Results 51 to 60 of about 40,478 (236)
The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies
Balkan Medical Journal, 2013 Background: Telomeres are essential for the function and stability of eukaryotic chromosomes. Telomerase consists of three subunits: human telomerase reverse transcriptase (hTERT), human telomerase RNA (hTR), and telomerase protein 1 (TP1).
İlhami Gül +4 more
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Life, 2021 Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin ...
Hueng-Chuen Fan +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Telomerase is a ribonucleoprotein enzyme responsible for maintaining the telomeric end of the chromosome. The telomerase enzyme requires two main components to function: the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), which ...
Justin A. Davis +8 more
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Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. [PDF]
Genes (Basel), 2016 Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%–90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely.
Ramlee MK, Wang J, Toh WX, Li S.
europepmc +5 more sources
Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells [PDF]
, 2016 open7siBesides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions.
Celeghin, Andrea +6 more
core +1 more source
Telomerase: An exploration toward the end of cancer
Indian Journal of Dental Research, 2017 Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells.
Deepika Bablani Popli +2 more
doaj +1 more source
Proteomic identification of proteins differentially expressed following overexpression of hTERT (human telomerase reverse transcriptase) in cancer cells. [PDF]
PLoS ONE, 2017 Reverse transcriptase activity of telomerase adds telomeric repeat sequences at extreme ends of the newly replicated chromosome in actively dividing cells.
Rishi Kumar Jaiswal +4 more
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Telomerase Induction in HPV Infection and Oncogenesis
Viruses, 2017 Telomerase extends the repetitive DNA at the ends of linear chromosomes, and it is normally active in stem cells. When expressed in somatic diploid cells, it can lead to cellular immortalization. Human papillomaviruses (HPVs) are associated with and high-
Rachel Katzenellenbogen
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Development and characterization of a new human hepatic cell line [PDF]
, 2015 The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert +6 more
core +3 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source