Results 91 to 100 of about 23,184 (172)

In Vitro Expansion of Human Hepatocytes is Restricted by Telomere-Dependent Replicative Aging

Cell Transplantation, 2003
Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies.
Henning Wege, Michael S. Chui, Hai T. Le, Stephen C. Strom, Mark A. Zern   +4 more
doaj   +1 more source

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia. [PDF]

Genes (Basel), 2021
Yik MY, Azlan A, Rajasegaran Y, Rosli A, Yusoff NM, Moses EJ.   +5 more
europepmc   +1 more source

Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene. [PDF]

Proc Natl Acad Sci U S A, 2021
Xu T, Cheng, Zhao Y, Zhang J, Zhu X, Zhang F, Chen G, Wang Y, Yan X, Robertson GP, Gaddameedhi S, Lazarus P, Wang S, Zhu J.   +13 more
europepmc   +1 more source

The Regulation of ROS- and BECN1-Mediated Autophagy by Human Telomerase Reverse Transcriptase in Glioblastoma. [PDF]

Oxid Med Cell Longev, 2021
Ding X, Nie Z, She Z, Bai X, Yang Q, Wang F, Wang F, Geng X.   +7 more
europepmc   +1 more source

In silico Analysis of Human Telomerase Reverse Transcriptase (hTERT ) Gene: Identification of a Distant Homolog of Melanoma Antigen Family Gene (MAGE)

Cancer Informatics, 2009
Melanoma antigen family (MAGE) genes are widely expressed in various tumor types but silent in normal cells except germ-line cells lacking human leukocyte antigen (HLA) expression.
Ruhul Amin, Jesmin, Hasan Jamil, M. Anwar Hossain   +3 more
doaj  

Enhanced long-term survival, but no increase in replicative capacity, following retroviral transduction of human cord blood CD34+ cells with human telomerase reverse transcriptase

Haematologica, 2004
Overexpression of telomerase reverse transcriptase (hTERT) can immortalize some primary human mesenchymal cells. We investigated whether retrovirally-mediated expression of hTERT in CD34+ umbilical cord blood (UCB) cells can extend the replicative ...
NJ Elwood, XR Jiang, CP Chiu, JS Lebkowski, CA Smith   +4 more
doaj  

Human telomerase reverse transcriptase promotes the epithelial to mesenchymal transition in lung cancer cells by enhancing c-MET upregulation. [PDF]

Heliyon, 2022
Prasad RR, Prasad RR, Mishra DK, Kumar M, Yadava PK.   +4 more
europepmc   +1 more source

Knockdown of tankyrase 1 inhibits the progression of gastric adenocarcinoma via regulating human telomerase reverse transcriptase and telomeric repeat binding factor 1. [PDF]

J Gastrointest Oncol, 2022
Liu W, Zhu JJ, Liu YY, Tang NN, Wang Y, Jiang B, Wang LL, Wang YX, Xie MP, Wang XY.   +9 more
europepmc   +1 more source

Retraction Statement: Exosomal miR-1255b-5p targets human telomerase reverse transcriptase in colorectal cancer cells to suppress epithelial-to-mesenchymal transition. [PDF]

Mol Oncol, 2023
europepmc   +1 more source

SPT6 recruits SND1 to co-activate human telomerase reverse transcriptase to promote colon cancer progression. [PDF]

Mol Oncol, 2021
Diao C, Guo P, Yang W, Sun Y, Liao Y, Yan Y, Zhao A, Cai X, Hao J, Hu S, Yu W, Chen M, Wang R, Li W, Zuo Y, Pan J, Hua C, Lu X, Fan W, Zheng Z, Deng W, Luo G, Guo W.   +22 more
europepmc   +1 more source