Results 71 to 80 of about 40,478 (236)

Structures of nucleotide-bound human telomerase at several steps of its telomeric DNA repeat addition cycle

Nature Communications
In most eukaryotes, the reverse transcriptase telomerase counteracts telomere shortening by processively adding telomeric DNA repeat sequences to chromosome ends.
Sebastian Balch, Elsa Franco-Echevarría, George E. Ghanim, Rachael C. Kretsch, Rhiju Das, Thi Hoang Duong Nguyen   +5 more
doaj   +1 more source

Telomerase promoter mutations in human immunodeficiency virus-related conjunctiva neoplasia

Journal of Translational Medicine, 2018
Background Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection.
Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source

Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo. [PDF]

PLoS ONE, 2009
BACKGROUND:Telomerase is a reverse transcriptase that maintains the telomeres of linear chromosomes and preserves genomic integrity. The core components are a catalytic protein subunit, the telomerase reverse transcriptase (TERT), and an RNA subunit, the
Haley D M Wyatt, Allison R Tsang, Deirdre A Lobb, Tara L Beattie   +3 more
doaj   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Immunohistochemical Detection of Telomerase (hTERT) Protein in Human Cancer Tissues and a Subset of Cells in Normal Tissues

Neoplasia: An International Journal for Oncology Research, 2001
We examined human telomerase reverse transcriptase (hTERT) protein distribution by immunohistochemistry in cultured cells and tissue sections. Cells with telomerase activity had nuclear positive signals whereas cells without telomerase activity did not ...
Eiso Hiyama, Keiko Hiyama, Takashi Yokoyama, Jerry W. Shay   +3 more
doaj   +1 more source

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, EarlyView.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues [PDF]

Oncogene, 2000
Although telomerase activity in hepatocellular carcinoma (HCC) increases in accordance with degree of histological undifferentiation, it is unknown whether the level of telomerase activity in HCC reflects of the degree of activity in individual cells or the frequency of telomerase-positive HCC cells.
G.Kajiyama., Y.Kawakami, M.Kitamoto, T.Nakanishi, W.Yasui, E.Tahara, J.Nakayama, F.Ishikawa, H.Tahara, T.Ide   +9 more
openaire   +2 more sources

Immunoexpression of human telomerase reverse transcriptase in fibroepithelial tumors of the breast

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2023
Background: Phyllodes tumors and fibroadenomas are groups of fibroepithelial tumors in the breast that have different therapeutic approaches due to their rate of progression.
Fairuz Fairuz, Humaryanto Humaryanto
doaj   +1 more source

Targeted Detection of G-Quadruplexes in Cellular RNAs. [PDF]

, 2015
The G-quadruplex (G4) is a non-canonical nucleic acid structure which regulates important cellular processes. RNA G4s have recently been shown to exist in human cells and be biologically significant.
Balasubramanian, Shankar, Kwok, Chun Kit
core   +2 more sources

Long Noncoding RNA H19 Mediates STAT3‐Dependent Activation of Keratinocytes and Fibroblasts in Systemic Sclerosis Skin

Arthritis &Rheumatology, EarlyView.
Objective Dermal systemic sclerosis (SSc) fibroblasts and their exosomes can activate keratinocytes in SSc, with long noncoding RNA (lncRNA) H19 highlighted as the most up‐regulated RNA in their cargo compared with healthy controls (HCs). The role of H19 in SSc pathogenesis has never been investigated.
Begoña Caballero‐Ruiz, Christopher W. Wasson, Rebecca L. Ross, Francesco Del Galdo   +3 more
wiley   +1 more source