Results 91 to 100 of about 40,478 (236)

Improvement of erectile dysfunction using endothelial progenitor cells from fetal cerebral vasculature in the cavernous nerve injury of rats

Basic and Clinical Andrology, 2022
Résumé Contexte En raison de la différenciation limitée de l’endothélium à partir de cellules souches mésenchymateuses, il a été fortement recommandé d’utiliser des cellules progénitrices endothéliales pour la régénération de l’endothélium endommagé des ...
Jae Heon Kim, Sang Hong Bak, Hee Jo Yang, Seung Whan Doo, Do Kyung Kim, Won Jae Yang, Seung U. Kim, Hong J. Lee, Yun Seob Song   +8 more
doaj   +1 more source

Cytogenetic features of human trophoblast cell lines SWAN-71 and 3A-subE [PDF]

, 2017
Immortalization of primary cells with telomerase is thought to maintain normal phenotypic properties and avoid chromosomal abnormalities and other cancer-associated changes that occur following simian virus 40 tumor antigen (SV40 Tag) induced ...
Chakraborty, Sujata, Drendel, Holli M., Lee, Men-Jean, Mor, Gil, Reiter, Jill L., Schellinger, Megan M.   +5 more
core   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Recent progress in human telomerase structure and its therapeutic targeting

Frontiers in Molecular Biosciences
Most cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori, Abdulrahman Awad, Sarah Dhaiban, Mohammed Turki Alduhoori, Humayun Sharif, Abdulrahim Sajini   +5 more
doaj   +1 more source

Telomerase reverse transcriptase mediated immortalization of human bone marrow stromal cells

Brazilian Archives of Biology and Technology, 2014
Primary human bone marrow stromal cells (hMSCs) were transfected with human telomerase reverse transcriptase (hTERT) gene with lipofection method.
Yong Teng, YunYu Hu, Xu Sheng Li, Zhen Wang, Rui Wang   +4 more
doaj   +1 more source

The correlation between telomerase activity and BaX/BcL-2 ratio in valproic acid-treated MCF-7 breast cancer cell line [PDF]

, 2015
Objective(s): Valproic acid (VPA), a drug used in the treatment of neurological disorders, has been shown to have cytotoxic effects on cancer cells through different mechanisms.
Asadi, J., Gharaei, R., Vafaiyan, Z.
core   +2 more sources

Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]

, 2017
A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro, Masui, Kenta, Mischel, Paul S, Sawada, Tatsuo, Shibata, Noriyuki   +4 more
core   +2 more sources

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Liquid biopsy in genitourinary oncology: Current clinical applications and future prospects across prostate, bladder, and renal cancers

UroPrecision, EarlyView.
Abstract Liquid biopsy has emerged as a transformative approach in oncology, providing minimally invasive access to tumor‐derived biomarkers with applications across diagnosis, prognosis, therapeutic guidance, and disease monitoring. This literature review synthesizes evidence from 125 studies evaluating circulating tumor DNA, circulating tumor cells ...
Kirolos Eskandar
wiley   +1 more source

Expression of hTERT mRNA in Anip973 and Anip973/NVB Cell Detected by Quantitative Real-time PCR

Chinese Journal of Lung Cancer, 2010
Background and objective Human telomerase reverse transcriptase is the catalytic subunit of telomerase, and its activity is correlated with cell’s sensitivity to chemotherapy.
Jingjing LIU, Shuying GUO, Gongyan CHEN
doaj