Results 71 to 80 of about 24,740 (216)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Immunoexpression of human telomerase reverse transcriptase in fibroepithelial tumors of the breast

JKKI (Jurnal Kedokteran dan Kesehatan Indonesia), 2023
Background: Phyllodes tumors and fibroadenomas are groups of fibroepithelial tumors in the breast that have different therapeutic approaches due to their rate of progression.
Fairuz Fairuz, Humaryanto Humaryanto
doaj   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Increased telomerase activity and human telomerase reverse transcriptase mRNA expression in the endometrium of patients with endometriosis [PDF]

, 2007
BACKGROUND: Endometriosis is considered a frequent, benign disease with the ability to undergo neoplastic processes. The aim of this study was to evaluate the limitless replication potential of the endometrium in patients with endometriosis by examining ...
조시현, 정다정, 이병석, 조동제, 김청미, 박기현   +5 more
core   +1 more source

Identification of human TERT elements necessary for telomerase recruitment to telomeres

eLife, 2014
Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch,
Jens C Schmidt, Andrew B Dalby, Thomas R Cech   +2 more
doaj   +1 more source

The non-reverse transcriptase activity of the human telomerase reverse transcriptase promotes tumor progression (Review)

International Journal of Oncology, 2014
In human cancer, high expression of telomerase is correlated with tumor aggressiveness and metastatic potential. Human telomerase reverse transcriptase (hTERT), which regulates telomere length, can promote tumor development. Most research on hTERT has been focused on its crucial function of telomere maintenance.
Yong, Qin, Hong, Guo, Bo, Tang, Shi-Ming, Yang   +3 more
openaire   +3 more sources

RNA Binding Domain of Telomerase Reverse Transcriptase

, 2001
Telomerase is a ribonucleoprotein reverse transcriptase that extends the ends of chromosomes. The two telomerase subunits essential for catalysis in vitro are the telomerase reverse transcriptase (TERT) and the telomerase RNA.
Lai, Cary, Collins, Kathleen, Mitchell, James R   +2 more
core   +1 more source

Endogenous Telomerase Reverse Transcriptase N-Terminal Tagging Affects Human Telomerase Function at Telomeres In Vivo [PDF]

, 2017
Telomerase action at telomeres is essential for the immortal phenotype of stem cells and the aberrant proliferative potential of cancer cells. Insufficient telomere maintenance can cause stem cell and tissue failure syndromes, while increased telomerase ...
Gill, Manraj S, Zhang, Xiaozhu, Wu, Robert A, Collins, Kathleen, Chiba, Kunitoshi, Vogan, Jacob M, Hockemeyer, Dirk   +6 more
core   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Expression of the Human Telomerase Reverse Transcriptase in Pheochromocytoma and Neuroblastoma Tissues

Endocrine Journal, 2004
In an effort to clarify the role of telomerase in the pathogenesis of pheochromocytomas and neuroblastomas, and to test whether its component could serve as a marker of malignancy, we measured telomerase reverse transcriptase (TERT) mRNA in 31 human pheochromocytoma tissue samples (5 malignant, 23 benign and 3 suspected malignant) and 16 neuroblastoma ...
ISOBE, Kazumasa, YASHIRO, Toru, OMURA, Sakie, KANEKO, Michio, KANEKO, Setsuko, KAMMA, Hiroshi, TATSUNO, Ichiro, TAKEKOSHI, Kazuhiro, KAWAKAMI, Yasushi, NAKAI, Toshiaki   +9 more
openaire   +3 more sources