Results 71 to 80 of about 23,184 (172)

Telomerase reverse transcriptase mediated immortalization of human bone marrow stromal cells

Brazilian Archives of Biology and Technology, 2014
Primary human bone marrow stromal cells (hMSCs) were transfected with human telomerase reverse transcriptase (hTERT) gene with lipofection method.
Yong Teng, YunYu Hu, Xu Sheng Li, Zhen Wang, Rui Wang   +4 more
doaj   +1 more source

Improved Method for Obtaining Patient‐Derived Glioblastoma Organoid and Primary Cells: A Generic and Simplified Approach for Intracranial Tumor With Minimized Input

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
An improved and simplified method enables the generation of primary tumor cells and tumoroids from the same tissue sample with minimal input, applicable universally to both intracranial and spinal tumors. Comparative analysis of drug screening results with patient follow‐up data allows for the assessment of individual drug sensitivity.
Siyuan Wang, Zhonggang Shi, Chihao Zhu, Dawei Dai, Xi Yang, Zhiyi Zhou, Qianying Qiu, Wenhua Sun, Yifeng Miao, Yongming Qiu   +9 more
wiley   +1 more source

The Role of EVs in the Aging Hematopoietic System

Aging Cell, Volume 25, Issue 10, October 2026.
Extracellular vesicles from aged bone marrow carry pro‐inflammatory cargo that drives blood stem cell decline, while youthful vesicles restore or maintain stem cell function. Circulating vesicles therefore represent both a readout of hematopoietic aging and a potential therapeutic route.
Esra G. Kosebent, Nathalie Havranek, Karoline Kollmann, Kristina Kirschner, Eszter Doma, Kavya Gupta   +5 more
wiley   +1 more source

Expression of the Human Telomerase Reverse Transcriptase in Pheochromocytoma and Neuroblastoma Tissues

Endocrine Journal, 2004
In an effort to clarify the role of telomerase in the pathogenesis of pheochromocytomas and neuroblastomas, and to test whether its component could serve as a marker of malignancy, we measured telomerase reverse transcriptase (TERT) mRNA in 31 human pheochromocytoma tissue samples (5 malignant, 23 benign and 3 suspected malignant) and 16 neuroblastoma ...
ISOBE, Kazumasa, YASHIRO, Toru, OMURA, Sakie, KANEKO, Michio, KANEKO, Setsuko, KAMMA, Hiroshi, TATSUNO, Ichiro, TAKEKOSHI, Kazuhiro, KAWAKAMI, Yasushi, NAKAI, Toshiaki   +9 more
openaire   +3 more sources

The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma

Immunology &Cell Biology, Volume 104, Issue 9, Page 881-895, October 2026.
(Left)The identification and elimination of tumour cells is enabled by the infiltration of functional innate and adaptive immune effectors into the TME, such as natural killer cells (NK cells) and cytotoxic T cells (CD8 T cells). Effective innate and adaptive immune responses facilitate immunological control of malignant outgrowth.
Sarah J. MacDonald, Matthew Drill, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira, Terence J. O'Brien, Rosalind L. Jeffree, Mastura Monif   +6 more
wiley   +1 more source

Eribulin mesylate targets human telomerase reverse transcriptase in ovarian cancer cells.

PLoS ONE, 2014
Treatment of advanced ovarian cancer involves platinum-based chemotherapy. However, chemoresistance is a major obstacle. Cancer stem cells (CSCs) are thought to be one of the causes of chemoresistance, but the underlying mechanism remains elusive ...
Satoko Yamaguchi, Yoshiko Maida, Mami Yasukawa, Tomoyasu Kato, Masayuki Yoshida, Kenkichi Masutomi   +5 more
doaj   +1 more source

The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase

BMC Cancer, 2002
Background The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catalytic subunit of telomerase.
Schulze Wolfgang, Schostak Martin, Straub Bernd, Krause Hans, Müller Markus, Burger Angelika M, Schrader Mark, Lauke Heidrun, Miller Kurt   +8 more
doaj   +1 more source

Quantification of hTERT Splice Variants in Melanoma by SYBR Green Real-time Polymerase Chain Reaction Indicates a Negative Regulatory Role for the β Deletion Variant

Neoplasia: An International Journal for Oncology Research, 2008
Telomerase activity is primarily determined by transcriptional regulation of the catalytic subunit, human telomerase reverse transcriptase (hTERT). Several mRNA splice variants for hTERT have been identified, but it is not clear if telomerase activity is
Lisa F. Lincz, Lisa-Maree Mudge, Fiona E. Scorgie, Jennette A. Sakoff, Christopher S. Hamilton, Michael Seldon   +5 more
doaj   +1 more source

Evaluation of telomerase expression in chronic periodontitis

Indian Journal of Dental Research, 2010
Background : Human telomerase is a multi subunit ribonucleoprotein enzyme concerned with telomeric lengthening and homeostasis in man. This enzyme has been found to be elevated in inflammatory conditions like rheumatoid arthritis and silica injury lung ...
Balaji T, Vettriselvi V, Paul Solomon, Rao Suresh   +3 more
doaj  

Is telomerase reactivation associated with the down-regulation of TGF β receptor-II expression in human breast cancer?

Cancer Cell International, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells.
Thomas Valene, Newbold Robert F, Elkak Abd E, Mokbel Kefah   +3 more
doaj   +1 more source