Results 111 to 120 of about 24,740 (216)

Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos

Cell Proliferation, Volume 59, Issue 6, June 2026.
Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang, Yan Zhang, Laijin Wu, Hongshuang Xie, Guang Yang, Yiwei Zhang, Cheng Huang, Shanyi Chou, Xuehan Li, Zhonghua Liu, Jiaqiang Wang   +10 more
wiley   +1 more source

Genistein-Induced Apoptosis Affects Human Telomerase Reverse Transcriptase Activity in Acute Promyelocytic Leukemia

, 2020
BACKGROUND/AIMS The purpose of this study was to research the effects of genistein on telomerase activity and apoptosis in an acute promyelocytic leukemia cell line (HL-60).
Süslüer, Sunde, Gündüz, Cumhur, Okçanoğlu, Tuğçe Balcı, Avcı, Çığır Biray, Kayabaşı, Çağla, Saydam, Guray   +5 more
core   +2 more sources

Evaluation of telomerase expression in chronic periodontitis

Indian Journal of Dental Research, 2010
Background : Human telomerase is a multi subunit ribonucleoprotein enzyme concerned with telomeric lengthening and homeostasis in man. This enzyme has been found to be elevated in inflammatory conditions like rheumatoid arthritis and silica injury lung ...
Balaji T, Vettriselvi V, Paul Solomon, Rao Suresh   +3 more
doaj  

Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management

Neurosignals, 2014
Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity and
Fanny C.F. Ip, Yu Pong Ng, H.J. An, Ying Dai, Hai Hong Pang, Yue Qing Hu, Allison C. Chin, Calvin B. Harley, Yung Hou Wong, Nancy Y. Ip   +9 more
doaj   +1 more source

Association of human telomerase reverse transcriptase promoter mutation with unfavorable prognosis in glioma: A systematic review and meta-analysis. [PDF]

J Res Med Sci, 2023
Hua R, Li Q, Gao H, Wang B, He C, Wang Y, Zhang S, Gao L, Shang H, Wang W, Xu J.   +10 more
europepmc   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, Volume 88, Issue 7, Page 1315-1323, June 2026.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Telomerase Reverse Transcriptase Fragments And Uses Thereof [PDF]

, 2007
The Invention Provides Compositions Comprising Fragments Of Human Telomerase Reverse Transcriptase (Htert) Which Can Lead To Telomere Dysfunction In A Cell And Reduction Of Growth And Tumorigenicity In Cancer Cells.

core  

Telomerase and Telomeres in Endometrial Cancer

Frontiers in Oncology, 2019
Telomeres at the termini of human chromosomes are shortened with each round of cell division due to the “end replication problem” as well as oxidative stress.
Rafah A. A. Alnafakh, Rafah A. A. Alnafakh, Meera Adishesh, Meera Adishesh, Lucy Button, Lucy Button, Gabriele Saretzki, Dharani K. Hapangama, Dharani K. Hapangama   +8 more
doaj   +1 more source

The aging paradox of Cushing's syndrome: Stress without clear senescence?

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira, Alexandro Guterres   +1 more
wiley   +1 more source

Human adenovirus DNA polymerase is evolutionarily and functionally associated with human telomerase reverse transcriptase based on in silico molecular characterization that implicate abacavir and zidovudine. [PDF]

Front Bioinform, 2023
Fatoki TH.
europepmc   +1 more source