Results 91 to 100 of about 24,740 (216)

Effective siRNA targets screening for human telomerase reverse transcriptase

World Journal of Gastroenterology, 2005
To study the inhibitory effects of siRNAs targeting different hTERT sequences and to screen the effective siRNA sequence.Five double-stranded siRNAs targeting coding and non-coding regions of hTERT gene were designed and synthesized by T7 transcription system in vitro. siRNA4 sequence was screened by full length gene targeting technique and the rest of
Yun, Xia, Ru-Xian, Lin, Su-Jun, Zheng, Ying, Yang, Xiao-Chen, Bo, Dao-Yin, Zhu, Sheng-Qi, Wang   +6 more
openaire   +2 more sources

Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues [PDF]

Oncogene, 2000
Although telomerase activity in hepatocellular carcinoma (HCC) increases in accordance with degree of histological undifferentiation, it is unknown whether the level of telomerase activity in HCC reflects of the degree of activity in individual cells or the frequency of telomerase-positive HCC cells.
G.Kajiyama., Y.Kawakami, M.Kitamoto, T.Nakanishi, W.Yasui, E.Tahara, J.Nakayama, F.Ishikawa, H.Tahara, T.Ide   +9 more
openaire   +2 more sources

Expression of hTERT mRNA in Anip973 and Anip973/NVB Cell Detected by Quantitative Real-time PCR

Chinese Journal of Lung Cancer, 2010
Background and objective Human telomerase reverse transcriptase is the catalytic subunit of telomerase, and its activity is correlated with cell’s sensitivity to chemotherapy.
Jingjing LIU, Shuying GUO, Gongyan CHEN
doaj  

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase

, 2000
Replicative senescence of T cells is correlated with erosion of telomere ends. Telomerase plays a key role in maintaining telomere length. Therefore, it is thought that telomerase regulates the life span of T cells.
Ruizendaal, J. J., Snijders, P. J., Spits, H., Walboomers, J. M., Hooijberg, E., Kueter, E. W.   +5 more
core   +1 more source

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, Volume 6, Issue 6, June 2026.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Ectopic expression of telomerase enhances osteopontin and osteocalcin expression during osteogenic differentiation of human mesenchymal stem cells from elder donors

Journal of Stem Cells and Regenerative Medicine, 2009
Age related bone loss is one of the most prevalent diseases in the elder population. The osteoblasts are the effectors cells of bone formation and regeneration.
Machado CB, Correa CR, Medrado GC, Leite MF, Goes AM   +4 more
doaj  

Relationship between hTERT levels and oxidative stress in epilepsy patients

Epilepsia Open, Volume 11, Issue 3, Page 752-763, June 2026.
Abstract Objective Human telomerase reverse transcriptase (hTERT) is a key determinant of telomere maintenance and cellular aging. Oxidative stress plays a role in neurodegenerative processes by causing cellular damage through increased reactive oxygen species.
Muhammed Mehdi Üremiş, Deniz Tuncel Berktaş, Nuray Üremiş, Fatma İnanç Tolun   +3 more
wiley   +1 more source

Functional identification and mapping of a gene that represses telomerase hTERT transcription in prostate cancer cells

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomerase is present in over 90% of tumour tissues and immortalized cells and is tightly regulated in most normal somatic cells.
Hasan, Rana
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