Results 131 to 140 of about 23,184 (172)

Changes in telomerase activity due to alternative splicing of human telomerase reverse transcriptase in colorectal cancer. [PDF]

Oncol Lett, 2017
Jeung HC, Rha SY, Shin SJ, Ahn JB, Park KH, Kim TS, Kim JJ, Roh JK, Chung HC.   +8 more
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RIF1 promotes human epithelial ovarian cancer growth and progression via activating human telomerase reverse transcriptase expression. [PDF]

J Exp Clin Cancer Res, 2018
Liu YB, Mei Y, Long J, Zhang Y, Hu DL, Zhou HH.   +5 more
europepmc   +1 more source

Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component

Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component
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Activation of telomerase and expression of human telomerase reverse transcriptase in coronary atherosclerosis

Cardiovascular Pathology, 2005
Considerable research on telomerase on human neoplastic and normal long-lived proliferative tissues has emerged. We explored the expression of telomerase in atherosclerotic human epicardial coronary arteries.Forty discrete human coronary arterial segments obtained from 19 heart transplant recipients were classified into nonatherosclerotic and ...
Mu-Zon Wu, Shoei-Shen Wang
exaly   +3 more sources

Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas

Human Pathology, 2001
The aim of this study was to evaluate the usefulness of determination of telomerase activity and expression of human telomerase RNA component (hTERC) and human telomerase reverse transcriptase (hTERT) for the diagnosis of lung carcinomas. The tissues studied consisted of 115 carcinomas and adjacent nonneoplastic lung, which were removed surgically ...
Nariyoshi Shinomiya, Víctor J Ferrans, Yuichi Ozeki   +2 more
exaly   +3 more sources

Expression of Human Telomerase Reverse Transcriptase in Lymphangioleiomyomatosis

American Journal of Respiratory and Critical Care Medicine, 2002
Abstract Telomerase synthesizes nucleotide hexameric repeats (telomeres) at the ends of chromosomes, replacing base sequences that are lost from these sites during each mitotic cycle and protecting these ends against the action of exonucleases and ligases. Therefore, telomerase is essential for maintaining cellular replication.
Fumiyuki, Kumaki, Kazuyo, Takeda, Zu-Xi, Yu, Joel, Moss, Victor J, Ferrans   +4 more
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The significance of human telomerase reverse transcriptase (hTERT) in cancer

European Journal of Surgical Oncology (EJSO), 2001
Since the discovery of the enzyme telomerase in humans, it has become apparent that it is the most general of tumour markers known, and enormously significant in its potential for diagnostic, prognostic and therapeutic applications. Extensive work has identified three core components of the enzyme, of which the catalytic subunit hTERT (human telomerase
K L, Kirkpatrick, K, Mokbel
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Butylidenephthalide Suppresses Human Telomerase Reverse Transcriptase (TERT) in Human Glioblastomas

Annals of Surgical Oncology, 2011
Telomerase is widely expressed in most human cancers, but is almost undetectable in normal somatic cells and is therefore a potential drug target. Using the human telomerase promoter platform, the naturally occurring compound butylidenephthalide (BP) was selected for subsequent investigation of antitumor activity in vitro and in vivo.We treated human ...
Po-Cheng, Lin, Shinn-Zong, Lin, Yi-Lin, Chen, Jeng-Shou, Chang, Li-Ing, Ho, Po-Yen, Liu, Li-Fu, Chang, Yeu-Chern, Harn, Shee-Ping, Chen, Li-Yi, Sun, Pi-Chun, Huang, Jung-Ting, Chein, Chang-Hai, Tsai, Chii-Wen, Chou, Horng-Jyh, Harn, Tzyy-Wen, Chiou   +15 more
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Immortalization of human osteoblasts by transferring human telomerase reverse transcriptase gene

Biochemical and Biophysical Research Communications, 2004
In the current study, in order to establish an immortalized osteoblast cell line, human mesenchymal stem cells (hMSCs) had been inducted into osteoblasts directionally by an osteo-inductive conditioned medium, then the osteoblasts were steadily transduced by a retroviral vector containing human telomerase reverse transcriptase (hTERT) gene.
Yin, Xiaoxue, Chen, Zhongqiang, Guo, Zhaoqing, Dang, Gengting, Ma, Qingjun, Wang, Shenwu   +5 more
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Effects of smoking on human telomerase reverse transcriptase expression in the skin

International Journal of Dermatology, 2014
AbstractBackgroundTelomeres are DNA–protein complexes that cap chromosomal ends, promoting chromosome stability. Telomerase is a ribonucleoprotein complex with a direct telomere protective function. Telomere shortening represents lifetime exposure to oxidative stress and is negatively correlated with age, smoking, and mortality.
Ranya A, Lotfi, Khaled M, El Zawahry, Zeinab A, Kamar, Zamzam, Hashem   +3 more
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