Biopharmaceuticals for Cancer Treatment: An Update
Cancer Medicine, Volume 15, Issue 4, April 2026.ABSTRACT Cancer is one of the most debilitating diseases, causing profound physical and psychological impacts on patients. The global number of cancer patients has been steadily rising over the last few decades. The development of effective cancer therapies remains the primary focus in life science research, requiring a precise understanding of ...
Anupom Deb Nath +6 more
wiley +1 more source
Human Telomerase Reverse Transcriptase as a Therapeutic Target of Dihydroartemisinin for Esophageal Squamous Cancer. [PDF]
Front Pharmacol, 2021 Li Q +11 more
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao +8 more
wiley +1 more source
Implications of risk conferred by 5p15.33 loci genetic variants; human telomerase reverse transcriptase rs2736098 and rs2736100 in predisposition of bladder cancer. [PDF]
Rep Pract Oncol Radiother, 2022 Anwar I +10 more
europepmc +1 more source
Preoperative Detection of Dual TERT Promoter Mutations in Thyroid Cancer: A Case Series
Diagnostic Cytopathology, Volume 54, Issue 4, Page E108-E112, April 2026.ABSTRACT Telomerase reverse transcriptase promoter (TERTp) mutations are associated with aggressive thyroid cancer and are most frequently found in anaplastic and poorly differentiated thyroid cancer. Pre‐operative thyroid nodule molecular testing can detect TERTp, denoting a high risk of malignancy and possible aggressive clinical features such as ...
Amir Harari +7 more
wiley +1 more source
Influence of Human Telomerase Reverse Transcriptase Mutation on the Aggressiveness and Recurrence in Meningiomas. [PDF]
Cureus, 2021 Sahin B +8 more
europepmc +1 more source
Multiomics Research Strategies in Cancer: A Growing and Innovative Field
MedComm, Volume 7, Issue 4, April 2026.This review highlights multiomics strategies in cancer research, focusing on integration methods from genomics to microbiomics. Using colorectal cancer as a key example, it discusses biomarker discovery, data integration via deep learning, and the roles of single‐cell and spatial omics.
Zhenhua Du +8 more
wiley +1 more source
In Vitro Expansion of Human Hepatocytes is Restricted by Telomere-Dependent Replicative Aging
Cell Transplantation, 2003 Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies.
Henning Wege +4 more
doaj +1 more source
Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia. [PDF]
Genes (Basel), 2021 Yik MY +5 more
europepmc +1 more source
Phytotherapy Research, Volume 40, Issue 4, Page 1970-2002, April 2026.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source