of human telomerase, and the hTERT promoter contains several c-Myc binding sites that mediate hTERT transcriptional activation.
Cheng-Jueng, Chen +7 more
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Cytotoxic T cell immunity against telomerase reverse transcriptase in humans [PDF]
Proceedings of the National Academy of Sciences, 2000 Telomerase is a ribonucleoprotein enzyme which has been linked to malignant transformation in human cells. Telomerase activity is increased in the vast majority of human tumors, making its gene product the first molecule common to all human tumors.
B, Minev +5 more
openaire +2 more sources
Prognostic Relevance of hTERT mRNA Expression in Ductal Adenocarcinoma of the Pancreas
Neoplasia: An International Journal for Oncology Research, 2008 Telomerase is thought to play an essential role in tumorigenesis and progression. Its activity is directly correlated with the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT).
Lukasz-Filip Grochola +7 more
doaj +1 more source